Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The synthesis and physicochemical analiysis of new delivery systems for gene therapy and siRNA transfection

2011/01/B/ST5/00846

Keywords:

drug delivery systems siRNA dicationic surfactants

Descriptors:

  • ST4_3: Molecular architecture and structure
  • ST5_16:
  • ST5_1: Structural properties of materials

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet im. Adama Mickiewicza, Wydział Fizyki

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Maciej Kozak 

Number of co-investigators in the project: 8

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 567 000 PLN

Project start date (Y-m-d): 2011-12-12

Project end date (Y-m-d): 2015-08-11

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Przystawka spektrofotometryczna do pomiarów dichroizmu kołowego. (190 000 PLN)

Information in the final report

  • Publication in academic press/journals (11)
  • Articles in post-conference publications (21)
  1. Structural studies of the formation of lipoplexes between siRNA and selected bis-imidazolium gemini surfactants
    Authors:
    Weronika Andrzejewska, Zuzanna Pietralik, Michalina Skupin, Maciej Kozak
    Academic press:
    Soft Matter (rok: 2015, tom: x, strony: 45300), Wydawca: Royal Society of Chemistry
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Interaction of Bovine Serum Albumin (BSA) with Novel Gemini Surfactants Studied by Synchrotron Radiation Scattering (SRSAXS), Circular Dichroism (CD) and Nuclear Magnetic Resonance (NMR)
    Authors:
    Witold Gospodarczyk, Kosma Szutkowski, Maciej Kozak
    Academic press:
    J. Phys. Chem B, (rok: 2014, tom: 118, strony: 8652−8661), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/jp5047485 - link to the publication
  3. Interaction of two imidazolium gemini surfactants with two model proteins BSA and HEWL
    Authors:
    Witold Gospodarczyk, Maciej Kozak
    Academic press:
    Colloid and Polymer Science (rok: 2015, tom: 293, strony: 2855-2866), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00396-015-3671-z - link to the publication
  4. Structural and spectroscopic studies of formation lipoplexes between dna and cationic gemini surfactants
    Authors:
    Weronika Andrzejewska, Zuzanna Pietralik, Michał Taube, Andrzej Skrzypczak, Maciej Kozak
    Academic press:
    Polimery (rok: 2014, tom: 41828, strony: 569-574), Wydawca: Instytut Chemii Przemysłowej im. prof. Ignacego Mościckiego
    Status:
    Published
    DOI:
    10.14314/polimery.2014.569 - link to the publication
  5. The influence of novel gemini surfactants containing cycloalkyl side-chains on the structural phases of DNA in solution
    Authors:
    Zuzanna Pietralik, Janet Kumita, Christopher Dobson, Maciej Kozak
    Academic press:
    Colloid and Surfaces B: Biointerfaces (rok: 2015, tom: 131, strony: 83–92), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2015.04.042 - link to the publication
  6. Dicationic surfactants with glycine counterions for oligonucleotides transportation
    Authors:
    Zuzanna Pietralik, Andrzej Skrzypczak, Maciej Kozak
    Academic press:
    ChemPhysChem (rok: 2016, tom: x, strony: 45303), Wydawca: Wiley
    Status:
    Submitted
    DOI:
    brak - link to the publication
  7. The study of complexation between dicationic surfactants and the DNA duplex using structural and spectroscopic methods
    Authors:
    Weronika Andrzejewska, Michalina Skupin, Magdalena Murawska, Maciej Kozak
    Academic press:
    Biomacromolecules (rok: 2015, tom: x, strony: 12420), Wydawca: ACS
    Status:
    Submitted
    DOI:
    brak - link to the publication
  8. Structure and Conformational Dynamics of DMPC/Dicationic Surfactant and DMPC/Dicationic Surfactant/DNA Systems.
    Authors:
    Zuzanna Pietralik, Rafał Krzysztoń, Wojciech Kida, Weronika Andrzejewska and Maciej Kozak
    Academic press:
    Int. J. Mol. Sci. (rok: 2013, tom: 14, strony: 7642-7659), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms14047642 - link to the publication
  9. The system with zwitterionic lactose-based surfactant for complexation and delivery of siRNA
    Authors:
    Michalina Skupin, Krzysztof Sobczak, Ryszard Zieliński, Maciej Kozak
    Academic press:
    Biophysical Journal (rok: 2015, tom: x, strony: 45307), Wydawca: BPS
    Status:
    Submitted
    DOI:
    brak - link to the publication
  10. Understanding the aggregation and pre-micellization phenomena of bis-imidazolium gemini surfactants in aqueous solutions
