Identification of brain specific non-coding microRNAs in mice: 1 - regulating a synaptic plasticity in learning&memory and 2 - controlling an Insulin-mTOR signalling pathway in neurons responsible for development of obesity syndrome

2011/01/D/NZ4/03744

Keywords

Descriptors

  • NZ4_9: Neurobiologia systemowa
  • NZ3_5: Neurobiologia molekularna
  • NZ4_10: Neuroobrazowanie

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Witold Adam Konopka

Number of co-investigators in the project: 3

Call

SONATA 1 – announced on 2011-03-15

Amount awarded
1 000 000 PLN
Project start date
2012-06-29
Project end date
2017-06-28
Project duration
60 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Maszyna PCR. Cost: 20 000 PLN
  2. Przystawka do maszyny PCR.
  3. Termomixer.
  4. Zestaw do elektroforezy DNA. Cost: 16 000 PLN
  5. Zestaw do elektroforezy i transferu białek.
  6. Zestaw komputerowy (2 pcs). Cost: 15 000 PLN

Information in the final report

Publication in academic press/journals (2)

  1. Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons.

    Authors:
    Kiryk A, Sowodniok K, Kreiner G, Rodriguez-Parkitna J, Sönmez A, Górkiewicz T, Bierhoff H, Wawrzyniak M, Janusz AK, Liss B, Konopka W, Schütz G, Kaczmarek L, Parlato R.
    Academic press:
    Front Cell Neurosci (year: 2013, volume: 7, pages: 207), Publisher: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fncel.2013.00207 – link to the publication
  2. Hypothalamic miR-103 protects from hyperphagic obesity in mice

    Authors:
    Vinnikov IA, Hajdukiewicz K, Reymann J, Beneke J, Czajkowski R, Roth LC, Novak M, Roller A, Dörner N, Starkuviene V, Theis FJ, Erfle H, Schütz G, Grinevich V, Konopka W
    Academic press:
    J Neurosci (year: 2014, volume: 34(32), pages: 10659-74), Publisher: Society for Neuroscience
    Status:
    Published
    DOI:
    10.1523/JNEUROSCI.4251-13.2014 – link to the publication

Book publications / chapters in book publications (1)

  1. Continuous Delivery of Oligonucleotides into the Brain

    Authors:
    Vinnikov IA, Domanskyi A, Konopka W.
    Book:
    MicroRNA Technologies (Springer Protocols) (year: 2017, volume: 128, pages: 89-117), Publisher: Springer New York
    Status:
    Published

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