Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Midkine, a multifunctional cytokine, in inflammatory bowel diseases (Crohn's disease and ulcerative colitis) - role in pathogenesis and repair, diagnostic and therapeutic potential

2011/01/D/NZ5/02835

Keywords:

midkine inflammatory bowel disease Crohn's disease ulcerative colitis biomarker

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Lekarski

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Krzystek-Korpacka 

Number of co-investigators in the project: 8

Call: SONATA 1 - announced on 2011-03-15

Amount awarded: 584 460 PLN

Project start date (Y-m-d): 2011-12-06

Project end date (Y-m-d): 2014-12-05

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Nanodrop 2000 (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance
    Authors:
    Malgorzata Krzystek-Korpacka, Dorota Diakowska, Bartosz Kapturkiewicz, Marek Bębenek, Andrzej Gamian
    Academic press:
    Cancer Letters (rok: 2013, tom: 337, strony: 107–114), Wydawca: Elsevier Ireland Ltd.
    Status:
    Published
    DOI:
    10.1016/j.canlet.2013.05.033 - link to the publication
  2. Elevated systemic interleukin‑7 in patients with colorectal cancer and individuals at high risk of cancer: association with lymph node involvement and tumor location in the right colon
    Authors:
    Malgorzata Krzystek-Korpacka, Marek Zawadzki, Katarzyna Neubauer, Iwona Bednarz-Misa, , Sabina Gorska, Jerzy Wisniewski, Wojciech Witkiewicz, Andrzej Gamian
    Academic press:
    Cancer Immunology, Immunotherapy (rok: 2016, tom: brak, strony: brak), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00262-016-1933-3 - link to the publication
  3. Expression stability of common house-keeping genes is differently affected by bowel inflammation and cancer. Implications for finding suitable normalizers for inflammatory bowel disease (IBD) studies
    Authors:
    Krzystek-Korpacka M, Diakowska D, Bania J, Gamian A
    Academic press:
    Inflammatory Bowel Diseases (rok: 2014, tom: 20, strony: 1147-56), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1097/MIB.0000000000000067 - link to the publication
  4. Midkine is up-regulated in both cancerous and inflamed bowel, reflecting lymph node metastasis in colorectal cancer and clinical activity of ulcerative colitis
    Authors:
    Krzystek-Korpacka Malgorzata, Gorska Sabina, Diakowska Dorota, Kapturkiewicz Bartosz, Podkowik Magdalena, Gamian Andrzej, Bednarz-Misa Iwona
    Academic press:
    Cytokine (rok: 2017, tom: 89, strony: 68-75), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cyto.2016.09.020 - link to the publication
  5. Serum availability affects expression of common house-keeping genes in colon adenocarcinoma cell lines – implications for quantitative real-time PCR studies
    Authors:
    Malgorzata Krzystek-Korpacka, Katarzyna Hotowy, Elzbieta Czapinska, Magdalena Podkowik, Jacek Bania, Andrzej Gamian, Iwona Bednarz-Misa
    Academic press:
    Cytotechnology (rok: 2016, tom: 68(6), strony: 2503-2517), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10616-016-9971-4 - link to the publication
  6. Circulating midkine in malignant and non-malignant colorectal diseases
    Authors:
    Krzystek-Korpacka M, Diakowska D, Neubauer K, Gamian A
    Academic press:
    Cytokine (rok: 2013, tom: 64, strony: 158–164), Wydawca: Elsevier Ltd
    Status:
    Published
    DOI:
    10.1016/j.cyto.2013.07.008 - link to the publication

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