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Dendrimers - potential drugs in chronic lymphocytic leukemia

2011/01/B/NZ5/01371

Keywords

Descriptors

  • NZ2_1: Genetyka molekularna
  • NZ1_1: Biologia molekularna
  • ST5_10: Nanomateriały: nanocząstki, nanorurki

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Maria Jolanta Bryszewska

Number of co-investigators in the project: 4

Call

OPUS 1 – announced on 2011-03-15

Amount awarded
298 600 PLN
Project start date
2011-12-01
Project end date
2014-11-30
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Termomikser Comfort 5355 z funkcją grzania i chłodzenia firmy Eppendorf. Cost: 10 000 PLN

Information in the final report

Publication in academic press/journals (5)

  1. The Influence of Glycodendrimer on Apoptosis in B-CLL Cells in vitro Defined by Microarrays

    Authors:
    Franiak-Pietryga I, Ziółkowska E, Ziemba B, Appelhans D, Maciejewski H, Voit B, Kaczmarek A, Robak T, Klajnert-Maculewicz B, Cebula-Obrzut B, Smolewski P, Borowiec M, Bryszewska M.
    Academic press:
    Anti-Cancer Agents in Medicinal Chemistry (year: 2016, volume: 16, pages: -), Publisher: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1871520616666160622092947 – link to the publication

  2. The Influence of Maltotriose-Modified Poly(propylene imine) Dendrimers on the Chronic Lymphocytic Leukemia Cells in Vitro: Dense Shell G4 PPI.

    Authors:
    Franiak-Pietryga I, Ziółkowska E, Ziemba B, Appelhans D, Voit B, Szewczyk M, Góra-Tybor J, Robak T, Klajnert B, Bryszewska M.
    Academic press:
    Molecular Pharmaceutics (year: 2013, volume: 10, pages: 2490-2501), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/mp400142p – link to the publication

  3. Dendrimer-based nanoparticles for potential personalized therapy in chronić lymphocytic leukemia: Targeting the BCR-signaling pathway.

    Authors:
    Franiak-Pietryga I, Maciejewski H, Ostrowska K, Appelhans D, Voit B, Misiewicz M, Kowalczyk P, Bryszewska M, Borowiec M.
    Academic press:
    International Journal of Biological Macromolecules (year: 2016, volume: 88, pages: 156-161), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2016.03.021 – link to the publication

  4. Toxicity and proapoptotic activity of poly(propylene imine) glycodendrimers in vitro: Considering their contrary potential as biocompatible entity and drug molecule in cancer

    Authors:
    Barbara Ziemba, Ida Franiak-Pietryga, Marjorie Pion, Dietmar Appelhans, Maria Ángeles Munoz-Fernández, Brigitte Voit, Maria Bryszewska, Barbara Klajnert-Maculewicz
    Academic press:
    International Journal of Pharmaceutics (year: 2014, volume: 461, pages: 391-402), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2013.12.011 – link to the publication

  5. PPI-G4 glycodendrimers upregulate TRAIL-induced apoptosis in chronic lymphocytic leukemia cells

    Authors:
    Ida Franiak-Pietryga, Maria Bryszewska, Maciej Borowiec, Barbara Ziemba, Michał Bednarek, Małgorzata Misiewicz, Kinga Ostrowska, Henryk Maciejewski
    Status:
    Accepted for publication

Articles in post-conference publications (4)

  1. In vitro evaluation of complexes between modified poly(propylene imine) dendrimers and ananticancer drugcytarabine

    Authors:
    Aleksandra Szulc, Maria Bryszewska, Barbara Klajnert-Maculewicz
    Conference:
    1st International Symposium on Nanoparticles/Nanomaterial and Applications (year: 2014, pages: 77), Publisher: ProteoMass Scientific Society
    Date:
    conference 20 – 22.01.2014
    Status:
    Published
    DOI:
    link to the publication

  2. Nanoparticles – a Novel Approach to Chronic Lymphocytic Leukemia Treatment?

    Authors:
    Ida Franiak-Pietryga, Ewelina Ziolkowska, Barbara Ziemba, Dietmar Appelhans, Brigitte Voit, Joanna Gora-Tybor, Tadeusz Robak, Barbara Klajnert, Maria Bryszewska
    Conference:
    54th ASH Annual Meeting and Exposition (year: 2012, pages: 4601), Publisher: American Society of Hematology
    Date:
    conference 8-11.12.2012
    Status:
    Published
    DOI:
    link to the publication

  3. Blockage of Wnt/B-Catenin signaling by nanoparticles reduces survival and proliferation of CLL cells in vitro.

    Authors:
    Ida Franiak-Pietryga, Henryk Maciejewski, Barbara Ziemba, Dietmar Appelhans, Brigitte Voit, Malgorzata Misiewicz, Tadeusz Robak, Jacek Trelinski, Maria Bryszewska, Maciej Borowiec
    Conference:
    57th Annual Meeting Abstract (year: 2015, pages: 3699), Publisher: American Society of Hematology
    Date:
    conference 5-8.12.2015
    Status:
    Published
    DOI:
    link to the publication

  4. Nonconventional Gene Expression within the NF-kb Signalling Pathway Induced by Poly(propylene) Imine Glycodendrimers in Chronic Lymphocytic Leukemia Cells

    Authors:
    Ida Franiak-Pietryga, Kinga Ostrowska, Dietmar Appelhans, Henryk Maciejewski, Maria Bryszewska, Tadeusz Robak, Jacek Treliński, Maciej Borowiec
    Conference:
    58th Annual Meeting and Exposition of ASH (year: 2016), Publisher: American Society of Hematology
    Status:
    Accepted for publication

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