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The role of endothelial barrier function in the pathogenesis of atherosclerosis and its modulation by the immune system

2011/01/D/NZ5/00925

Keywords

Descriptors

  • NZ5_3: Patogeneza chorób człowieka
  • NZ6_1: Odporność swoista i nieswoista

Panel

NZ5 – Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution

Uniwersytet Medyczny w Łodzi, Wydział Wojskowo-Lekarski, Klinika Chorób Wewnętrznych i Farmakologii Klinicznej

Voivodeship: łódzkie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Maciej Chałubiński

Number of co-investigators in the project: 7

Call

SONATA 1 – announced on 2011-03-15

Amount awarded
681 874 PLN
Project start date
2011-12-01
Project end date
2015-06-30
Project duration
43 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Electric Cell Substrate Impedance Sensing. Cost: 210 000 PLN
  2. Millicell-ERS (Electrical Resistance System) - Ohmvoltmeter. Cost: 5 000 PLN
  3. Wirówka z regulacją temperatury wirowania, z rotorem i adapterami. Cost: 25 000 PLN

Information in the final report

Publication in academic press/journals (3)

  1. The effect of interleukin-35 on the integrity, ICAM-1 expression and apoptosis of human aortic smooth muscle cells.

    Authors:
    Skowron W, Zemanek K, Wojdan K, Gorzelak P, Borowiec M, Broncel M, Chalubinski M.
    Academic press:
    Pharmacological Reports (year: 2014, volume: 67(2), pages: 376-81), Publisher: Polish Academy of Sciences
    Status:
    Published
    DOI:
    10.1016/j.pharep – link to the publication

  2. IL-33 and IL-4 impair barrier functions of human vascular endothelium via different mechanisms

    Authors:
    Chalubinski M, Wojdan K, Luczak E, Gorzelak P, Borowiec M, Gajewski A, Rudnicka K, Chmiela M, Broncel M.
    Academic press:
    Vascular Pharmacology (year: 2015, volume: 73, pages: 57-63), Publisher: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.vph.2015.07.012 – link to the publication

  3. The effect of 7-ketocholesterol and 25-hydroxycholesterol on the integrity of the human aortic endothelial and intestinal epithelial barriers

    Authors:
    Chalubinski M, Zemanek K, Skowron W, Wojdan K, Gorzelak P, Broncel M.
    Academic press:
    Inflammation Research (year: 2013, volume: 62, pages: 1015-1023), Publisher: Official Journal of: The International Association of Inflammation Societies + The European Histamine Research
    Status:
    Published
    DOI:
    10.1007/s00011-013-0660-x – link to the publication

Articles in post-conference publications (5)

  1. The effect of LPS and CpG on endothelial barrier functions and tolerogenic profile of dendritic cells in response to ApoB100

    Authors:
    Chalubinski M., Gebicka K., Wojdan K., Borowiec M., Mikolajczyk-Chmiela M., Broncel M.
    Conference:
    European Academy of Allergy and Clinical Immunology Congress 2014, Kopenchaga, Dania link: http://www.professionalabstracts.com/eaaci2014/planner/index.php?go=abstract&action=abstract_iplanner&print=1&lprID=1853&highlight=chalubinski&PSID=KLSSSPKURWEAJGKVVHKK (year: 2014, pages: 723), Publisher: European Academy of Allergy and Clinical Immunology
    Date:
    conference 7-11 czerwca
    Status:
    Published
    DOI:
    link to the publication

  2. Wpływ interleukiny-33 na integralność i funkcje immunomodulujące ludzkiego śródbłonka naczyniowego

    Authors:
    M. Chałubiński, E. Łuczak, K. Wojdan, P. Gorzelak, A. Gajewski, K. Rudnicka, M. Borowiec, M. Mikołajczyk-
    Conference:
    XIII Konferencja naukowo-Szkoleniaowa Alergia Astma Immunologia (year: 2014, pages: 116), Publisher: Mediton
    Date:
    conference 12-14 czerwca
    Status:
    Published

  3. Wpływ interleukiny-33 na integralność i funkcje immunomodulujące ludzkiego śródbłonka naczyniowego

    Authors:
    M. Chałubiński, E. Łuczak, K. Wojdan, P. Gorzelak, A. Gajewski, K. Rudnicka, M. Borowiec, M. Mikołajczyk-Chmiela, M. Broncel
    Conference:
    XVIII Międzynarodowy kongres Polskiego Towarzystwa Kardiologicznego (year: 2014, pages: 391-392), Publisher: Via Medica
    Date:
    conference 18-20 września
    Status:
    Published

  4. Te effect of CpG and oxydized cholesterol on the integrity and immunomodulatory properties of vascular endothelium

    Authors:
    M.Chałubiński, M. Kabacińska, W. Skowron, K. Zemanek, E. łuczak, A. Matusiak, M.Chmiela, M. Broncel
    Conference:
    The 3rd Workshop on Microbiology in Health and Environmental Protection MIKROBIOT 2013 (year: 2013, pages: 83), Publisher: zakład Wydawniczy Letter Quality
    Date:
    conference 17-20 września
    Status:
    Published

  5. Wpływ CpG ODN i oksydowanego cholesterolu na integralność i właściwości immunomodulujące śródbłonka naczyniowego

    Authors:
    M. Chałubiński, M. Kabacińska, W. Skowron, K. Zemanek, E. Łuczak, M. Chmiela, M. Broncel
    Conference:
    Alergia Astma Immunologia Kliniczna XII Konferencja Naukowo-Szkolenioawa (year: 2013, pages: 34), Publisher: Mediton
    Date:
    conference 13-15 czerwca
    Status:
    Published

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