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The impact of curcumin on in vitro senescence of vascular smooth muscle and endothelial cells derived from aorta

2011/01/B/NZ3/02137

Keywords

Descriptors

  • NZ3_1: Biologia komórki
  • NZ3_4: Starzenie

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Anna Bielak-Żmijewska

Number of co-investigators in the project: 6

Call

OPUS 1 – announced on 2011-03-15

Amount awarded
716 000 PLN
Project start date
2011-12-07
Project end date
2014-12-06
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. kołyska laboratoryjna. Cost: 10 000 PLN
  2. zestaw do Western blottingu.

Information in the final report

Publication in academic press/journals (6)

  1. The role of nibrin in doxorubicin-induced apoptosis and cell senescence in Nijmegen Breakage Syndrome patients lymphocytes.

    Authors:
    Alster O, Bielak-Zmijewska A, Mosieniak G, Moreno-Villanueva M, Dudka-Ruszkowska W, Wojtala A, Kusio-Kobiałka M, Korwek Z, Burkle A, Piwocka K, Siwicki JK, Sikora E
    Academic press:
    PLOS ONE. (year: 2014, volume: 9(8), pages: E104964), Publisher: www.plosone.org
    Status:
    Published
    DOI:
    10.1371/journal.pone.0104964 – link to the publication

  2. Cellular senescence in ageing, age-related disease and longevity.

    Authors:
    Sikora E, Bielak-Zmijewska A, Mosieniak G.
    Academic press:
    CURR VASC PHARMACOL. (year: 2014, volume: 12(5), pages: 698-706), Publisher: Bentham Science
    Status:
    Published

  3. Rola starzenia komórkowego w starzeniu organizmu i chorobach związanych z wiekiem.

    Authors:
    Bielak-Zmijewska A, Grabowska W, Przybylska D.
    Academic press:
    Postępy biochemii (year: 2014, volume: 60(2), pages: 147-60), Publisher: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    link to the publication

  4. A comparison of replicative senescence and doxorubicin-induced premature senescence of vascular smooth muscle cells isolated from human aorta

    Authors:
    Anna Bielak-Zmijewska • Maciej Wnuk • Dorota Przybylska • Wioleta Grabowska • Anna Lewinska • Olga Alster • Zbigniew Korwek • Anna Cmoch • Aleksander Myszka • Slawomir Pikula • Grazyna Mosieniak • Ewa Sikora
    Academic press:
    Biogerontology (year: 2014, volume: 15, pages: 47-64), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s10522-013-9477-9 – link to the publication

  5. Curcumin induces senescence of primary human cells building the vasculature in a DNA damage and ATM independent manner.

    Authors:
    Wioleta Grabowska, Karolina Kucharewicz, Maciej Wnuk, Anna Lewinska, Małgorzata Suszek, Dorota Przybylska, Grazyna Mosieniak, Ewa Sikora, Anna Bielak-Zmijewska
    Status:
    Accepted for publication

  6. Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells

    Authors:
    Anna Lewinska; Maciej Wnuk; Wioleta Grabowska; Tomasz Zabek; Ewelina Semik; Ewa Sikora; Anna Bielak-Zmijewska
    Status:
    Accepted for publication

Articles in post-conference publications (9)

  1. Curcumin induces oxidative-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells

    Authors:
    Anna Lewinska, Maciej Wnuk, Wioleta Grabowska, Tomasz Zabek, Ewelina Semik, Ewa Sikora, Anna Bielak-Zmijewska
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology,Biophysics and Bioinformatics, BIO 2014 (year: 2014, pages: plakat P8.10), Publisher: Acta Biochimica Polonica
    Date:
    conference 9-12.09.Warszawa, Polska
    Status:
    Published

  2. How curcumin induces senescence of vascular smooth muscle cells - searching for the mechanism

    Authors:
    Grabowska W., Sikora E., Bielak-Zmijewska A.
    Conference:
    50th FEBS EMBO 2014 Conference, (year: 2014, pages: Książka abstraktów (plakat) SUN-026), Publisher: wiley
    Date:
    conference 30.08.-04.09.
    Status:
    Published
    DOI:
    link to the publication

