Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

A new gereration of anticancer pronucleotides

2011/01/B/NZ4/04936

Keywords:

nucleotides nucleotide analogues anticancer drugs pronucleotides prodrugs

Descriptors:

  • NZ4_17:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jacek Stawiński 

Number of co-investigators in the project: 12

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 793 000 PLN

Project start date (Y-m-d): 2011-12-16

Project end date (Y-m-d): 2015-12-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Lampa UV z filtrami i obudowa (1 500 PLN)
  2. Pompa próżniowa membranowa z kontrolerem próżni (3 szt.) (30 000 PLN)
  3. pH-metr przenosny (2 000 PLN)
  4. Kontroler prozni (3 500 PLN)
  5. Laboratoryjne termostatowane płaszcze grzejne 1000 ml (2 szt.) (3 500 PLN)
  6. Minichiller Huber.
  7. Pipety automatyczne (12 szt.) (7 000 PLN)
  8. Kolumny HPLC-guard (6 szt.) (4 000 PLN)
  9. Mieszadła magnetyczne z grzaniem (2 szt.) (4 000 PLN)
  10. Reference Menager - program.
  11. Kolumny HPLC (9 szt.) (12 000 PLN)
  12. Licencja ChemOffice.
  13. Termomikser (4 500 PLN)
  14. Wagi analityczne (2 szt.) (3 000 PLN)
  15. Zestaw komputerowy (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (3)
  1. New 3'-O-aromatic acyl-5-fluoro-2'-deoxyuridine derivatives as potential anticancer agents
    Authors:
    Agnieszka Szymańska-Michalaka, Dariusz Wawrzyniak, Grzegorz Framski,Marta Kujda, Paulina Zgoła, Jacek Stawiński, Jan Barciszewski, Jerzy Boryski, and Adam Kraszewski
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2016, tom: 115, strony: 41-52), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2016.03.010 - link to the publication
  2. Searching for anti-glioma activity. Ribonucleoside analogues with modifications in nucleobase and sugar moieties.
    Authors:
    Grzegorz Framski, Dariusz Wawrzyniak, Zofia Jahnz-Wechmann, Agnieszka Szymanska-Michalak, Adam Kraszewski, Jan Barciszewski, Jerzy Boryski, and Jacek Stawinski
    Academic press:
    Acta Biochimica Polonica (rok: 2016, ), Wydawca: ABP
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  3. Recent Advances in H-Phosphonate Chemistry. Part 2. Synthesis of C-Phosphonate Derivatives
    Authors:
    Michal Sobkowski, Adam Kraszewski, and Jacek Stawinski
    Academic press:
    Topics in Current Chemistry (rok: 2015, tom: 361, strony: 179-216), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/128_2014_563 - link to the publication
  4. Recent Advances inH-Phosphonate Chemistry. Part 1. H-Phosphonate Esters: Synthesis and Basic Reactions
    Authors:
    Michal Sobkowski, Adam Kraszewski, and Jacek Stawinski
    Academic press:
    Topics in Current Chemistry (rok: 2015, tom: 361, strony: 137-178), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/128_2014_562 - link to the publication
  1. NEW APPLICATIONS OF 6-ALKYL-2,3-DIHYDROFURANO[2,3-d]PYRIMIDIN-2(1H)-ONE AND 6-ALKYL-2,3-DIHYDROPYRROLO[2,3-d]PYRIMIDIN-2(3H,7H)-ONE NUCLEOSIDES: ANTICANCER PROPERTIES
    Authors:
    Grzegorz Framski*, Dariusz Wawrzyniak*, Zofia Jahnz-Wechmann, Agnieszka Szymańska-Michalak, Jan Barciszewski, Jerzy Boryski, Adam Kraszewski and Jacek Stawiński
    Conference:
    XXI International Round Table Conference (rok: 2014, ), Wydawca: IRT
    Data:
    konferencja Poznan, 24-28 September
    Status:
    Published
  2. CELL CYCLE ARREST, APOPTOSIS AND ANTI-PROLIFERATIVE ACTIVITY OF NEW 3'-O-ACYL-2'-DEOXY-5-FLUOROURIDINE DERIVATIVES
    Authors:
    Agnieszka Szymańska-Michalak*, Dariusz Wawrzyniak*, Grzegorz Framski, Jan Barciszewski, Jerzy Boryski, Adam Kraszewski and Jacek Stawiński
    Conference:
    XXI International Round Table Conference (rok: 2014, ), Wydawca: IRT
    Data:
    konferencja Poznan, 24-28 September
    Status:
    Published
  3. SYNTHESIS AND ANTI-PROLIFERATIVE ACTIVITY OF KINETIN RIBOSIDE DERIVATIVES AGAINST ADHERENT TUMOR CELL LINES. INSIGHTS INTO THE MECHANISM OF ACTION
    Authors:
    Dariusz Wawrzyniak*, Agnieszka Szymańska-Michalak, Grzegorz Framski, Eliza Wyszko, Jerzy Boryski, Adam Kraszewski, Jacek Stawiński and Jan Barciszewski
    Conference:
    XXI International Round Table Conference (rok: 2014, ), Wydawca: IRT
    Data:
    konferencja Poznan, 24-28 September
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy