Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Dendrimers - potential drugs in chronic lymphocytic leukemia

2011/01/B/NZ5/01371

Keywords:

dendrimers chronic lymphocytic leukemia microarrays gene expression profiling

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ1_1: Molecular biology
  • ST5_10: Functional materials/nanomaterials, nanoparticles

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Maria Bryszewska 

Number of co-investigators in the project: 4

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 298 600 PLN

Project start date (Y-m-d): 2011-12-01

Project end date (Y-m-d): 2014-11-30

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Termomikser Comfort 5355 z funkcją grzania i chłodzenia firmy Eppendorf (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. PPI-G4 glycodendrimers upregulate TRAIL-induced apoptosis in chronic lymphocytic leukemia cells
    Authors:
    Ida Franiak-Pietryga, Maria Bryszewska, Maciej Borowiec, Barbara Ziemba, Michał Bednarek, Małgorzata Misiewicz, Kinga Ostrowska, Henryk Maciejewski
    Academic press:
    Macromolecular Bioscience (rok: 2016, ), Wydawca: Wiley-VCH
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  2. Dendrimer-based nanoparticles for potential personalized therapy in chronić lymphocytic leukemia: Targeting the BCR-signaling pathway.
    Authors:
    Franiak-Pietryga I, Maciejewski H, Ostrowska K, Appelhans D, Voit B, Misiewicz M, Kowalczyk P, Bryszewska M, Borowiec M.
    Academic press:
    International Journal of Biological Macromolecules (rok: 2016, tom: 88, strony: 156-161), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2016.03.021 - link to the publication
  3. The Influence of Glycodendrimer on Apoptosis in B-CLL Cells in vitro Defined by Microarrays
    Authors:
    Franiak-Pietryga I, Ziółkowska E, Ziemba B, Appelhans D, Maciejewski H, Voit B, Kaczmarek A, Robak T, Klajnert-Maculewicz B, Cebula-Obrzut B, Smolewski P, Borowiec M, Bryszewska M.
    Academic press:
    Anti-Cancer Agents in Medicinal Chemistry (rok: 2016, tom: 16, strony: -), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    10.2174/1871520616666160622092947 - link to the publication
  4. Toxicity and proapoptotic activity of poly(propylene imine) glycodendrimers in vitro: Considering their contrary potential as biocompatible entity and drug molecule in cancer
    Authors:
    Barbara Ziemba, Ida Franiak-Pietryga, Marjorie Pion, Dietmar Appelhans, Maria Ángeles Munoz-Fernández, Brigitte Voit, Maria Bryszewska, Barbara Klajnert-Maculewicz
    Academic press:
    International Journal of Pharmaceutics (rok: 2014, tom: 461, strony: 391-402), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.ijpharm.2013.12.011 - link to the publication
  5. The Influence of Maltotriose-Modified Poly(propylene imine) Dendrimers on the Chronic Lymphocytic Leukemia Cells in Vitro: Dense Shell G4 PPI.
    Authors:
    Franiak-Pietryga I, Ziółkowska E, Ziemba B, Appelhans D, Voit B, Szewczyk M, Góra-Tybor J, Robak T, Klajnert B, Bryszewska M.
    Academic press:
    Molecular Pharmaceutics (rok: 2013, tom: 10, strony: 2490-2501), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/mp400142p - link to the publication
  1. Blockage of Wnt/B-Catenin signaling by nanoparticles reduces survival and proliferation of CLL cells in vitro.
    Authors:
    Ida Franiak-Pietryga, Henryk Maciejewski, Barbara Ziemba, Dietmar Appelhans, Brigitte Voit, Malgorzata Misiewicz, Tadeusz Robak, Jacek Trelinski, Maria Bryszewska, Maciej Borowiec
    Conference:
    57th Annual Meeting Abstract (rok: 2015, ), Wydawca: American Society of Hematology
    Data:
    konferencja 5-8.12.2015
    Status:
    Published
    DOI:
    link to the publication
  2. Nonconventional Gene Expression within the NF-kb Signalling Pathway Induced by Poly(propylene) Imine Glycodendrimers in Chronic Lymphocytic Leukemia Cells
    Authors:
    Ida Franiak-Pietryga, Kinga Ostrowska, Dietmar Appelhans, Henryk Maciejewski, Maria Bryszewska, Tadeusz Robak, Jacek Treliński, Maciej Borowiec
    Conference:
    58th Annual Meeting and Exposition of ASH (rok: 2016, ), Wydawca: American Society of Hematology
    Data:
    konferencja 3-6.12.2016
    Status:
    Accepted for publication
  3. In vitro evaluation of complexes between modified poly(propylene imine) dendrimers and ananticancer drugcytarabine
    Authors:
    Aleksandra Szulc, Maria Bryszewska, Barbara Klajnert-Maculewicz
    Conference:
    1st International Symposium on Nanoparticles/Nanomaterial and Applications (rok: 2014, ), Wydawca: ProteoMass Scientific Society
    Data:
    konferencja 20 – 22.01.2014
    Status:
    Published
    DOI:
    link to the publication
  4. Nanoparticles – a Novel Approach to Chronic Lymphocytic Leukemia Treatment?
    Authors:
    Ida Franiak-Pietryga, Ewelina Ziolkowska, Barbara Ziemba, Dietmar Appelhans, Brigitte Voit, Joanna Gora-Tybor, Tadeusz Robak, Barbara Klajnert, Maria Bryszewska
    Conference:
    54th ASH Annual Meeting and Exposition (rok: 2012, ), Wydawca: American Society of Hematology
    Data:
    konferencja 8-11.12.2012
    Status:
    Published
    DOI:
    link to the publication

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