  3. Is nibrin essential for the induction of premature senescence?

    Authors:
    O Alster , A Bielak-Zmijewska, G Mosieniak, M Moreno-Villanueva, W Dudka- Ruszkowska, A Wojtala, M Kusio-Kobialka, Z Korwek, A Burkle K Piwocka, JK Siwicki, E Sikora
    Conference:
    30th Ernst Klenk Symposium in Molecular Medicine DNA Damage Response and Repair Mechanisms in Aging and Disease (year: 2014, pages: plakat B-1), Publisher: -
    Date:
    conference 21-23.09. 2014 Kolonia, Niemcy
    Status:
    Published

  4. The role of nibrin in doxorubicininduced senescence of primary cells and T lymphocytes derived from Nijmegen Breakage Syndrome patients

    Authors:
    Olga Alster, Anna Bielak-Zmijewska, Grazyna Mosieniak, Maria Moreno-Villanueva, Wioleta Dudka-Ruszkowska, Monika Kusio-Kobiałka, Zbigniew Korwek, Alexander Burkle, Katarzyna Piwocka, Jan K. Siwicki, Ewa Sikora
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology,Biophysics and Bioinformatics, BIO 2014 (year: 2014, pages: plakat P8.1), Publisher: Acta Biochimica Polonica
    Date:
    conference 9-12.09.Warszawa, Polska
    Status:
    Published

  5. Curcumin induces cellular senescence of vascular smooth muscle cells: the role of DNA damage and ROS production

    Authors:
    Wioleta Grabowska, Ewa Sikora, Anna Bielak-Zmijewska
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology,Biophysics and Bioinformatics, BIO 2014 (year: 2014, pages: plakat P8.4), Publisher: Acta Biochimica Polonica
    Date:
    conference 9-12.09.2014 Warszawa, Polska
    Status:
    Published

  6. Replicative and premature senescence of human vascular smooth muscle cells

    Authors:
    Anna Bielak-Żmijewska, Zbigniew Korwek, Olga Alster, Grażyna Mosieniak, Dorota Przybylska, Wioleta Grabowska, Anna Ćmoch, Sławomir Pikuła, Ewa Sikora
    Conference:
    47th Congres of the Polish Biochemical Society, Polish-German Biochemical Societies Joint Meeting (year: 2012, pages: Vol. 59 Supplement 3/2012, str 8), Publisher: Acta Biochimica Polonica
    Date:
    conference 11-14 września
    Status:
    Published

  7. Hallmarks of replicative and stress-induced human vascular smooth muscle cells senescence

    Authors:
    Dorota Przybylska, Anna Bielak-Żmijewska, Anna Ćmoch, Sławomir Pikuła, Zbigniew Korwek, Olga Alster, Halina Waś, Wioleta Grabowska, Ewa Sikora, Grażyna Mosieniak
    Conference:
    47th Congres of the Polish Biochemical Society, Polish-German Biochemical Societies Joint Meeting (year: 2012, pages: Vol. 59 Supplement 3/2012, 17), Publisher: Acta Biochimica Polonica
    Date:
    conference 11-14 września
    Status:
    Published

  8. Induction of senescence of vascular smooth muscle cells by cytostatic dose of curcumin.

    Authors:
    W. Grabowska, E. Sikora, A. Bielak-Żmijewska
    Conference:
    3rd IRB Barcelona International PhD Student Symposium: The clock of life- cellular and molecular processes of development, ageing and disease (year: 2013, pages: P25), Publisher: Institute for Researcyh in Biomedicine
    Date:
    conference 14-15.11
    Status:
    Published

  9. The impact of curcumin on the level of sirtuins 1 and 6 and DNA damage in endothelial cells derived from human aorta

    Authors:
    Małgorzata Suszek, Karolina Kucharewicz, Ewa Sikora, Anna Bielak-Zmijewska
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology,Biophysics and Bioinformatics, BIO 2014 (year: 2014, pages: plakat P8.19), Publisher: Acta Biochimica Polonica
    Date:
    conference 9-12.09.2014 Warszawa, Polska
    Status:
    Published

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