Projects funded by the NCN

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188 projects found matching your search criteria :

  1. Structural proteomics of mulberry silkworm hemolymph

    Call: OPUS 2 , Panel: NZ1

    Principal investigator: prof. Grzegorz Dariusz Bujacz

    Instytut Chemii Bioorganicznej PAN

  2. New 3,8-disubstituted purine nucleoside analogues as prospective application for research of structure and biological ac...

    Call: SONATA 3 , Panel: ST5

    Principal investigator: dr hab. Anna Pasternak

    Instytut Chemii Bioorganicznej PAN

  3. Development of chemical method for synthesis of biologically active triphosphates using thermolabile protecting groups

    Call: OPUS 4 , Panel: ST5

    Principal investigator: dr hab. Marcin Krzysztof Chmielewski

    Instytut Chemii Bioorganicznej PAN

  4. ABA transport in legumes - between drought stress responses and nitrogen fixation efficiency

    Call: HARMONIA 5 , Panel: NZ3

    Principal investigator: dr hab. Michał Jasiński

    Instytut Chemii Bioorganicznej PAN

  5. The use of genetic tools in experimental therapy of polyglutamine diseases.

    Call: SONATA BIS 5 , Panel: NZ2

    Principal investigator: dr hab. Marta Olejniczak

    Instytut Chemii Bioorganicznej PAN

  6. In vivo and in vitro structure of influenza virus RNA. The structural determinants behind the inhibition of influenza vi...

    Call: OPUS 10 , Panel: NZ1

    Principal investigator: prof. Elżbieta Kierzek

    Instytut Chemii Bioorganicznej PAN

  7. Role of microRNAs in regulation iron metabolism in Friedreich's ataxia

    Call: OPUS 10 , Panel: NZ1

    Principal investigator: dr hab. Marek Napierała

    Instytut Chemii Bioorganicznej PAN

  8. Bifunctional antisense oligonucleotides - optimization of alternative splicing regulation in cancer cell lines

    Call: SONATA 11 , Panel: NZ5

    Principal investigator: dr Jolanta Agnieszka Lisowiec-Wąchnicka

    Instytut Chemii Bioorganicznej PAN

  9. Ekspression of circular RNA in myotonic dystrophy type 1 - implications to pathogenesis

    Call: PRELUDIUM 11 , Panel: NZ5

    Principal investigator: dr Karol Czubak

    Instytut Chemii Bioorganicznej PAN

  10. Designing a new method for direct identification and absolute quantification of premature transcription termination even...

    Call: PRELUDIUM 12 , Panel: NZ1

    Principal investigator: dr Piotr Jan Machtel

    Instytut Chemii Bioorganicznej PAN

  11. Cotranscriptional folding of influenza virus RNA in MDCK cells in presence of antisense oligonucleotides. A new method f...

    Call: OPUS 13 , Panel: NZ1

    Principal investigator: prof. Ryszard Kierzek

    Instytut Chemii Bioorganicznej PAN

  12. Identification of biomolecules released by colorectal cancer cells and detected in serum or/and exosomes

    Call: SONATA 13 , Panel: NZ2

    Principal investigator: dr hab. Anna Wojakowska

    Instytut Chemii Bioorganicznej PAN

  13. Contribution of gene copy number polymorphism to natural variation in response of Arabidopsis thaliana ecotypes to bioti...

    Call: SONATA 13 , Panel: NZ2

    Principal investigator: dr hab. Agnieszka Jowita Żmieńko

    Instytut Chemii Bioorganicznej PAN

  14. Mechanisms of human gene expression regulation by uridilation

    Call: SONATA 13 , Panel: NZ1

    Principal investigator: dr hab. Zbigniew Stanisław Warkocki

    Instytut Chemii Bioorganicznej PAN

  15. Changes in the ribosomal protein composition and in the ribosome-associated small noncoding RNAs in Saccharomyces cerevi...

    Call: OPUS 14 , Panel: NZ1

    Principal investigator: dr hab. Kamilla Grzywacz

    Instytut Chemii Bioorganicznej PAN

  16. The use of artificial miRNAs in the therapy of Huntington's Disease

    Call: PRELUDIUM 20 , Panel: NZ1

    Principal investigator: dr Anna Kotowska-Zimmer

    Instytut Chemii Bioorganicznej PAN

  17. Investigation of DNA repair mechanisms in DRPLA model using CRISPR-Cas system

    Call: PRELUDIUM 20 , Panel: NZ2

    Principal investigator: dr Magdalena Dąbrowska

    Instytut Chemii Bioorganicznej PAN

  18. The puzzling structure of Grainyhead-like human transcription factors involved in tumor growth regulation

    Call: SONATINA 6 , Panel: NZ1

    Principal investigator: dr Maria Zofia Małecka

    Instytut Chemii Bioorganicznej PAN

  19. Crystallographic analysis of RNA-ligand complexes. Towards rational design oflead compounds for development of therapies...

