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Electrospun nanofiber-based nanoplatform for delivery of new nutraceutical derivatives to eliminate chemotherapy-induced senescent breast cancer cells

2021/43/B/NZ7/02129

Keywords

Descriptors

  • NZ7_014: Farmacja, farmakoterapia, farmakologia
  • NZ7_016: Inne zagadnienia pokrewne
  • NZ5_007: Leczenie chorób człowieka

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Uniwersytet Rzeszowski, Collegium Medicum

Voivodeship: podkarpackie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Maciej Antoni Wnuk

Number of co-investigators in the project: 10

Call

OPUS 22 – announced on 2021-09-15

Amount awarded
2 191 240 PLN
Project start date
2022-07-15
Project end date
2027-01-14
Project duration
54 months (the same as in the proposal)
Project status
Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (4)

  1. New Mitochondria-Targeted Fisetin Derivative Compromises Mitophagy and Limits Survival of Drug-Induced Senescent Breast Cancer Cells

    Authors:
    Rzeszutek I, Cybularczyk-Cecotka M, Deręgowska A, Stec P, Wnuk M, Kołodziej O, Kałafut J, Wawruszak A, Witkowski W, Litwinienko G, Lewińska A.
    Academic press:
    Journal of Medicinal Chemistry (year: 2024, volume: 67, 19,, pages: 17676–17689), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.jmedchem.4c01664 – link to the publication

  2. Mutation Status and Glucose Availability Affect the Response to Mitochondria-Targeted Quercetin Derivative in Breast Cancer Cells

    Authors:
    Przybylski P, Lewińska A, Rzeszutek I, Błoniarz D, Moskal A, Betlej G, Deręgowska A, Cybularczyk-Cecotka M, Szmatoła T, Litwinienko G, Wnuk M.
    Academic press:
    Cancers (Basel) (year: 2023, volume: 15(23), pages: 5614), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers15235614 – link to the publication

  3. Carbon-Coated Iron Oxide Nanoparticles Promote Reductive Stress-Mediated Cytotoxic Autophagy in Drug-Induced Senescent Breast Cancer Cells

    Authors:
    Lewińska A, Radoń A, Gil K, Błoniarz D, Ciuraszkiewicz A, Kubacki J, Kądziołka-Gaweł M, Łukowiec D, Gębara P, Krogul-Sobczak A, Piotrowski P, Fijałkowska O, Wybraniec S, Szmatoła T, Kolano-Burian A, Wnuk M.
    Academic press:
    ACS Applied Materials & Interfaces (year: 2024, volume: 16(12), pages: 15457-15478), Publisher: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acsami.3c17418 – link to the publication

  4. Electrospun fiber-based micro- and nano-system for delivery of high concentrated quercetin to cancer cells

    Authors:
    Hudecki A, Rzeszutek I, Lewińska A, Warski T, Baranowska-Korczyc A, Wojnarowska-Nowak R, Betlej G, Deręgowska A, Hudecki J, Łyko-Morawska D, Likus W, Moskal A, Krzemiński P, Cieślak M, Kęsik-Brodacka M, Kolano-Burian A, Wnuk M
    Academic press:
    Biomaterials Advances (Formerly known as Materials Science and Engineering: C) (year: 2023, volume: 153, pages: 213582), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bioadv.2023.213582 – link to the publication

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