Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The impact of curcumin on in vitro senescence of vascular smooth muscle and endothelial cells derived from aorta

2011/01/B/NZ3/02137

Keywords:

curcumin cellular senescence VSMC EC angiotensin II inflammation

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_4: Ageing

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Anna Bielak-Żmijewska 

Number of co-investigators in the project: 6

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 716 000 PLN

Project start date (Y-m-d): 2011-12-07

Project end date (Y-m-d): 2014-12-06

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. zestaw do Western blottingu.
  2. kołyska laboratoryjna (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (9)
  1. Rola starzenia komórkowego w starzeniu organizmu i chorobach związanych z wiekiem.
    Authors:
    Bielak-Zmijewska A, Grabowska W, Przybylska D.
    Academic press:
    Postępy biochemii (rok: 2014, tom: 60(2), strony: 147-60), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  2. The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes.
    Authors:
    Alster O, Bielak-Zmijewska A, Mosieniak G, Moreno-Villanueva M, Dudka-Ruszkowska W, Wojtala A, Kusio-Kobiałka M, Korwek Z, Burkle A, Piwocka K, Siwicki JK, Sikora E
    Academic press:
    PLOS ONE. (rok: 2014, tom: 9(8), strony: E104964), Wydawca: www.plosone.org
    Status:
    Published
    DOI:
    10.1371/journal.pone.0104964 - link to the publication
  3. A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta
    Authors:
    Anna Bielak-Zmijewska • Maciej Wnuk • Dorota Przybylska • Wioleta Grabowska • Anna Lewinska • Olga Alster • Zbigniew Korwek • Anna Cmoch • Aleksander Myszka • Slawomir Pikula • Grazyna Mosieniak • Ewa Sikora
    Academic press:
    Biogerontology (rok: 2014, tom: 15, strony: 47-64), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10522-013-9477-9 - link to the publication
  4. Cellular senescence in ageing, age-related disease and longevity.
    Authors:
    Sikora E, Bielak-Zmijewska A, Mosieniak G.
    Academic press:
    CURR VASC PHARMACOL. (rok: 2014, tom: 12(5), strony: 698-706), Wydawca: Bentham Science
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells
    Authors:
    Anna Lewinska; Maciej Wnuk; Wioleta Grabowska; Tomasz Zabek; Ewelina Semik; Ewa Sikora; Anna Bielak-Zmijewska
    Academic press:
    Toxicology Letters (rok: 2015, tom: -, strony: -), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.toxlet.2015.01.019. - link to the publication
  6. Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM independent manner.
    Authors:
    Wioleta Grabowska, Karolina Kucharewicz, Maciej Wnuk, Anna Lewinska, Małgorzata Suszek, Dorota Przybylska, Grazyna Mosieniak, Ewa Sikora, Anna Bielak-Zmijewska
    Academic press:
    AGE (rok: 2014, tom: -, strony: -), Wydawca: Springer
    Status:
    Accepted for publication
    DOI:
    10.1007/s11357-014-9744-y - link to the publication
  1. Curcumin induces cellular senescence of vascular smooth muscle cells: the role of DNA damage and ROS production
    Authors:
    Wioleta Grabowska, Ewa Sikora, Anna Bielak-Zmijewska
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology,Biophysics and Bioinformatics, BIO 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09.2014 Warszawa, Polska
    Status:
    Published
  2. How curcumin induces senescence of vascular smooth muscle cells - searching for the mechanism
    Authors:
    Grabowska W., Sikora E., Bielak-Zmijewska A.
    Conference:
    50th FEBS EMBO 2014 Conference, (rok: 2014, ), Wydawca: wiley
    Data:
    konferencja 30.08.-04.09.
    Status:
    Published
    DOI:
    link to the publication
  3. Is nibrin essential for the induction of premature senescence?
    Authors:
    O Alster , A Bielak-Zmijewska, G Mosieniak, M Moreno-Villanueva, W Dudka- Ruszkowska, A Wojtala, M Kusio-Kobialka, Z Korwek, A Burkle K Piwocka, JK Siwicki, E Sikora
    Conference:
    30th Ernst Klenk Symposium in Molecular Medicine "DNA Damage Response and Repair Mechanisms in Aging and Disease" (rok: 2014, ), Wydawca: -
    Data:
    konferencja 21-23.09. 2014 Kolonia, Niemcy
    Status:
    Published
    DOI:
    link to the publication
  4. Curcumin induces oxidative-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells
    Authors:
    Anna Lewinska, Maciej Wnuk, Wioleta Grabowska, Tomasz Zabek, Ewelina Semik, Ewa Sikora, Anna Bielak-Zmijewska
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology,Biophysics and Bioinformatics, BIO 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09.Warszawa, Polska
    Status:
    Published
  5. The role of nibrin in doxorubicininduced senescence of primary cells and T lymphocytes derived from Nijmegen Breakage Syndrome patients
    Authors:
    Olga Alster, Anna Bielak-Zmijewska, Grazyna Mosieniak, Maria Moreno-Villanueva, Wioleta Dudka-Ruszkowska, Monika Kusio-Kobiałka, Zbigniew Korwek, Alexander Burkle, Katarzyna Piwocka, Jan K. Siwicki, Ewa Sikora
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology,Biophysics and Bioinformatics, BIO 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09.Warszawa, Polska
    Status:
    Published
  6. Induction of senescence of vascular smooth muscle cells by cytostatic dose of curcumin.
    Authors:
    W. Grabowska, E. Sikora, A. Bielak-Żmijewska
    Conference:
    3rd IRB Barcelona International PhD Student Symposium: The clock of life- cellular and molecular processes of development, ageing and disease (rok: 2013, ), Wydawca: Institute for Researcyh in Biomedicine
    Data:
    konferencja 14-15.11
    Status:
    Published
    DOI:
    link to the publication
  7. The impact of curcumin on the level of sirtuins 1 and 6 and DNA damage in endothelial cells derived from human aorta
    Authors:
    Małgorzata Suszek, Karolina Kucharewicz, Ewa Sikora, Anna Bielak-Zmijewska
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology,Biophysics and Bioinformatics, BIO 2014 (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12.09.2014 Warszawa, Polska
    Status:
    Published
  8. Hallmarks of replicative and stress-induced human vascular smooth muscle cells senescence
    Authors:
    Dorota Przybylska, Anna Bielak-Żmijewska, Anna Ćmoch, Sławomir Pikuła, Zbigniew Korwek, Olga Alster, Halina Waś, Wioleta Grabowska, Ewa Sikora, Grażyna Mosieniak
    Conference:
    47th Congres of the Polish Biochemical Society, Polish-German Biochemical Societies Joint Meeting (rok: 2012, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 11-14 września
    Status:
    Published
  9. Replicative and premature senescence of human vascular smooth muscle cells
    Authors:
    Anna Bielak-Żmijewska, Zbigniew Korwek, Olga Alster, Grażyna Mosieniak, Dorota Przybylska, Wioleta Grabowska, Anna Ćmoch, Sławomir Pikuła, Ewa Sikora
    Conference:
    47th Congres of the Polish Biochemical Society, Polish-German Biochemical Societies Joint Meeting (rok: 2012, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 11-14 września
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy