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Eutectic composition as an innovative approach for tackling the limited physical stability problem of amorphous pharmaceuticals

2023/51/B/ST5/02317

Keywords:

eutectic mixture glass co-amorphous system amorphous pharmaceuticals physical stability solubility enhancement

Descriptors:

  • NZ7_14:
  • ST3_13:
  • ST5_06:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

UNIWERSYTET ŚLĄSKI, Wydział Nauk Ścisłych i Technicznych

woj. śląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marian Wilhelm Paluch 

Number of co-investigators in the project: 5

Call: OPUS 26 - announced on 2023-09-18

Amount awarded: 1 999 946 PLN

Project start date (Y-m-d): 2024-08-01

Project end date (Y-m-d): 2028-07-31

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Eutectic Coamorphous System of Enzalutamide and Acetyl Maltose: A Strategy for Improved Physical Stability and Aqueous Solubility
    Authors:
    Julia Cichocka-Łokuciejewska, Justyna Knapik-Kowalczuk, Mateusz Dulski, Katarzyna Ewa Greber, Wiesław Sawicki, Marian Paluch
    Academic press:
    Mol. Pharmaceutics (rok: 2026, tom: jeszcze nie nadano, strony: jeszcze nie nadano), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.5c01164 - link to the publication
  2. High-Pressure Dielectric Spectroscopic Studies of Amorphous CBD: Investigating Molecular Dynamics and Physical Stability Under Manufacturing Conditions of the Pharmaceuticals
    Authors:
    Mariya Mathew, Justyna Knapik-Kowalczuk, Mateusz Dulski, Marian Paluch
    Academic press:
    Pharmaceutics (rok: 2025, tom: 17(3), 358, strony: 46039), Wydawca: mdpi
    Status:
    Published
    DOI:
    10.3390/pharmaceutics17030358 - link to the publication

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