Studies on anti-inflammatory properties of GPR18 ligands and their involvement in modulation of microglia phenotypes – a new target in therapy of neuroinflammation
2021/43/B/NZ7/01938
Keywords
Descriptors
- NZ7_004: Prewencja populacyjna
- NZ7_012: Prewencja chorób człowieka
- NZ3_006: Neurobiologia komórkowa
Panel
NZ7 – Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution
Uniwersytet Jagielloński, Collegium Medicum
Voivodeship: małopolskie
Principal investigator (from the host institution)
dr hab. Dorota Justyna Łażewska
Number of co-investigators in the project: 8
Call
OPUS 22 – announced on 2021-09-15
- Amount awarded
- 1 996 530 PLN
- Project start date
- 2022-07-18
- Project end date
- 2027-07-17
- Project duration
- 60 months (the same as in the proposal)
- Project status
- Pending project
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (3)
-
Uncovering the Power of GPR18 Signalling: How RvD2 and Other Ligands Could Have the Potential to Modulate and Resolve Inflammation in Various Health Disorders
- Authors:
- Honkisz-Orzechowska E, Łażewska D, Baran G, Kieć-Kononowicz K.
- Academic press:
- Molecules (year: 2024, volume: 29, pages: 1258), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/molecules29061258 – link to the publication
-
Potent, Selective Agonists for the Cannabinoid-like Orphan G Protein-Coupled Receptor GPR18: A Promising Drug Target for Cancer and Immunity
- Authors:
- Mahardhika AB, Załuski M, Schoeder CT, Boshta NM, Schabikowski J, Perri F, Łażewska D, Neumann A, Kremers S, Oneto A, Ressemann A, Latacz G, Namasivayam V, Kieć-Kononowicz K, Müller CE.
- Academic press:
- Journal of Medicinal Chemistry (year: 2024, volume: 67, pages: 9896-9926), Publisher: ACS Publication
- Status:
- Published
- DOI:
- 10.1021/acs.jmedchem.3c02423 – link to the publication
-
Novel GPR18 Ligands in Rodent Pharmacological Tests: Effects on Mood, Pain, and Eating Disorders
- Authors:
- Małgorzata Frankowska, Karolina Wydra, Agata Suder, Magdalena Zaniewska, Dawid Gawliński, Joanna Miszkiel, Anna Furgała-Wojas , Kinga Sałat , Małgorzata Filip, Christa E M, Katarzyna Kieć-Kononowicz, Magdalena Kotańska
- Academic press:
- International Journal of Molecular Sciences (year: 2023, volume: 24, pages: 9046), Publisher: MDPI
- Status:
- Published
- DOI:
- 10.3390/ijms24109046 – link to the publication