Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Highly-internalizing intrinsically fluorescent oligomeric cytotoxic conjugate targeting breast cancer cells overproducing HER2

2022/45/N/NZ1/00088

Keywords:

HER2 receptor clustering breast cancer endocytosis oligomerization oligomer fluorescence cytotoxic conjugate

Descriptors:

  • NZ1_002:
  • NZ1_001:
  • NZ1_009:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Wrocławski, Wydział Biotechnologii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Natalia Porębska 

Number of co-investigators in the project: 2

Call: PRELUDIUM 21 - announced on 2022-03-28

Amount awarded: 209 840 PLN

Project start date (Y-m-d): 2023-01-19

Project end date (Y-m-d): 2026-01-18

Project duration:: 36 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (7)
  1. Multivalent protein-drug conjugates – An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells
    Authors:
    Porębska, N., Ciura, K., Chorążewska, A., Zakrzewska, M., Otlewski, J., Opaliński, Ł.
    Academic press:
    Biotechnology Advances (rok: 2023, tom: 67, strony: 108213), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biotechadv.2023.108213 - link to the publication
  2. N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope
    Authors:
    Gregorczyk, P.#, Porebska, N.#, Żukowska, D., Chorążewska, A., Gędaj, A., Malinowska, A., Otlewski, J., Zakrzewska, M., Opaliński, Ł
    Academic press:
    Cell Communication and Signaling (rok: 2023, tom: 21, strony: 177), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-023-01203-3 - link to the publication
  3. Receptor clustering by a precise set of extracellular galectins initiates FGFR signaling
    Authors:
    Żukowska, D., Gędaj, A., Porębska, N., Poźniak, M., Krzyścik, M., Czyrek, A., Krowarsch D., Zakrzewska, M., Otlewski, J., Opaliński, Ł
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2023, tom: 80, strony: 113), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-023-04768-x - link to the publication
  4. Targeting HER2 and FGFR-positive cancer cells with a bispecific cytotoxic conjugate combining anti-HER2 Affibody and FGF2
    Authors:
    Krzyścik, M., Porębska, N., Opaliński, Ł., Otlewski, J
    Academic press:
    International Journal of Biological Macromolecules (rok: 2024, tom: 254(1), strony: 127657), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2023.127657 - link to the publication
  5. Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
    Authors:
    Gędaj, A., Żukowska, D., Porębska, N., Poźniak, M., Krzyścik, M., Czyrek, A., Krowarsch D., Zakrzewska, M., Otlewski, J., Opaliński, Ł.
    Academic press:
    Cell Communication and Signaling (rok: 2023, tom: 21, strony: 122), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-023-01144-x - link to the publication
  6. N-glycosylation acts as a switch for FGFR1 trafficking between the plasma membrane and nuclear envelope
    Authors:
    Gregorczyk, P.#, Porebska, N.#, Żukowska, D., Chorążewska, A., Gędaj, A., Malinowska, A., Otlewski, J., Zakrzewska, M., Opaliński, Ł
    Academic press:
    Cell Communication and Signaling (rok: 2023, tom: 21, strony: 177), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s12964-023-01203-3 - link to the publication
  7. Targeting HER2 and FGFR-positive cancer cells with a bispecific cytotoxic conjugate combining anti-HER2 Affibody and FGF2
    Authors:
    Krzyścik, M., Porębska, N., Opaliński, Ł., Otlewski, J
    Academic press:
    International Journal of Biological Macromolecules (rok: 2024, tom: 254(1), strony: 127657), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2023.127657 - link to the publication

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