Computational study of conformational and thermodynamic properties of human ribosomal A-site and its interactions with aminoglycoside antibiotics.
2011/01/N/NZ1/01558
Keywords
Descriptors
- NZ1_1: Biologia molekularna
- NZ1_3: Biofizyka
- NZ2_8: Biologia obliczeniowa
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Uniwersytet Warszawski, Interdyscyplinarne Centrum Modelowania Matematycznego i Komputerowego
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 1 – announced on 2011-03-15
- Amount awarded
- 57 750 PLN
- Project start date
- 2011-12-06
- Project end date
- 2014-01-05
- Project duration
- 25 months (the same as in the proposal)
- Project status
- Project settled
Equipment purchased [PL]
- komputer przenośny. Cost: 2 730 PLN
- wielordzeniowa stacja robocza. Cost: 4 600 PLN
Information in the final report
Publication in academic press/journals (3)
-
Role of S-turn2 in the Structure, Dynamics, and Function of Mitochondrial Ribosomal A-Site. A Bioinformatics and Molecular Dynamics Simulation Study
- Authors:
- Joanna Panecka, Marek Havrila, Kamila Réblová, Jiri Šponer, Joanna Trylska
- Academic press:
- Journal of Physical Chemistry B (year: 2014, volume: 118, pages: 6687-6701), Publisher: American Chemical Society
- Status:
- Published
- DOI:
- 10.1021/jp5030685 – link to the publication
-
Interplay of the Bacterial Ribosomal A-Site, S12 Protein Mutations and Paromomycin Binding: A Molecular Dynamics Study
- Authors:
- Joanna Panecka, Cameron Mura, Joanna Trylska
- Academic press:
- PLOS ONE (year: 2014, volume: 9, pages: e111811), Publisher: Public Library of Science
- Status:
- Published
- DOI:
- 10.1371/journal.pone.0111811 – link to the publication
-
Conformational dynamics of bacterial and human cytoplasmic models of the ribosomal A-site
- Authors:
- Joanna Panecka, Jiří Šponer, Joanna Trylska
- Academic press:
- Biochimie (year: 2015, volume: 112, pages: 96-110), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.biochi.2015.02.021 – link to the publication
Articles in post-conference publications (1)
-
Molecular Dynamics Techniques in the Studies of the Bacterial Ribosome
- Authors:
- Joanna Panecka, Joanna Trylska
- Conference:
- Theory and Applications of Computational Chemistry (TACC-2012) (year: 2012, pages: 207-214), Publisher: AIP Publishing LLC
- Date:
- conference 2-7.09.2012
- Status:
- Published
- DOI:
- link to the publication