Dissecting the mechanisms of proteolytic cross-talk underlying pyroptosis, a programmed inflammatory cell death.
2018/29/B/NZ1/02249
Keywords
Descriptors
- NZ3_3: Apoptoza
- ST5_16: Chemia biologiczna
- NZ1_2: Biochemia
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Politechnika Wrocławska
Voivodeship: dolnośląskie
Principal investigator (from the host institution)
Number of co-investigators in the project: 4
Call
OPUS 15 – announced on 2018-03-15
- Amount awarded
- 1 280 000 PLN
- Project start date
- 2019-02-01
- Project end date
- 2022-07-31
- Project duration
- 42 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (5)
-
Diagnostic and therapeutic potential of protease inhibition
- Authors:
- Ćwilichowska N, Świderska KW, Dobrzyń A, Drąg M, PorębaM
- Academic press:
- Molecular Aspects of Medicine (year: 2022, volume: 88, pages: 101144), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.mam.2022.101144 – link to the publication
-
Resurrection of an ancient inflammatory locus reveals switch to caspase-1 specificity on a caspase-4 scaffold
- Authors:
- Bibo-Verdugo B, Jogleker I, Giridhar M, Ramirez, ML, Snipas SJ, Clark AC, Poreba M, Salvesen GS
- Academic press:
- Journal of Biological Chemistry (year: 2022, volume: 298, pages: 101931), Publisher: Elsevier
- Status:
- Published
- DOI:
- 10.1016/j.jbc.2022.101931 – link to the publication
-
Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells
- Authors:
- Groborz K, Gonzalez Ramirez ML, Snipas SJ, Salvesen GS, Drag M, Poreba M
- Academic press:
- Cell Death and Differentiation (year: 2019, volume: 27, pages: 451-465), Publisher: Springer Nature
- Status:
- Published
- DOI:
- 10.1038/s41418-019-0364-z – link to the publication
-
Recent advances in the development of legumain-selective chemical probes and peptide prodrugs
- Authors:
- Poreba M
- Academic press:
- Biological Chemistry (year: 2019, volume: 400, pages: 1529-1550), Publisher: De Gruyter
- Status:
- Published
- DOI:
- 10.1515/hsz-2019-0135 – link to the publication
-
Extended subsite profiling of the pyroptosis effector protein gasdermin D reveals a region recognized by inflammatory caspase-11
- Authors:
- Bibo-Verdugo B, Snipas SJ, Kolt S, Poreba M, Salvesen GS
- Academic press:
- Journal of Biological Chemistry (year: 2020, volume: 295, pages: 11292-11302), Publisher: American Society for Biochemistry and Molecular Biology
- Status:
- Published
- DOI:
- 10.1074/jbc.RA120.014259 – link to the publication