Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The effect of the lipoic acid nitroglycerin on the activity of aldehyde dehydrogenase. Impilication for broadening of pharmacological activity spectrum of lipoic acid and nitroglycerin - a new face of old drugs

2011/01/B/NZ4/01675

Keywords:

lipoic acid nitroglycerin disulfiram aldehyde dehydrogenase

Descriptors:

  • NZ1_2:
  • NZ4_17:
  • NZ4_16:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński- Collegium Medicum, Collegium Medicum; Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Lidia Włodek 

Number of co-investigators in the project: 5

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 304 400 PLN

Project start date (Y-m-d): 2011-12-16

Project end date (Y-m-d): 2015-12-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Zamrażarka niskotemperaturowa (25 000 PLN)
  2. pipeta automatyczna.
  3. Ręczny licznik komórek (14 000 PLN)
  4. Homogenizator laboratoryjny z końcówkami homogenizującymi (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (14)
  1. Inactivation of aldehyde dehydrogenase by nitroglycerin in the presence and absence of lipoic acid and dihydrolipoic acid. Implications for the problem of differential effects of lipoic acid in vitro and in vivo
    Authors:
    Anna Bilska-Wilkosz, Magdalena Górny, Magdalena Dudek, Leszek Nowiński, Marek Bednarski, Małgorzata Iciek, Danuta Kowalczyk-Pachel, Maria Sokołowksa-Jeżewicz, Barbara Filipek, Lidia Włodek
    Academic press:
    Acta Poloniae Pharmaceutica. Drug Research (rok: 2016, tom: 73, strony: 1531-1538), Wydawca: Polish Pharmaceutical Society. Warszawa
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Inactivation of aldehyde dehydrogenase by nitroglycerin in the presence and absence of lipoic acid and dihydrolipoic acid. Implications for the problem of differential effects of lipoic acid in vitro and in vivo
    Authors:
    Anna Bilska-Wilkosz, Magdalena Górny, Magdalena Dudek, Leszek Nowiński, Marek Bednarski, Małgorzata Iciek, Danuta Kowalczyk-Pachel, Maria Sokołowksa-Jeżewicz, Barbara Filipek, Lidia Włodek
    Academic press:
    Acta Poloniae Pharmaceutica. Drug Research (rok: 2016, tom: 73, strony: 1531-1538), Wydawca: Polish Pharmaceutical Society. Warszawa
    Status:
    Published
    DOI:
    link to the publication
  1. Cooperative kinetics of aldehyde dehydrogenase from Yeast
    Authors:
    Górny Magdalena, Luchter-Wasylewska Ewa, Włodek Lidia, Bilska-Wilkosz Anna
    Conference:
    21 th International Symposium "Molecular and Physiological Aspects of Regulatory Processes of the Organism" (rok: 2012, ), Wydawca: Henryk Lach, Małopolska Szkoła Wyższa im.Józefa Dietla w Krakowie, ul. W.Pola 4, 31-532 Kraków
    Data:
    konferencja 14-15 June
    Status:
    Published
  2. Aldehyde dehydrogenase. Do lipoic acid and nitroglycerin influence the activity of this protein in vivo and in vitro?
    Authors:
    Magdalena Górny, Anna Bilska-Wilkosz, Magdalena Dudek, Leszek Nowiński, Marek Bednarski, Małgorzata Iciek, Danuta Kowalczyk-Pachel, Maria Sokołowska-Jeżewicz, Barbara Filipek, Lidia Włodek
    Conference:
    IX Jakub K. Parnas Conference: Proteins from Birth to Death (rok: 2013, ), Wydawca: Joint Research Conference of the israel Institute for Advances Studies and the Israel Dcience Foundation
    Data:
    konferencja September 29 -October 2, 2013
    Status:
    Published
  3. Are lipoic acid and its reduced form, dihydrolipoic acid able to restore aldehyde dehydrogenase activity blocked by disulfiram in vitro?
    Authors:
    Danuta Kowalczyk-Pachel, Magdalena Górny, Anna Bilska-Wilkosz, Małgorzata Iciek, Maria Sokołowska-Jeżewicz, Lidia Włodek
    Conference:
    IX Jakub K. Parnas Conference: Proteins from Birth to Death (rok: 2013, ), Wydawca: Joint Research Conference of the israel Institute for Advances Studies and the Israel Dcience Foundation
    Data:
    konferencja September 29 -October 2, 2013
    Status:
    Published
  4. Thiol-based redox regulation of aldehyde dehydrogenase
    Authors:
    Małgorzata iciek, Magdalena Górny, Anna Bilska-Wilkosz, Danuta Kowalczyk-Pachel, Lidia Włodek
    Conference:
    14th International Congress on Amino Acids, Peptides and Proteins (rok: 2015, ), Wydawca: Springer Vienna
    Data:
    konferencja August 3-7
    Status:
    Published
    DOI:
    link to the publication
  5. Cooperative kinetics of aldehyde dehydrogenase from Yeast
    Authors:
    Górny Magdalena, Luchter-Wasylewska Ewa, Włodek Lidia, Bilska-Wilkosz Anna
    Conference:
    21 th International Symposium "Molecular and Physiological Aspects of Regulatory Processes of the Organism" (rok: 2012, ), Wydawca: Henryk Lach, Małopolska Szkoła Wyższa im.Józefa Dietla w Krakowie, ul. W.Pola 4, 31-532 Kraków
    Data:
    konferencja 14-15 June
    Status:
    Published