    Authors:
    Kosma Szutkowski, Zuzanna Pietralik, Igor Zhukov, Maciej Kozak,
    Academic press:
    Langmuir (rok: 2015, tom: x, strony: 45320), Wydawca: ACS
    Status:
    Submitted
    DOI:
    brak - link to the publication
  11. Gemini surfactants based on bis-imidazolium alkoxy derivatives as effective agents for delivery of nucleic acids: a structural and spectroscopic study
    Authors:
    Zuzanna Pietralik, Żaneta Kołodziejska, Marek Weiss, Maciej Kozak
    Academic press:
    PLOS one (rok: 2015, tom: 10 (12), strony: e0144373), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0144373 - link to the publication
  1. Gemini surfactant as effective agents for delivery of nucleic acids
    Authors:
    Żaneta Kołodziejska, Zuzanna Pietralik, Marek Weiss and Maciej Kozak
    Conference:
    ISSRNS 2014 (rok: 2014, ), Wydawca: PTPS, czasopismo: Synchrotron Radiation in Natural Science Vol. 13, No. 1-2
    Data:
    konferencja 15 - 20/06/2014
    Status:
    Published
    DOI:
    link to the publication
  2. Interaction of selected gemini surfactants with two model proteins: BSA and HEWL
    Authors:
    Witold Gospodarczyk, Maciej Kozak
    Conference:
    ISSRNS 2014 (rok: 2014, ), Wydawca: PTPS, czasopismo: Synchrotron Radiation in Natural Science Vol. 13, No. 1-2
    Data:
    konferencja 15 - 20/06/2014
    Status:
    Published
    DOI:
    link to the publication
  3. COMPLEXATION OF NUCLEIC ACIDS BY CATIONIC GEMINI SURFACTANT
    Authors:
    Zuzanna Pietralik and Maciej Kozak
    Conference:
    ISSRNS 2012 (rok: 2012, ), Wydawca: PTPS; czasopismo: Synchrotron Radiation in Natural Science Vol. 11, No 1-2 (2012)
    Data:
    konferencja 20-25 maja 2012
    Status:
    Published
    DOI:
    link to the publication
  4. The Study of Complexation Process between Cationic Gemini Surfactants and DNA using Structural and Spectroscopic Methods
    Authors:
    Andrzejewska, Weronika J.; Skupin, Michalina; Murawska, Magdalena; Skrzypczak, Andrzej; Kozak, Maciej
    Conference:
    59th Biophysical Society Meeting (rok: 2015, ), Wydawca: BPS; Biophysical Journal, vol. 108, issue 2, pp. 392a-393a
    Data:
    konferencja 7-11/02/2015
    Status:
    Published
    DOI:
    link to the publication
  5. The dynamics of micellization of gemini imidazolium surfactants studied by NMR, FT-IR and SAXS
    Authors:
    Kosma Szutkowski, Zuzanna Pietralik, Maciej Kozak
    Conference:
    11 KSUPS (rok: 2015, ), Wydawca: PTPS; czasopismo: Synchrotron Radiation in Natural Science Vol. 14, No 1-2 (2015)
    Data:
    konferencja 1-4 września
    Status:
    Published
  6. SPECTROSCOPIC AND STRUCTURAL STUDIES OF INTERACTIONS BETWEEN GEMINI SURFACTANTS AND PHOSPHATIDYLOCHOLINE DERIVATIVES
    Authors:
    Zuzanna Pietralik, Monika Krecicz, Maciej Kozak
    Conference:
    ISSRNS 2012 (rok: 2012, ), Wydawca: PTPS; czasopismo: Synchrotron Radiation in Natural Science Vol. 11, No 1-2 (2012)
    Data:
    konferencja 20-25 maja 2012
    Status:
    Published
    DOI:
    link to the publication
  7. Studies od dsDNA and siRNA oligomers in complexes with tricationic surfactants using biophysical methods
    Authors:
    Weronika Andrzejewska, Michalina Skupin, Maciej Kozak
    Conference:
    11 KSUPS (rok: 2015, ), Wydawca: PTPS; czasopismo: Synchrotron Radiation in Natural Science Vol. 14, No 1-2 (2015)
    Data:
    konferencja 1-4 września
    Status:
    Published
  8. Difference in structure and conformational dynamics of DPPC and DPPC/DNA systems with selected gemini surfactants with different spacer
    Authors:
    W. Kida, M. Kozak
    Conference:
    KSUPS2013 (rok: 2013, ), Wydawca: PTPS, czasopismo: Synchrotron Radiation in Natural Science Vol. 12, No 1-2 (2013)
    Data:
    konferencja 9-11/09/2013
    Status:
    Published
    DOI:
    link to the publication
  9. Influence of selected gemini surfactants and sulfobetaines on structure of BSA and lysozyme
    Authors:
    W. Gospodarczyk, M. Kozak
    Conference:
    KSUPS2013 (rok: 2013, ), Wydawca: PTPS, czasopismo: Synchrotron Radiation in Natural Science Vol. 12, No 1-2 (2013)
    Data:
    konferencja 9-11/09/2013
    Status:
    Published
    DOI:
    link to the publication
  10. STRUCTURAL ANALYSIS OF SELECTED GEMINI SURFACTANT (1-IMIDAZOLILO-3-DECYLOOXYMETHYL) PENTANE CHLORIDE LIPOPLEXES
    Authors:
    Zuzanna Pietralik, Rafał Krzyszton, Maciej Kozak
    Conference:
