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MOF-antidote": Novel detoxification materials based on metal organic-frameworks for drugs of abuse removal - synthesis, chemical characterization, toxicity and efficacy in in vivo and in vitro studies

2021/43/B/NZ7/00827

Keywords

Descriptors

  • NZ7_015: Toksykologia

Panel

NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution

Politechnika Krakowska im. Tadeusza Kościuszki

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Przemysław Jakub Jodłowski

Number of co-investigators in the project: 7

Call

OPUS 22 – announced on 2021-09-15

Amount awarded
1 884 560 PLN
Project start date
2022-09-01
Project end date
2025-08-31
Project duration
36 months (the same as in the proposal)
Project status
Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (7)

  1. Reviving the Fight against Opioid Overdoses: Unleashing the Power of Metal–Organic Frameworks for Morphine Removal

    Authors:
    K. Hyjek, K. Dymek, G. Kurowski, A. Boguszewska-Czubara, B. Budzyńska, J.A.R. Navarro, E. Borrego-Marin, W. Mrozek, J. Grymuza, A. Pajdak, W. Piskorz, P. Śliwa, A. Wielgosz, A. Stachniuk, E. Fornal, P.J. Jodłowski
    Academic press:
    ACS Applied Materials & Interfaces (year: 2025, volume: 17, pages: 67670−67689), Publisher: ACS
    Status:
    Published
    DOI:
    10.1021/acsami.5c19297 – link to the publication

  2. Metal-organic frameworks for efficient mephedrone detoxification or supervised withdrawal – synthesis, characterisation, and in vivo studies

    Authors:
    K. Hyjek, G. Kurowski, K. Dymek, A. Boguszewska-Czubara, B. Budzyńska, O. Wronikowska-Denysiuk, A. Gajda, W. Piskorz, P. Śliwa, M. Szumera, P. Jeleń, M. Sitarz, P.J. Jodłowski
    Academic press:
    Chemical Engineering Journal (year: 2024, volume: 479, pages: 147655 Contents), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cej.2023.147655 – link to the publication

  3. Synthesis, properties and prospective medical applications of metal-organic frameworks

    Authors:
    Kornelia Hyjek, Łukasz Kuterasiński, Witold Piskorz , Przemysław J. Jodłowski
    Academic press:
    Chemical and Process Engineering: New Frontiers (year: 2025, volume: 46(2), pages: e89), Publisher: Polska Akademia Nauk
    Status:
    Published
    DOI:
    10.24425/cpe.2025.153674 – link to the publication

  4. Crystal Clear: Metal–Organic Frameworks Pioneering the Path to Future Drug Detox

    Authors:
    Jodłowski, P. J.; Dymek, K.; Kurowski, G.; Hyjek, K.; Boguszewska-Czubara, A.; Budzyńska, B.; Mrozek, W.; Skoczylas, N.; Kuterasiński, Ł.; Piskorz, W.; Białoruski, M.; Jędrzejczyk, R. J.; Jeleń, P.; Sitarz, M.
    Academic press:
    ACS Applied Materials & Interfaces (year: 2024, volume: 16, pages: 29657-29671), Publisher: ACS
    Status:
    Published
    DOI:
    10.1021/acsami.4c02450 – link to the publication

  5. In vivo and in vitro studies of efficient mephedrone adsorption over zirconium-based metal-organic frameworks corroborated by DFT+D modeling

    Authors:
    P.J. Jodłowski, K. Dymek, G. Kurowski, K. Hyjek, A. Boguszewska-Czubara, B. Budzyńska, A. Pajdak, Ł. Kuterasiński, W. Piskorz, P. Jeleń, M. Sitarz
    Academic press:
    Microporous and Mesoporous Materials (year: 2023, volume: 359, pages: 112647), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.micromeso.2023.112647 – link to the publication

  6. Metal-organic frameworks for efficient drug adsorption and delivery

    Authors:
    K. Hyjek, P. Jodłowski
    Academic press:
    Scientiae Radices (year: 2023, volume: 2, pages: 118-189), Publisher: Radom Scientific Society
    Status:
    Published
    DOI:
    10.58332/scirad2023v2i2a03 – link to the publication

  7. From crystal phase mixture to pure metal-organic frameworks – Tuning pore and structure properties

    Authors:
    Jodłowski, P. J.; Kurowski, G.; Dymek, K.; Oszajca, M.; Piskorz, W.; Hyjek, K.; Wach, A.; Pajdak, A.; Mazur, M.; Rainer, D. N.; Wierzbicki, D.; Jeleń, P.; Sitarz
    Academic press:
    Ultrasonics Sonochemistry (year: 2023, volume: 95, pages: 106377), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ultsonch.2023.106377 – link to the publication

Book publications / chapters in book publications (1)

  1. A BRIEF OVERVIEW ON METAL-ORGANIC FRAMEWORK - SYNTHESIS, CHARACTERIZATION AND APPLICATION FOR MEDICINE PURPOSES

    Authors:
    Hyjek K, Jodłowski P. J.
    Book:
    Chemical and Process Engineering for Environment and Health, Current status in 2024 (year: 2024, volume: -, pages: 153-164), Publisher: Publishing House of Łukasiewicz - Institute for Sustainable Technologies
    Status:
    Published

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Graphic design and implementation: Jakub Piotrowski