Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Study on an enantioselective total synthesis of fungi-derived diterpenoids, (-)-guanacastepene A and (-)-heptamerone G, and on chemoenzymatic optical resolution of recemic gama-hydroxy-alfa,beta-unsatuared ketones

2011/01/B/ST5/00827

Keywords:

enantioselective total synthesis diterpenoids kinetic optical resolution dynamic kinetic resolution guanacastepene synthetic methods

Descriptors:

  • ST5_23:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Chemii Organicznej Polska Akademia Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jerzy Wicha 

Number of co-investigators in the project: 5

Call: OPUS 1 - announced on 2011-03-15

Amount awarded: 390 000 PLN

Project start date (Y-m-d): 2011-12-01

Project end date (Y-m-d): 2015-05-31

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Pompa próżniowa olejowa.
  2. Suszarka laboratoryjna.
  3. Wytrząsarka uniwersalna.

Information in the final report

  • Publication in academic press/journals (4)
  1. Studies towards dynamic kinetic resolution of 4-hydroxy-2-methylcyclopent-2-en-1-one and its E-O-trityl oxime
    Authors:
    Karol Michalak, Jerzy Wicha, Jacek Wójcik
    Academic press:
    Tetrahedron , Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  2. An Enantioselective Total Synthetic Approach to (+)-Heptemerone G and (+)-Guanacastepene A from 2-Furyl Methyl Carbinol.
    Authors:
    Michalak K. ; Wicha J.
    Academic press:
    Synlett (rok: 2013, tom: 2013, strony: 1387-1390), Wydawca: Thieme
    Status:
    Published
    DOI:
    10.1055/s-033-1338857 - link to the publication
  3. Chemoenzymatic Approach to Optically Active 4-Hydroxy-5-alkylcyclopent-2-en-1-one Derivatives: An Application of a Combined Circular Dichroism Spectroscopy and DFT Calculations to Assignment of Absolute Configuration
    Authors:
    J. Frelek, M. Karchier, D. Madej, K. Michalak, P. Różański, P., J. Wicha
    Academic press:
    Chirality (rok: 2014, tom: 26, strony: 300-306), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chir.22317 - link to the publication
  4. A convenient preparation of (S)-(-)-4-hydroxy-2- methylcyclopent-2-en-1-one and its application as a chiral synthetic equivalent of 2-methylcyclopent-2-en-1-one in the terpenoid synthesis.
    Authors:
    Michalak, K.; Wicha, J.,
    Academic press:
    Tetrahedron (rok: 2014, tom: 70, strony: 5073-5081), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tet.2014.06.006 - link to the publication

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