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Information on the principal investigator and host institution

Information of the project and the call

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The novel view on circulating and hematopoietic stem cell-expressed complement in hematopoietic posttransplant recovery

2022/45/B/NZ6/00475

Keywords:

hematopoietic stem cells complement cascade Nlrp3 inflammasome bone marrow homing engraftment of hematopoietic stem cells hematopoietic transplantation

Descriptors:

  • NZ6_001:
  • NZ6_003:
  • NZ6_002:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Warszawski Uniwersytet Medyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Mariusz Zdzisław Ratajczak 

Number of co-investigators in the project: 5

Call: OPUS 23 - announced on 2022-03-28

Amount awarded: 2 674 240 PLN

Project start date (Y-m-d): 2023-02-15

Project end date (Y-m-d): 2027-02-14

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. Leukemogenesis occurs in a microenvironment enriched by extracellular microvesicles/exosomes: recent discoveries and questions to be answered.
    Authors:
    Ratajczak MZ, Ratajczak J.
    Academic press:
    Leukemia (rok: 2024, tom: 1, strony: 45664), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41375-024-02188-9 - link to the publication
  2. Mitochondria Express Functional Signaling Ligand-Binding Receptors that Regulate their Biological Responses - the Novel Role of Mitochondria as Stress-Response Sentinels.
    Authors:
    Brzezniakiewicz-Janus, K., Jarczak, J., Konopko, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2025, tom: 10,1007, strony: s12015-025), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-10847-2 - link to the publication
  3. Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity.
    Authors:
    Franczak, S., Ulrich, H., & Ratajczak, M. Z.
    Academic press:
    Purinergic signalling (rok: 2023, tom: 1, strony: 45664), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11302-023-09943-0 - link to the publication
  4. Complosome Regulates Hematopoiesis at the Mitochondria Level
    Authors:
    Konopko, A., Łukomska, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2025, tom: 10,1007, strony: s12015-025), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-10856-1 - link to the publication
  5. Hematopoietic stem cells on the crossroad between purinergic signaling and innate immunity.
    Authors:
    Franczak, S., Ulrich, H., & Ratajczak, M. Z.
    Academic press:
    Purinergic signalling (rok: 2023, tom: 1, strony: 45664), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11302-023-09943-0 - link to the publication
  6. The Different Responsiveness of C3- and C5-deficient Murine BM Cells to Oxidative Stress Explains Why C3 Deficiency, in Contrast to C5 Deficiency, Correlates with Better Pharmacological Mobilization and Engraftment of Hematopoietic Cells.
    Authors:
    Konopko, A., Łukomska, A., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (rok: 2024, tom: 21(1), strony: 59-67), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10792-6 - link to the publication
  7. Extracellular microvesicles/exosomes-magic bullets in horizontal transfer between cells of mitochondria and molecules regulating mitochondria activity.
    Authors:
    Ratajczak, M. Z., Thetchinamoorthy, K., Wierzbicka, D., Konopko, A., Ratajczak, J., & Kucia, M.
    Academic press:
    Stem cells (rok: 2025, tom: 43(3), strony: sxae086), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/stmcls/sxae086 - link to the publication
  8. Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner.
    Authors:
    Ratajczak MZ, Adamiak M, Abdelbaset-Ismail A, Bujko K, Thapa A, Chumak V, Franczak S, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M.
    Academic press:
    Leukemia (rok: 2023, tom: 6, strony: 1401-1405), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41375-023-01894-0 - link to the publication
  9. Intracellular complement (complosome) is expressed in hematopoietic stem/progenitor cells (HSPCs) and regulates cell trafficking, metabolism and proliferation in an intracrine Nlrp3 inflammasome-dependent manner.
    Authors:
    Ratajczak MZ, Adamiak M, Abdelbaset-Ismail A, Bujko K, Thapa A, Chumak V, Franczak S, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M.
    Academic press:
    Leukemia (rok: 2023, tom: 6, strony: 1401-1405), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41375-023-01894-0 - link to the publication

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