Projects funded by the NCN
Fluorinated analogues of marsanidine and 4-chloroindazim as potential PET radiotracers.
2011/01/B/NZ4/00520
Keywords:
imidazoline compounds radiotracer positron emission tomography,I2 imidazoline receptror alfa2-adrenoceptor
Descriptors:
- NZ4_16:
Panel:
NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology
Host institution :
Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej
woj. pomorskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 5
Call: OPUS 1 - announced on 2011-03-15
Amount awarded: 273 000 PLN
Project start date (Y-m-d): 2011-12-16
Project end date (Y-m-d): 2015-04-15
Project duration:: 40 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- reaktor mikrofalowy (38 000 PLN)
- rotacyjna wyparka próżniowa (14 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Fluorinated analogues of marsanidine, a highly alpha2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activitiesAuthors:Aleksandra Wasilewska, Franciszek Sączewski, Alan L. Hudson, Mehnaz Ferdousi, Mika Scheinin, Jonne M. Laurila, Apolonia Rybczyńska, Konrad Boblewski, Artur LehmannAcademic press:European Journal of Medicinal Chemistry (rok: 2014, tom: 87, strony: 386-397), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2014.09.083 - link to the publication
- The effect of 7-fluoro-marsanidine, a novel alpha2-adrenoceptor agonist, on extracellular noradrenaline in rat frontal cortex: a microdialysis studyAuthors:Mehnaz Ferdousi, Maggie Lalies, Aleksandra Wasilewska, Franciszek Sączewski, Alan HudsonAcademic press:Neuroscience Letters (rok: 2015, tom: 590, strony: 47-51), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.neulet.2015.01.062 - link to the publication