Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Interactions of human cystatin C with antibodies as an effective method of fighting Icelandic type hereditary cerebral hemorrhage with amyloidosis.

2011/01/N/ST5/05642

Keywords:

human cystatin C dimerization antibodies epitope hereditary cerebral amyloid angiopathy

Descriptors:

  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Gdański, Wydział Chemii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Izabela Behrendt 

Number of co-investigators in the project: 4

Call: PRELUDIUM 1 - announced on 2011-03-15

Amount awarded: 296 200 PLN

Project start date (Y-m-d): 2011-12-19

Project end date (Y-m-d): 2015-12-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do elektroforezy horyzontalnej agarozowej (2 000 PLN)
  2. Aparat do elektroforezy poliakrylamidowej w warunkach denaturujących (SDS-PAGE) (3 000 PLN)
  3. Komputer (3 500 PLN)
  4. Zestaw do testu ELISA (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  1. Application of amide hydrogen/deuterium exchange mass spectrometry for epitope mapping in human cystatin C
    Authors:
    Martyna Prądzińska, Izabela Behrendt, Juan Astorga-Wells, Aleksandr Manoilov, Roman A. Zubarev, Aleksandra S. Kołodziejczyk, Sylwia Rodziewicz-Motowidło, Paulina Czaplewska
    Academic press:
    Amino Acids (rok: 2016, tom: brak danych, strony: ), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  2. Epitope location for two monoclonal antibodies against human cystatin C, representing opposite aggregation inhibitory properties
    Authors:
    Izabela Behrendt, Martyna Prądzińska, Marta Spodzieja, Aleksandra S. Kołodziejczyk, Sylwia Rodziewicz-Motowidło, Aneta Szymańska, Paulina Czaplewska
    Academic press:
    Amino Acids (rok: 2016, tom: 48, strony: 1717–1729), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00726-016-2242-z - link to the publication

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