Projects funded by the NCN


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49 projects found matching your search criteria :

  1. In search of biochemical, mechanical and functional fingerprints of oxidative stress in RBCs

    Call: OPUS 12 , Panel: ST4

    Principal investigator: dr Katarzyna Marzec

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  2. Towards novel mechanisms of endothelial dysfunction in E3L.CETP mice displaying hyperlipidaemia with human-like lipoprot...

    Call: OPUS 15 , Panel: NZ7

    Principal investigator: prof. Stefan Chłopicki

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  3. Role of angiotensin 1-12 and ACE-independent generation of Angiotensin II in peripheral endothelial dysfunction in heart...

    Call: PRELUDIUM 15 , Panel: NZ4

    Principal investigator: Tasnim Mohaissen

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  4. Breast cancer metastasis-induced endothelial-mesenchymal transition alongside ageing; implications for therapy

    Call: OPUS 21 , Panel: NZ5

    Principal investigator: dr Marta Smęda

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  5. PDMS-based specially designed microfluidic channel lined with primary endothelial cells: a novel tool for experimental p...

    Call: PRELUDIUM 20 , Panel: NZ7

    Principal investigator: Stefano Rocchetti

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  6. Multimodal approach for a comprehensive assessment of (dys)functional endothelial phenotype in isolated blood vessels

    Call: SONATA 17 , Panel: ST4

    Principal investigator: dr Marta Pacia

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  7. In the search of specific oxylipin fingerprint reflecting the development of endothelial dysfunction with the use of non...

    Call: SONATA 17 , Panel: NZ5

    Principal investigator: dr Agnieszka Kij

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  8. The Role of the Mitochondrial Unfolded Protein Response (UPRmt) in Endothelial Function: a Possible Novel Target for the...

    Call: PRELUDIUM 22 , Panel: NZ7

    Principal investigator: Sylwester Mosiołek

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  9. Raman spectroscopy in in studies on uptake of molecules by liver sinusoidal endothelial cells in vitro

    Call: PRELUDIUM 14 , Panel: ST4

    Principal investigator: dr Ewelina Matuszyk

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  10. Studies on antiplatelet and antithrombotic activity of CO-relasing molecules (CO-RM)

    Call: HARMONIA 4 , Panel: NZ7

    Principal investigator: prof. Stefan Chłopicki

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  11. Vibrational spectroscopy in analysis of biochemical status of blood that mirrors vascular wall pathology in animals with...

    Call: PRELUDIUM 5 , Panel: NZ4

    Principal investigator: Emilia Staniszewska-Ślęzak

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  12. Pharmacokinetic profiling to understand differences in biological activity of two novel liver-selective NO-releasing com...

    Call: PRELUDIUM 6 , Panel: NZ7

    Principal investigator: dr Kamil Kuś

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  13. Development of EPR oximetry methodology for evaluation of endothelial action of drugs

    Call: SONATA 3 , Panel: NZ7

    Principal investigator: dr Patrycja Kaczara

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  14. Effects of tyrosine kinase inhibitors on Syk pathway in eNOS-based platelet subpopulations and on endothelial barrier in...

    Call: POLONEZ BIS 3 , Panel: NZ7

    Principal investigator: dr hab. Aneta Radziwon-Balicka

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  15. Impairment of coronary microcirculation in a mouse model of a heart failure

    Call: SONATA 16 , Panel: NZ7

    Principal investigator: dr Grzegorz Kwiatkowski

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  16. The role of lactate dehydrogenase A in development of endothelial dysfunction in murine model of heart failure

    Call: PRELUDIUM 20 , Panel: NZ5

    Principal investigator: Agnieszka Karaś

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  17. In search of antiplatelet mechamism of CORMs (CO-releasing molecules): significance of kinetic of CO release, antiadhesi...

    Call: PRELUDIUM 11 , Panel: NZ7

    Principal investigator: Barbara Sitek

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  18. Towards experimental pharmacology of endothelium in vivo based on multiparameter method of the assessment of vascular en...

    Call: PRELUDIUM 12 , Panel: NZ5

    Principal investigator: Anna Bar

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  19. Endothelial inflammation studied in situ within functional blood vessels using Raman imaging, atomic force microscopy an...

    Call: SONATINA 1 , Panel: ST4

    Principal investigator: dr Marta Pacia

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  20. Badania kompleksów wybranych hemoprotein i ich przemian w układach biologicznych metodami spektroskopii molekularnej

    Call: ETIUDA 5 , Panel: ST4

    Principal investigator: Jakub Dybaś

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  21. Normalization of energy metabolism as a way to develop innovative antithrombotic therapies

    Call: OPUS 21 , Panel: NZ7

    Principal investigator: dr Patrycja Kaczara

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  22. Structural studies and chemical imaging of vitamins A, E and their metabolites in healthy and pathologically altered ani...

    Call: SONATA 4 , Panel: ST4

    Principal investigator: dr Katarzyna Marzec

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  23. Comparative evaluation of effects of tyrosine kinase inhibitors (TKIs) on endothelial function in vivo in mice

    Call: PRELUDIUM 17 , Panel: NZ5

    Principal investigator: Brygida Marczyk

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  24. To catch lifestyle diseases red-handed - in vivo Raman spectroscopy

    Call: OPUS 9 , Panel: ST4

    Principal investigator: dr hab. Agnieszka Kaczor

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  25. Aptamers in the study of thrombotic mechanisms dependent on platelet and erythrocyte functions by microfluidic devices.