    Call: OPUS 23 , Panel: NZ7

    Principal investigator: dr hab. Agnieszka Ludmiła Kiliszek

    Instytut Chemii Bioorganicznej PAN

  20. Description of the key mechanisms of coordination and prioritization of barley's response to simultaneous biotic and abi...

    Call: OPUS 23 , Panel: NZ9

    Principal investigator: dr Anna Barbara Piasecka

    Instytut Chemii Bioorganicznej PAN

  21. Microscopic identification of proteins involved in DNA repair of CAG repeats regions

    Call: PRELUDIUM 21 , Panel: NZ3

    Principal investigator: Mateusz Przemysław Nowaczyk

    Instytut Chemii Bioorganicznej PAN

  22. Molecular Mechanisms of Dietary Intervention on Neurodegeneration

    Call: JPND Call 2022 , Panel: NZ2

    Principal investigator: dr hab. Maciej Figiel

    Instytut Chemii Bioorganicznej PAN

  23. Functional characterization of ABCG transporters present in Medicago truncatula seeds

    Call: OPUS 24 , Panel: NZ9

    Principal investigator: prof. Michał Jasiński

    Instytut Chemii Bioorganicznej PAN

  24. Design and Development of Serine Hydroxymethyltransferase-2 (SHMT2) Inhibitors Blocking Tumor Growth

    Call: SONATA BIS 13 , Panel: NZ7

    Principal investigator: dr hab. Miłosz Ruszkowski

    Instytut Chemii Bioorganicznej PAN

  25. Unravelling the conservation of crossover hotspots and regulation of meiotic recombination at the pericentromeres

    Call: SONATINA 8 , Panel: NZ2

    Principal investigator: dr Maja Magdalena Szymańska-Lejman

    Instytut Chemii Bioorganicznej PAN

  26. Molecular basis of the function of WRKY transcription factors as pivotal regulators of plant responses to stress

    Call: OPUS 27 , Panel: NZ9

    Principal investigator: dr Marta Grzechowiak

    Instytut Chemii Bioorganicznej PAN

  27. Pioneering structural and functional studies of miRNA G-quadruplexes

    Call: SONATINA 2 , Panel: NZ1

    Principal investigator: dr Agnieszka Belter

    Instytut Chemii Bioorganicznej PAN

  28. Inhibition of S-adenosyl-L-homocysteine hydrolase from Pseudomonas aeruginosa by targeting the enzyme dynamics

    Call: SONATA BIS 8 , Panel: NZ1

    Principal investigator: dr hab. Krzysztof Brzeziński

    Instytut Chemii Bioorganicznej PAN

  29. Thermodynamic parameters and rules towards the determination of RNA folding in in vivo-like conditions. RNA folding pred...

    Call: OPUS 17 , Panel: ST4

    Principal investigator: prof. Ryszard Kierzek

    Instytut Chemii Bioorganicznej PAN

  30. Arc as a neuronal Gag. Exploring the viral properties and functions of a master regulator of synaptic plasticity.

    Call: PRELUDIUM 18 , Panel: NZ1

    Principal investigator: dr Julita Gumna

    Instytut Chemii Bioorganicznej PAN

  31. Long noncoding RNA - new aim of anti-influenza therapy

    Call: SONATA 16 , Panel: NZ6

    Principal investigator: dr Marta Soszyńska-Jóźwiak

    Instytut Chemii Bioorganicznej PAN

  32. Anti-cancer strategy based on the induced G-quadruplex formation. Structural and biological properties of ligand-RNA/mRN...

    Call: SONATA 16 , Panel: ST4

    Principal investigator: dr Dorota Gudanis-Sobocińska

    Instytut Chemii Bioorganicznej PAN

  33. Cell-based high-throughput screening for small-molecule compounds diminishing molecular markers of pathogenesis in myoto...

