Projects funded by the NCN

Information on the principal investigator and host institution

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Synthesis and structural/biophysical studies of model mRNA/mt-tRNA oligomers to evaluate the role of modified nucleosides (m5C, hm5C, f5C, ca5C, m1G) in translation and human diseases

2021/43/B/ST4/01570

Keywords:

mRNA/mt-tRNA modified nucleosides RNA oligomer synthesis modified cytidines modified guanosines RNA structure biomolecular RNA spectroscopy thermodynamic stability of RNAs

Descriptors:

  • ST4_008:
  • ST4_009:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Politechnika Łódzka

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Grażyna Bożena Leszczyńska 

Number of co-investigators in the project: 8

Call: OPUS 22 - announced on 2021-09-15

Amount awarded: 1 783 934 PLN

Project start date (Y-m-d): 2022-07-21

Project end date (Y-m-d): 2026-07-20

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Protection-free, two-step synthesis of C5-C functionalized pyrimidine nucleosides
    Authors:
    Podskoczyj Karolina, Kuszczynska Anna, Dziergowska Agnieszka, Leszczynska Grazyna
    Academic press:
    Current Protocols (rok: 2024, tom: 4, strony: e984), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1002/cpz1.984 - link to the publication
  2. Two-step conversion of uridine and cytidine to variously C5-C functionalized analogs,.
    Authors:
    Podskoczyj, K.; Kłos A.; Drewniak Sz.; Leszczyńska G.
    Academic press:
    Organic Biomolecular Chemistry (rok: 2023, tom: 21, strony: 2809-2815), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d3ob00161j - link to the publication
  3. Chemistry of installing epitranscriptomic 5-modified cytidines in RNA oligomers
    Authors:
    Kuszczynska Anna, Bors Milena, Podksoczyj Karolina, Leszczynska Grażyna
    Academic press:
    Organic Biomolecular Chemistry (rok: 2024, tom: 22, strony: 7271-7286.), Wydawca: Royal Society
    Status:
    Published
    DOI:
    10.1039/D4OB01098A - link to the publication
  4. Two-step conversion of uridine and cytidine to variously C5-C functionalized analogs,.
    Authors:
    Podskoczyj, K.; Kłos A.; Drewniak Sz.; Leszczyńska G.
    Academic press:
    Organic Biomolecular Chemistry (rok: 2023, tom: 21, strony: 2809-2815), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/d3ob00161j - link to the publication

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