    Call: ETIUDA 8 , Panel: NZ5

    Principal investigator: Katarzyna Derszniak

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  26. Aptamer-based biosensor for simultaneous detection of thrombin and von Willebrand factor in plasma.

    Call: PRELUDIUM 11 , Panel: NZ5

    Principal investigator: Katarzyna Derszniak

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  27. The role of reactive oxygen species (ROS) generated during a maximal exercise by endothelial NOX2 i NOX4 in the regulati...

    Call: PRELUDIUM 13 , Panel: NZ4

    Principal investigator: dr Kamil Przyborowski

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  28. Spektroskopia ramanowska w badaniu rozwoju niealkoholowego stłuszczenia wątroby z wykorzystaniem izolowanych komórek wąt...

    Call: ETIUDA 6 , Panel: ST4

    Principal investigator: dr Ewelina Matuszyk

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  29. LDL-mimetic liposomal contrast agent for MRI-based detection of increased endothelial permeability in the early phase of...

    Call: OPUS 20 , Panel: NZ5

    Principal investigator: dr Anna Bar

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  30. Metabolic reprogramming in age-dependent endothelial dysfunction and vascular stiffness; novel mechanism of 'inflamm-age...

    Call: MAESTRO 13 , Panel: NZ4

    Principal investigator: prof. Stefan Chłopicki

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  31. Cross-talk between endothelium and perivascular adipose tissue upon inflammation: high-resolution imaging of adipocytes ...

    Call: PRELUDIUM 22 , Panel: ST4

    Principal investigator: Ewa Stanek

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  32. Study of the influence of the drug physicochemical properties on its endothelial distribution and binding ability to pla...

    Call: PRELUDIUM 7 , Panel: NZ7

    Principal investigator: Anna Gonciarz-Dytman

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  33. The anti-inflammatory effect of vitamin K - Mechanism of action

    Call: PRELUDIUM 16 , Panel: NZ7

    Principal investigator: Anna Kierońska-Rudek

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  34. Function and phenotype of liver sinusoidal endothelial cells (LSECs) and their role in liver dysfunction development in ...

    Call: PRELUDIUM 18 , Panel: NZ5

    Principal investigator: Kamila Wojnar-Lasoń

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  35. Novel strategies for pharmacological modulation of platelet-derived microparticles - effects on endothelium

    Call: PRELUDIUM 19 , Panel: NZ5

    Principal investigator: Agnieszka Pełesz

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  36. Spectroscopic and microscopic techniques in nano-probing, modeling and recognition of interactions between erythrocytes ...

    Call: SONATA BIS 10 , Panel: ST4

    Principal investigator: dr hab. Katarzyna Marzec

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  37. Resonance Raman spectroscopy studies of the in vitro and ex vivo haemoglobin adducts with gasotransmitters in biological...

    Call: PRELUDIUM 12 , Panel: ST4

    Principal investigator: Jakub Dybaś

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  38. Small scale, great significance: Raman spectroscopy, 3D imaging, atomic force microscopy and immunohistochemical stainin...

    Call: PRELUDIUM 4 , Panel: ST4

    Principal investigator: Marta Pacia

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  39. Label-free imaging of subcelluar structures of endotelium using Confocal Raman Spectroscopy supported by FT-IR Spectrosc...

    Call: PRELUDIUM 5 , Panel: ST4

    Principal investigator: dr Katarzyna Majzner

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  40. From Symptoms to Treatment: a comprehensive characteristic of the evolution of pathological changes in an experimental m...

    Call: PRELUDIUM 5 , Panel: NZ7

    Principal investigator: Kamila Kochan

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  41. Perivascular adipose tissue versus gut microbiota: Raman imaging study

    Call: PRELUDIUM 20 , Panel: ST4

    Principal investigator: Zuzanna Majka

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  42. In search of the unexplored aspects of ferric heme protein-dependent regulationof nitric oxide signaling in the erythroc...

    Call: OPUS 21 , Panel: NZ3

    Principal investigator: dr Jakub Dybaś

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  43. Inhibition of protein disulfide isomerases as a strategy for reduction of prothrombotic state in atherosclerosis; therap...

    Call: SONATA 17 , Panel: NZ7

    Principal investigator: dr Kamil Przyborowski

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  44. Glycocalyx damage - the first stage of pathomechanism of endothelial dysfunction; measurements using capillary electroph...

    Call: PRELUDIUM 16 , Panel: NZ7

    Principal investigator: dr Karolina Matyjaszczyk-Gwarda

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  45. Studies on biologically relevant systems in conditions of resonance Raman optical activity

    Call: PRELUDIUM 17 , Panel: ST4

    Principal investigator: Ewa Machalska

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  46. CPL and RROA probes in the study of protein structure - induction of chirality and new methods of amplifying the chiropt...

    Call: OPUS 18 , Panel: ST4

    Principal investigator: dr Grzegorz Zając

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  47. In search of spectroscopic markers of autophagy based on pharmacologically induced phospholipidosis in endothelial cells

    Call: PRELUDIUM 18 , Panel: ST4

    Principal investigator: Ewelina Bik

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  48. Bioanalitycal and pharmacological studies on the compensatory mechanism dependent on MNA/COX-2/PGI2 pathway in NO-defici...

    Call: PRELUDIUM 9 , Panel: NZ7

    Principal investigator: Agnieszka Kij

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

  49. Description of platelets role in metastasis and evaluation of anti-platelet treatment efficacy in mice model of metastat...

    Call: PRELUDIUM 8 , Panel: NZ7

    Principal investigator: Elżbieta Buczek

    Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)