    Call: OPUS 20 , Panel: NZ3

    Principal investigator: dr hab. Marzena Wojciechowska

    Instytut Chemii Bioorganicznej PAN

  34. Identification of cancer-driver mutations in non-coding parts of protein-coding genes and long non-coding RNA genes

    Call: OPUS 20 , Panel: NZ5

    Principal investigator: prof. Piotr Kozłowski

    Instytut Chemii Bioorganicznej PAN

  35. Elucidation of the mechanisms that induce copy number polymorphism of large genome fragments and of the relations betwee...

    Call: OPUS 7 , Panel: NZ2

    Principal investigator: prof. Marek Marian Figlerowicz

    Instytut Chemii Bioorganicznej PAN

  36. Understanding the mechanism of action for small molecule kinase inhibitors in alleviating myotonic dystrophy type 1 (DM1...

    Call: OPUS 7 , Panel: NZ5

    Principal investigator: dr hab. Marzena Wojciechowska

    Instytut Chemii Bioorganicznej PAN

  37. Structural studies of proteins crucial for tick-mammal-pathogen interactions.

    Call: OPUS 9 , Panel: NZ1

    Principal investigator: prof. Mariusz Jaskólski

    Instytut Chemii Bioorganicznej PAN

  38. The complex nature of multidomain proteins: the unmasked activity of human Dicer ribonuclease – expect the unexpected

    Call: OPUS 28 , Panel: NZ2

    Principal investigator: dr hab. Anna Maria Kurzyńska-Kokorniak

    Instytut Chemii Bioorganicznej PAN

  39. Thrombotic Mechanisms in Human Cystathionine β-Synthase Deficiency

    Call: OPUS 1 , Panel: NZ1

    Principal investigator: prof. Hieronim Jakubowski

    Instytut Chemii Bioorganicznej PAN

  40. Aryl nucleoside phosphoroamidates - a new generation of anti-HIV pronucleotides.

    Call: OPUS 1 , Panel: ST5

    Principal investigator: prof. Jacek Antoni Stawiński

    Instytut Chemii Bioorganicznej PAN

  41. A new gereration of anticancer pronucleotides

    Call: OPUS 1 , Panel: NZ4

    Principal investigator: prof. Jacek Antoni Stawiński

    Instytut Chemii Bioorganicznej PAN

  42. New approaches towards modulating selective and functional activities of antisense oligonucleotides

    Call: OPUS 2 , Panel: ST5

    Principal investigator: prof. Ryszard Kierzek

    Instytut Chemii Bioorganicznej PAN

  43. Establishment of a novel scientific workshop enabling complex analysis of RNA degradome - elaboration of innovative meth...

    Call: SONATA 3 , Panel: NZ2

    Principal investigator: dr Paulina Maria Jackowiak

    Instytut Chemii Bioorganicznej PAN

  44. Structure - activity relationship studies of new flavonoids derivatives as the inhibitors of the bacterial tyrosyl-tRNA ...

    Call: PRELUDIUM 3 , Panel: NZ7

    Principal investigator: dr Mirosława Anna Skupińska

    Instytut Chemii Bioorganicznej PAN

  45. Study of the capabilities and limits of the use of Petri nets for modeling and analysis of complex biological systems on...

    Call: OPUS 4 , Panel: ST6

    Principal investigator: prof. Piotr Formanowicz

    Instytut Chemii Bioorganicznej PAN

  46. Plant secondary metabolites controlling microbial colonizers.

    Call: SONATA BIS 2 , Panel: NZ2

    Principal investigator: dr hab. Paweł Bednarek

    Instytut Chemii Bioorganicznej PAN

  47. Structure defined oligonucleotides for revealing fundamental insights into structure and function of RNAs

    Call: MAESTRO 4 , Panel: ST5

    Principal investigator: prof. Ryszard Kierzek

    Instytut Chemii Bioorganicznej PAN

  48. Ribozymes as a new tool for mitochondrial genome research

    Call: OPUS 5 , Panel: NZ1

    Principal investigator: prof. Jan Barciszewski

    Instytut Chemii Bioorganicznej PAN

  49. Thermodynamic insights into design of functionally optimized modified siRNAs and their experimental verification.

    Call: SONATA BIS 3 , Panel: NZ1

    Principal investigator: dr hab. Anna Pasternak

    Instytut Chemii Bioorganicznej PAN

  50. Essential features of miRNA precursors required for release of homogenous siRNAs from shRNA-miR vectors.

    Call: PRELUDIUM 6 , Panel: NZ1

    Principal investigator: dr Paulina Małgorzata Gałka-Marciniak

    Instytut Chemii Bioorganicznej PAN

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