Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of ALKBH proteins in obesity and type 2 diabetes development using the pig model

2017/25/B/NZ4/02668

Keywords:

ALKBH obesity type 2 diabetes pig model IUGR FTO fat-high diet

Descriptors:

  • NZ4_11: Metabolism
  • NZ5_3: Pathogenesis of human diseases
  • NZ4_6: Endocrinology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biochemii i Biofizyki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Elżbieta Grzesiuk 

Number of co-investigators in the project: 6

Call: OPUS 13 - announced on 2017-03-15

Amount awarded: 1 240 920 PLN

Project start date (Y-m-d): 2018-01-19

Project end date (Y-m-d): 2022-01-18

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer stacjonarny (5 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  • Book publications / chapters in book publications (1)
  1. Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase
    Authors:
    Marcinkowski M, Pilžys T, Garbicz D, Piwowarski J, Mielecki D, Nowaczyk G, Taube M, Gielnik M, Kozak M, Winiewska-Szajewska M, Szołajska E, Dębski J, Maciejewska AM, Przygońska K, Ferenc K, Grzesiuk E, Poznański J
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 4512), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094512. - link to the publication
  2. Calmodulin as Ca2+-Dependent Interactor of FTO Dioxygenase
    Authors:
    Marcinkowski, Michał, Tomaš Pilžys, Damian Garbicz, Jan Piwowarski, Kaja Przygońska, Maria Winiewska-Szajewska, Karolina Ferenc, Oleksandr Skorobogatov, Jarosław Poznański, and Elżbieta Grzesiuk
    Academic press:
    International Journal of Molecular Sciences (rok: 2021, tom: 22, strony: 10869), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms221910869 - link to the publication
  3. IPK2019: Human and Arabidopsis alpha-ketoglutarate-dependent dioxygenase homolog proteins-New players in important regulatory processes
    Authors:
    Marcinkowski, Michal; Pilžys, Tomaš; Garbicz, Damian; Steciuk, Jaroslaw; Zugaj, Dorota; Mielecki, Damian; Sarnowski, Tomasz J.; Grzesiuk, Elżbieta
    Academic press:
    IUBMB Life (rok: 2020, tom: 72, strony: 1126-1144), Wydawca: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/iub.2276 - link to the publication
  4. ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy.
    Authors:
    Pilžys T, Marcinkowski M, Kukwa W, Garbicz D, Dylewska M, Ferenc K, Mieczkowski A, Kukwa A, Migacz E, Wołosz D, Mielecki D, Klungland A, Piwowarski J, Poznański J, Grzesiuk E.
    Academic press:
    Scientific Reports (rok: 2019, tom: 9, strony: 45307), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-49550-x - link to the publication
  5. Differences in Intestinal Barrier Development between Intrauterine Growth Restricted and Normal Birth Weight Piglets
    Authors:
    Olszewski J, Zabielski R, Skrzypek T, Matyba P, Wierzbicka M, Adamski A, Grzesiuk E, Sady M, Gajewski Z, Ferenc K
    Academic press:
    Animals (Basel). (rok: 2021, tom: 11(4), strony: 990), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ani11040990 - link to the publication
  6. Intracellular and tissue specific expression of FTO protein in pig: changes with age, energy intake and metabolic status
    Authors:
    Karolina Ferenc, Tomaš Pilžys, Damian Garbicz, Michał Marcinkowski, Oleksandr Skorobogatov, Małgorzata Dylewska, Zdzisław Gajewski, Elżbieta Grzesiuk, Romuald Zabielski
    Academic press:
    Scientific Reports (rok: 2020, tom: 10, strony: 45308), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-020-69856-5 - link to the publication
  1. cała książka
    Authors:
    wydanie wieloautorskie, edytorzy: Romuald Zabielski i Tomasz Skrzypek
    Book:
    Atlas of the Pig Gut Research and Techniques from Birth to Adulthood (rok: 2021, tom: 1, strony: 178), Wydawca: Academic Press
    Status:
    Published

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