Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Molecular biomechanics of the SARS-CoV-2 variants: The virus-host cell attachment and immune evasion

2022/45/B/NZ1/02519

Keywords:

biophysics molecular biomechanics virus-cell interaction coronavirus immune evasion single molecule force spectroscopy

Descriptors:

  • NZ1_003:
  • NZ2_008:
  • ST3_016:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Podstawowych Problemów Techniki Polskiej Akademii Nauk

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Adolfo Maximo Poma Bernaola 

Number of co-investigators in the project: 3

Call: OPUS 23 - announced on 2022-03-28

Amount awarded: 1 760 460 PLN

Project start date (Y-m-d): 2023-01-03

Project end date (Y-m-d): 2027-01-02

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. The GōMartini Approach: Revisiting the Concept of Contact Maps and the Modelling of Protein Complexes
    Authors:
    L.F. Cofas-Vargas, R.A. Moreira, S. Poblete, M. Chwastyk, A.B. Poma
    Academic press:
    Acta Physica Polonica A (rok: 2024, tom: 145, strony: 20), Wydawca: Institute of Physics of the Polish Academy of Science
    Status:
    Published
    DOI:
    10.12693/APhysPolA.145.S9 - link to the publication
  2. Single-Molecule Investigation of the Binding Interface Stability of SARS-CoV-2 Variants with ACE2
    Authors:
    Ray A, Minh T.T. M, Natividade R.d.S., Moreira R.A., Simpson J.D., Mohammed D., Koehler M., Petitjean S.J.L, Zhang Q., Bureau F., Gillet L., Poma A.B, Alsteens D.
    Academic press:
    ACS Nanoscience Au (rok: 2024, tom: 4, strony: 136-145), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acsnanoscienceau.3c00060 - link to the publication
  3. The GōMartini Approach: Revisiting the Concept of Contact Maps and the Modelling of Protein Complexes
    Authors:
    L.F. Cofas-Vargas, R.A. Moreira, S. Poblete, M. Chwastyk, A.B. Poma
    Academic press:
    Acta Physica Polonica A (rok: 2024, tom: 145, strony: 20), Wydawca: Institute of Physics of the Polish Academy of Science
    Status:
    Published
    DOI:
    10.12693/APhysPolA.145.S9 - link to the publication
  4. Nanomechanical footprint of SARS-CoV-2 variants in complex with a potent nanobody by molecular simulations
    Authors:
    Cofas-Vargas L.F.,Olivos-Ramirez G.E., Chwastyk M., Moreira R.A.M., Baker J.L., Marrink S.J., Poma A.B.
    Academic press:
    Nanoscale (rok: 2024, tom: 16, strony: 18824-18834), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D4NR02074J - link to the publication
  5. Conformational and stability analysis of SARS-CoV-2 spike protein variants by molecular simulation
    Authors:
    Olivos-Ramirez G.E., Cofas-Vargas L.F., ,Madl T., Poma A.B
    Academic press:
    Pathogens (rok: 2025, tom: 14, strony: 274), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pathogens14030274 - link to the publication

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