Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of Pregnane-X-receptor (PXR) in the pathogenesis of primary sclerosing cholangitis (PSC)

2011/01/B/NZ5/04216

Keywords:

liver diseases cholestasis primary sclerosing cholangitis primary biliary cirrhosis nuclear orphan receptors

Descriptors:

  • NZ5_3: Pathogenesis of human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Piotr Milkiewicz 

Number of co-investigators in the project: 5

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 377 000 PLN

Project start date (Y-m-d): 2011-12-12

Project end date (Y-m-d): 2015-09-11

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Notebook (5 000 PLN)
  2. Cyfrowy system dokumentacji naukowej.
  3. Kriostat (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (1)
  1. Prospective evaluation of ursodeoxycholic acid withdrawal in patients with primary sclerosing cholangitis.
    Authors:
    Wunsch E, Trottier J, Milkiewicz M, Raszeja-Wyszomirska J, Hirschfield GM, Barbier O, Milkiewicz P.
    Academic press:
    Hepatology (rok: 2014, tom: 60, strony: 931-940), Wydawca: American Association for the Study of Liver Diseases
    Status:
    Published
    DOI:
    10.1002/hep.27074 - link to the publication
  2. Impaired Hepatic Adaptation to Chronic Cholestasis induced by Primary Sclerosing Cholangitis (PSC)
    Authors:
    Malgorzata Milkiewicz , Marta Klak, Agnieszka Kempińska-Podhorodecka, Elzbieta Urasinska, Ewa Wunsch , Elwyn Elias, Piotr Milkiewicz
    Academic press:
    Scientific Reports (rok: 2016, ), Wydawca: Nature Publishing Group
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  3. Liver expression of sulphotransferase 2A1 enzyme is impaired in patients with primary sclerosing cholangitis: lack of the response to enhanced expression of PXR.
    Authors:
    Ewa Wunsch, Marta Klak, Urszula Wasik, Małgorzata Milkiewicz, Małgorzata Blatkiewicz, Elżbieta Urasińska, Olivier Barbier, Dariusz Bielicki, Dimitrios P. Bogdanos, Elwyn Elias, Piotr Milkiewicz.
    Academic press:
    J. Immunol. Res. (rok: 2015, tom: ID 571353, strony: 8 s), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2015/571353 - link to the publication
  4. Errata do publikacji: Role of Glucuronidation for Hepatic Detoxification and Urinary Elimination of Toxic Bile Acids during Biliary Obstruction
    Authors:
    Martin Perreault, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Piotr Milkiewicz, Olivier Barbier
    Academic press:
    PLoS One (rok: 2013, tom: 8, strony: e80994, 9 s), Wydawca: PLoS
    Status:
    Published
    DOI:
    10.1371/annotation/ef13ed51-6848-419d-94d8-1bb62e7bcf52 - link to the publication
  5. PR3-ANCA: A Promising Biomarker in Primary Sclerosing Cholangitis (PSC)
    Authors:
    Laura M. Stinton, Chelsea Bentow, Michael Mahler, Gary L. Norman , Bertus Eksteen, Andrew L. Mason, Gilaad G. Kaplan, Bjorn Lindkvist, Gideon M. Hirschfield, Piotr Milkiewicz, Angela Cheung, Harry L. A. Janssen, Marvin J. Fritzler
    Academic press:
    PLoS One (rok: 2014, tom: 14, strony: 8), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0112877 - link to the publication
  6. Role of Glucuronidation for Hepatic Detoxification and Urinary Elimination of Toxic Bile Acids during Biliary Obstruction
    Authors:
    Martin Perreault, Andrzej Białek, Jocelyn Trottier, Mélanie Verreault, Patrick Caron, Piotr Milkiewicz, Olivier Barbier
    Academic press:
    PLoS ONE (rok: 2013, tom: 8, strony: e80994, 9 s), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0080994 - link to the publication
  7. Serum autotaxin is a marker of severity of liver injury and overall survival in patients with cholestatic liver diseases.
    Authors:
    Ewa Wunsch, Marcin Krawczyk, Malgorzata Milkiewicz, Jocelyn Trottier, Olivier Barbier, Markus Neurath, Frank Lammert, Andreas E. Kremer, Piotr Milkiewicz
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: 12s), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep30847 - link to the publication
  1. Adaptive mechanisms in chronic cholestasis in humans: changes in the expression of nuclear receptors and sulphotransferase 2A1
    Authors:
    Wunsch E., Blatkiewicz M., Klak M., Barbier O., Bogdanos D.P., Milkiewicz M., Elias E., Milkiewicz P.
    Conference:
    European Association for the Study of the Liver, Monothematic Conference: Primary biliary cirrhosis (PBC) (rok: 2014, ), Wydawca: European Association for the Study of the Liver
    Data:
    konferencja 23-24.05.2014
    Status:
    Published

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