    ISSRNS 2012 (rok: 2012, ), Wydawca: PTPS; czasopismo: Synchrotron Radiation in Natural Science Vol. 11, No 1-2 (2012)
    Data:
    konferencja 20-25 maja 2012
    Status:
    Published
    DOI:
    link to the publication
  11. Structural and spectroscopic studies of nanosystems based on gemini surfactants as innovative delivery systems in gene therapy
    Authors:
    Weronika Andrzejewska, Maciej Kozak
    Conference:
    BIO Congress Warsaw, Poland September 9th–12th 2014 (rok: 2014, ), Wydawca: Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 9-12/09/2014
    Status:
    Published
    DOI:
    link to the publication
  12. Trimeric surfactants - new effective carriers for gene therapy
    Authors:
    Żaneta Kołodziejska, Zuzanna Pietralik, Maciej Kozak
    Conference:
    11 KSUPS (rok: 2015, ), Wydawca: PTPS; czasopismo: Synchrotron Radiation in Natural Science Vol. 14, No 1-2 (2015)
    Data:
    konferencja 1-4 września
    Status:
    Published
  13. Complexes between DNA and selected gemini surfactants – circular dichroism and AFM studies
    Authors:
    Ż. Kołodziejska, Z. Pietralik, M. Kozak
    Conference:
    KSUPS2013 (rok: 2013, ), Wydawca: PTPS, czasopismo: Synchrotron Radiation in Natural Science Vol. 12, No 1-2 (2013)
    Data:
    konferencja 9-11/09/2013
    Status:
    Published
    DOI:
    link to the publication
  14. Structural and spectroscopic studies of formation lipoplexes between DNA and cationic gemini surfactants
    Authors:
    Weronika Andrzejewska, Żaneta Kołodziejska, Maciej Kozak
    Conference:
    9th International Conference on X-Ray Investigation of Polymer Structure (rok: 2013, ), Wydawca: ATH Bielsko Biała
    Data:
    konferencja Zakopane 3-6/12/2013
    Status:
    Published
  15. Structural studies of nanosystems based on zwitterionic sugar-based surfactants as innovative gene delivery systems
    Authors:
    Michalina Skupin, Zuzanna Pietralik, Krzysztof Sobczak, Ryszard Zieliński, Maciej Kozak
    Conference:
    11 KSUPS (rok: 2015, ), Wydawca: PTPS; czasopismo: Synchrotron Radiation in Natural Science Vol. 14, No 1-2 (2015)
    Data:
    konferencja 1-4 września
    Status:
    Published
  16. Structural studies of nanosystems for gene therapy
    Authors:
    Maciej Kozak, Zuzanna Pietralik, Wojciech Kida, Weronika Andrzejewska, Żaneta Kołodziejska
    Conference:
    9th International Conference on X-Ray Investigation of Polymer Structure, (rok: 2013, ), Wydawca: ATH Bielsko Biała
    Data:
    konferencja Zakopane 3-6/12/2013
    Status:
    Published
  17. Studies of selected gemini surfactants complexes with DNA and siRNA using biophysical methods
    Authors:
    W.J. Andrzejewska, Z. Pietralik, M. Taube, M. Kozak
    Conference:
    KSUPS2013 (rok: 2013, ), Wydawca: PTPS, czasopismo: Synchrotron Radiation in Natural Science Vol. 12, No 1-2 (2013)
    Data:
    konferencja 9-11/09/2013
    Status:
    Published
    DOI:
    link to the publication
  18. The SAXS studies of complexation dicationic gemini surfactants with low molecular nucleic acids DNA and siRNA.
    Authors:
    Weronika Andrzejewska, Michalina Skupin, Maciej Kozak
    Conference:
    ISSRNS 2014 (rok: 2014, ), Wydawca: PTPS, czasopismo: Synchrotron Radiation in Natural Science Vol. 13, No. 1-2
    Data:
    konferencja 15 - 20/06/2014
    Status:
    Published
    DOI:
    link to the publication
  19. The influence of selected gemini surfactants on the structural forms of DNA in solution
    Authors:
    Zuzanna Pietalik, Maciej Kozak
    Conference:
    9th International Conference on X-Ray Investigation of Polymer Structure (rok: 2013, ), Wydawca: ATH Bielsko Biała
    Data:
    konferencja Zakopane, 3-6/12/2013
    Status:
    Published
  20. Wpływ rodzaju grupy hydrofilowej surfaktantów gemini na ich zdolność kompleksowania oligomerów siRNA
    Authors:
    Weronika Andrzejewska, Michalina Skupin, Magdalena Murawska, Zuzanna Pietralik, Maciej Kozak
    Conference:
    57 Konwersatorium Krystalograficzne , r (rok: 2015, ), Wydawca: PTK
    Data:
    konferencja 24 – 26 VI
    Status:
    Published
  21. Wpływ surfaktantów dikationowych na strukturę drugorzędową i hydratację BSA
    Authors:
    Witold Gospodarczyk, Kosma Szutkowski, Maciej Kozak
    Conference:
    XLII Zjazd Fizyków Polskich (rok: 2013, ), Wydawca: Wydz. Fiz. Tech. Pol. Pozn.
    Data:
    konferencja 8-13/09/2013
    Status:
    Published

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