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The role of ALKBH proteins in obesity and type 2 diabetes development using the pig model

2017/25/B/NZ4/02668

Keywords

Descriptors

  • NZ4_11: Metabolizm
  • NZ5_3: Patogeneza chorób człowieka
  • NZ4_6: Endokrynologia

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Instytut Biochemii i Biofizyki PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Elżbieta Grzesiuk

Number of co-investigators in the project: 6

Call

OPUS 13 – announced on 2017-03-15

Amount awarded
1 240 920 PLN
Project start date
2018-01-19
Project end date
2022-01-18
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Equipment purchased [PL]

  1. Komputer stacjonarny. Cost: 5 000 PLN

Information in the final report

Publication in academic press/journals (6)

  1. Calmodulin as Ca2+-Dependent Interactor of FTO Dioxygenase

    Authors:
    Marcinkowski, Michał, Tomaš Pilžys, Damian Garbicz, Jan Piwowarski, Kaja Przygońska, Maria Winiewska-Szajewska, Karolina Ferenc, Oleksandr Skorobogatov, Jarosław Poznański, and Elżbieta Grzesiuk
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 10869), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms221910869 – link to the publication

  2. Intracellular and tissue specific expression of FTO protein in pig: changes with age, energy intake and metabolic status

    Authors:
    Karolina Ferenc, Tomaš Pilžys, Damian Garbicz, Michał Marcinkowski, Oleksandr Skorobogatov, Małgorzata Dylewska, Zdzisław Gajewski, Elżbieta Grzesiuk, Romuald Zabielski
    Academic press:
    Scientific Reports (year: 2020, volume: 10, pages: 46039), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-020-69856-5 – link to the publication

  3. IPK2019: Human and Arabidopsis alpha-ketoglutarate-dependent dioxygenase homolog proteins-New players in important regulatory processes

    Authors:
    Marcinkowski, Michal; Pilžys, Tomaš; Garbicz, Damian; Steciuk, Jaroslaw; Zugaj, Dorota; Mielecki, Damian; Sarnowski, Tomasz J.; Grzesiuk, Elżbieta
    Academic press:
    IUBMB Life (year: 2020, volume: 72, pages: 1126-1144), Publisher: Wiley Online Library
    Status:
    Published
    DOI:
    10.1002/iub.2276 – link to the publication

  4. Differences in Intestinal Barrier Development between Intrauterine Growth Restricted and Normal Birth Weight Piglets

    Authors:
    Olszewski J, Zabielski R, Skrzypek T, Matyba P, Wierzbicka M, Adamski A, Grzesiuk E, Sady M, Gajewski Z, Ferenc K
    Academic press:
    Animals (Basel). (year: 2021, volume: 11(4), pages: 990), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ani11040990 – link to the publication

  5. Effect of Posttranslational Modifications on the Structure and Activity of FTO Demethylase

    Authors:
    Marcinkowski M, Pilžys T, Garbicz D, Piwowarski J, Mielecki D, Nowaczyk G, Taube M, Gielnik M, Kozak M, Winiewska-Szajewska M, Szołajska E, Dębski J, Maciejewska AM, Przygońska K, Ferenc K, Grzesiuk E, Poznański J
    Academic press:
    International Journal of Molecular Sciences (year: 2021, volume: 22, pages: 4512), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms22094512. – link to the publication

  6. ALKBH overexpression in head and neck cancer: potential target for novel anticancer therapy.

    Authors:
    Pilžys T, Marcinkowski M, Kukwa W, Garbicz D, Dylewska M, Ferenc K, Mieczkowski A, Kukwa A, Migacz E, Wołosz D, Mielecki D, Klungland A, Piwowarski J, Poznański J, Grzesiuk E.
    Academic press:
    Scientific Reports (year: 2019, volume: 9, pages: 46038), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-019-49550-x – link to the publication

Book publications / chapters in book publications (1)

  1. cała książka

    Authors:
    wydanie wieloautorskie, edytorzy: Romuald Zabielski i Tomasz Skrzypek
    Book:
    Atlas of the Pig Gut Research and Techniques from Birth to Adulthood (year: 2021, volume: 1, pages: 178), Publisher: Academic Press
    Status:
    Published

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