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The molecular mechanism of activity of alphaherpesvirus-encoded key immune evasion proteins

2014/14/E/NZ6/00164

Keywords

Descriptors

  • NZ6_5: Wirusologia
  • NZ1_1: Biologia molekularna
  • NZ1_10: Biologia drobnoustrojów

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

Voivodeship: pomorskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Andrea Lipińska

Number of co-investigators in the project: 9

Call

SONATA BIS 4 – announced on 2014-06-16

Amount awarded
1 870 760 PLN
Project start date
2015-05-05
Project end date
2021-01-04
Project duration
68 months (the same as in the proposal)
Project status
Project settled

Equipment purchased [PL]

  1. Nastołowy dwu-laserowy cytometr przepływowy z zestawem komputerowym. Cost: 250 000 PLN
  2. System do obrazowania i dokumentacji kwasów nukleinowych. Cost: 50 000 PLN
  3. Wirówka na duże objętości z chłodzeniem.
  4. Wirówka z chłodzeniem. Cost: 15 000 PLN
  5. Zestaw komputerowy dużej mocy obliczeniowej-serwer. Cost: 15 000 PLN

Information in the final report

Publication in academic press/journals (4)

  1. Investigation of the Effects of Primary Structure Modifications within the RRE Motif on the Conformation of Synthetic Bovine Herpesvirus 1‐Encoded UL49.5 Protein Fragments

    Authors:
    Karska N, Graul M, Sikorska E, Ślusarz MJ, Zhukov I, Kasprzykowski F, Kubiś A, Lipińska AD, Rodziewicz-Motowidło S.
    Academic press:
    Chemistry and Biodiversity (year: 2021, volume: 18(2), pages: e2000883), Publisher: Wiley-VHCA AG, Zurich, Switzerland
    Status:
    Published
    DOI:
    10.1002/cbdv.202000883 – link to the publication

  2. Fluorescent TAP as a platform for virus-induced degradation of the antigenic peptide transporter

    Authors:
    Wąchalska M, Graul M, Praest P, Luteijn RD, Babnis AW, Wiertz EJHJ, Bieńkowska-Szewczyk K, Lipińska AD
    Academic press:
    Cells (year: 2019, volume: 8, pages: E1590), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cells8121590 – link to the publication

  3. Structure determination of UL49.5 transmembrane protein from bovine herpesvirus 1 by NMR spectroscopy and molecular dynamics

    Authors:
    Karska N, Graul M, Sikorska E, Zhukov I, Ślusarz MJ, Kasprzykowski F, Lipińska AD, Rodziewicz-Motowidło S
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Biomembranes (year: 2019, volume: 1861(5), pages: 926-938), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2019.02.005 – link to the publication

  4. Transmembrane regions of bovine herpesvirus 1-encoded UL49.5 and glycoprotein M regulate complex maturation and ER-Golgi trafficking

    Authors:
    Graul M, Kisielnicka E, Rychłowski M, Verweij MC, Tobler K, Ackermann M, Wiertz EJHJ, Bieńkowska-Szewczyk K, Lipińska AD
    Academic press:
    Journal of General Virology (year: 2019, volume: 100(3), pages: 497-510), Publisher: Microbiology Society
    Status:
    Published
    DOI:
    10.1099/jgv.0.001224 – link to the publication

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Graphic design and implementation: Jakub Piotrowski