  6. Aldehyde dehydrogenase. Do lipoic acid and nitroglycerin influence the activity of this protein in vivo and in vitro?
    Authors:
    Magdalena Górny, Anna Bilska-Wilkosz, Magdalena Dudek, Leszek Nowiński, Marek Bednarski, Małgorzata Iciek, Danuta Kowalczyk-Pachel, Maria Sokołowska-Jeżewicz, Barbara Filipek, Lidia Włodek
    Conference:
    IX Jakub K. Parnas Conference: Proteins from Birth to Death (rok: 2013, ), Wydawca: Joint Research Conference of the israel Institute for Advances Studies and the Israel Dcience Foundation
    Data:
    konferencja September 29 -October 2, 2013
    Status:
    Published
  7. Are lipoic acid and its reduced form, dihydrolipoic acid able to restore aldehyde dehydrogenase activity blocked by disulfiram in vitro?
    Authors:
    Danuta Kowalczyk-Pachel, Magdalena Górny, Anna Bilska-Wilkosz, Małgorzata Iciek, Maria Sokołowska-Jeżewicz, Lidia Włodek
    Conference:
    IX Jakub K. Parnas Conference: Proteins from Birth to Death (rok: 2013, ), Wydawca: Joint Research Conference of the israel Institute for Advances Studies and the Israel Dcience Foundation
    Data:
    konferencja September 29 -October 2, 2013
    Status:
    Published
  8. The effect of lipoic acid and its reduced form on the activity of aldehyde dehydrogenase and glycerylaldehyde 3-phosphate dehydrogenase
    Authors:
    Anna Bilska-Wilkosz, Magdalena Górny, Małgorzata Iciek, Danuta Kowalczyk-Pachel, Lidia Włodek
    Conference:
    14th International Congress on Amino Acids, Peptides and Proteins (rok: 2015, ), Wydawca: Springer Vienna
    Data:
    konferencja August 3-7
    Status:
    Published
    DOI:
    link to the publication
  9. The effects of nitroglycerin on aldehyde dehydrogenase activity in vivo and in vitro. Implications for nitrate tolerance
    Authors:
    Anna Bilska-Wilkosz, Magdalena Dudek, Magdalena Górny, Leszek Nowiński, Marek Bednarski, Małgorzata Iciek, Danuta Kowalczyk-Pachel, Maria Sokołowska-Jeżewicz, Barbara Filipek, Lidia Włodek
    Conference:
    23th International Symposium "Molecular and Physiological Aspects of Regulatory Processes of the Organism (rok: 2013, ), Wydawca: Henryk Lach, Małopolska Szkoła Wyższa im.Józefa Dietla w Krakowie, ul. W.Pola 4, 31-532 Kraków
    Data:
    konferencja 14-15 June, 2013.
    Status:
    Published
  10. Lipoic acid, a well-known antioxidant, is able to restore aldehyde dehydrogenase activity blocked by nitroglycerin. Implications for nitrate tolerance
    Authors:
    Anna Bilska-Wilkosz, Magdalena Górny, Magdalena Dudek, Danuta Kowalczyk-Pachel, Małgorzata Iciek, Maria Sokołowska-Jeżewicz, Lidia Włodek
    Conference:
    Bio 2014 Congress: 1 st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 9 września-12 września
    Status:
    Published
    DOI:
    link to the publication
  11. Lipoic acid, a well-known antioxidant, is able to restore aldehyde dehydrogenase activity blocked by nitroglycerin. Implications for nitrate tolerance
    Authors:
    Anna Bilska-Wilkosz, Magdalena Górny, Magdalena Dudek, Danuta Kowalczyk-Pachel, Małgorzata Iciek, Maria Sokołowska-Jeżewicz, Lidia Włodek
    Conference:
    Bio 2014 Congress: 1 st Congress of the Polish Biochemistry, Cell Biology, Biophysics and Bioinformatics (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 9 września-12 września
    Status:
    Published
    DOI:
    link to the publication
  12. Dehydrogenaza aldehydowa: katalityczna aktywność w obecności liponianu i dihydroliponianu
    Authors:
    Magdalena Górny, Anna Bilska-Wilkosz, Lidia Włodek, Ewa Luchter-Wasylewska
    Conference:
    XLV Ogólnopolskie Kolokwium Katalityczne (rok: 2013, ), Wydawca: Instytut katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN, Kraków
    Data:
    konferencja 14-16 marca, 2013
    Status:
    Published
  13. The effects of nitroglycerin on aldehyde dehydrogenase activity in vivo and in vitro. Implications for nitrate tolerance
    Authors:
    Anna Bilska-Wilkosz, Magdalena Dudek, Magdalena Górny, Leszek Nowiński, Marek Bednarski, Małgorzata Iciek, Danuta Kowalczyk-Pachel, Maria Sokołowska-Jeżewicz, Barbara Filipek, Lidia Włodek
    Conference:
    23th International Symposium "Molecular and Physiological Aspects of Regulatory Processes of the Organism (rok: 2013, ), Wydawca: Henryk Lach, Małopolska Szkoła Wyższa im.Józefa Dietla w Krakowie, ul. W.Pola 4, 31-532 Kraków
    Data:
    konferencja 14-15 June, 2013.
    Status:
    Published
  14. Dehydrogenaza aldehydowa: katalityczna aktywność w obecności liponianu i dihydroliponianu
    Authors:
    Magdalena Górny, Anna Bilska-Wilkosz, Lidia Włodek, Ewa Luchter-Wasylewska
    Conference:
    XLV Ogólnopolskie Kolokwium Katalityczne (rok: 2013, ), Wydawca: Instytut katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN, Kraków
    Data:
    konferencja 14-16 marca, 2013
    Status:
    Published

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