Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Chemical synthesis of 1-O-acyl-2-O-methyl-3-O-phosphodiester and 1-O-acyl-2-O-methyl-3-O-phosphorothioate analogs of selected lysophospholipids (lysophosphatidylcholine, lysophasphitydylinositol, lysophosphatidylethanolamine) and preliminary studies of their biological activity

2011/01/B/ST5/06383

Keywords:

synthesis of lysophospholipid analogs phosphodiester and phosphorothioate derivatives lysophosphatidylcholine lysophosphatidylinositol lysophosphatidylethanolamine membrane receptors

Descriptors:

  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Andrzej Okruszek 

Number of co-investigators in the project: 8

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 363 800 PLN

Project start date (Y-m-d): 2011-12-01

Project end date (Y-m-d): 2015-11-30

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zamrażarka głębokiego chłodzenia (-70oC) (31 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  1. Novel bioactive glycerol-based lysophospholipids: New data - New insight into their function
    Authors:
    Anna Grzelczyk, Edyta Gendaszewska-Darmach
    Academic press:
    Biochimie (rok: 2013, tom: 95, strony: 667-679), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.0009 - link to the publication
  2. Sulfur- and Acyl Chain-Dependent Influence of 2-Methoxy-Lysophosphatidylcholine Analogues on β Pancreatic Cells
    Authors:
    Anna Drzazga, Anna Ciesielska and Edyta Gendaszewska-Darmach
    Academic press:
    Current Topics in Medicinal Chemistry (rok: 2015, tom: 15, strony: 2395-3405), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/1568026615666150619141239 - link to the publication
  3. The chemical synthesis and cytotoxicity of new sulfur analogues of 2-methoxy-lysophosphatidylcholine
    Authors:
    Przemysław Rytczak, Anna Drzazga, Edyta Gendaszewska-Darmach, Andrzej Okruszek
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2013, tom: 23, strony: 6794-6798), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.020 - link to the publication
  4. Cykliczne kwasy fosfatydowe i ich analogi - mediatory lipidowe o unikalnych właściwościach
    Authors:
    Anna Grzelczyk, Maria Koziołkiewicz
    Academic press:
    Postępy Biochemii (rok: 2012, tom: 58(3), strony: 327-343), Wydawca: Polskie towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  5. The chemical synthesis of metabolically stabilized 2-OMe-LPA analogues and preliminary studies of their inhibitory activity toward autotaxin
    Authors:
    Edyta Gendaszewska-Darmach, Edyta Laska, Przemysław Rytczak, Andrzej Okruszek
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2012, tom: 22, strony: 2608-2700), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2012.03.008 - link to the publication

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