Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The role of the PERK-eIF2alpha pathway in the survival and cancerogenic potential of Bcr-Abl expressing cells - in vivo studies.

2011/01/N/NZ4/01707

Keywords:

Bcr-Abl CML UPR (Unfolded Protein Response) eIF2alpha PERK NSG mice

Descriptors:

  • NZ4_11: Metabolism

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Monika Kusio-Kobiałka 

Number of co-investigators in the project: 5

Call: PRELUDIUM 1 - announced on 2011-03-15

Amount awarded: 121 000 PLN

Project start date (Y-m-d): 2011-12-16

Project end date (Y-m-d): 2013-06-15

Project duration:: 18 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. w projekcie nie było funduszy przeznaczonych na zakup aparatury.

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (1)
  1. The PERK-eIF2alpha phosphorylation arm is a pro-survival pathway of BCR-ABL signaling and confers resistance to imatinib treatment in chronic myeloid leukemia cells
    Authors:
    Kusio-Kobiałka M., Podszywalow-Bartnicka P., Peidis P., Glodkowska-Mrowka E., Wolanin K., Leszak G., Seferynska I., Stoklosa T., Koromilas A., Piwocka K.
    Academic press:
    Cell Cycle (rok: 2012, tom: 0,472916666666667, strony: 4069-4078), Wydawca: Landes Bioscience
    Status:
    Published
    DOI:
    10.4161/cc.22387 - link to the publication
  1. PERK-eIF2α signaling pathway activated by BCR-ABL promotes resistance to imatinib and shows cancerogenic potential in vitro and in vivo
    Authors:
    Kusio-Kobialka M., Podszywalow- Bartnicka P., Peidis P., Stokłosa T., Glodkowska-Mrowka E., Seferynska I., Hoser G., Koromilas A.E., Piwocka K.
    Conference:
    47 Zjazd Polskiego Towarzystwa Biochemicznego, Poznań, 11 - 14 września 2012 r. (rok: 2012, ), Wydawca: The Journal of the Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 11 - 14 września 2012
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy