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Information of the project and the call

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Laser Emission of Thioflavin T and its analogues to uncover the early symptoms of neurodegenerative diseases.

2021/43/D/ST4/01741

Keywords:

Laser emission amplified spontaneous emission Tioflavin T beta amyloid alpha-synuclein neurodegeneration

Descriptors:

  • ST4_002:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Warszawski, Wydział Fizyki

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Piotr Hańczyc 

Number of co-investigators in the project: 4

Call: SONATA 17 - announced on 2021-09-15

Amount awarded: 1 194 000 PLN

Project start date (Y-m-d): 2022-11-28

Project end date (Y-m-d): 2026-07-27

Project duration:: 44 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. Thioflavin T Lasing Probe for Mucin Detection in Simulated Tears as a Targeting Strategy for Brain Tumors
    Authors:
    Ewelina Jalonicka, Konstantin Rusakov, Grzegorz Szwachta, Piotr Hanczyc
    Academic press:
    ACS Chemical Neuroscience (rok: 2025, tom: 16, strony: 2371–2375), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acschemneuro.5c00274 - link to the publication
  2. Photonics of Hydrothermally Treated β-Lactoglobulin Amyloids
    Authors:
    Piotr Hanczyc, Serena Rosa Alfarano, Sreenath Bolisetty, Jiangtao Zhou, Mohammad Peydayesh, Viviane Lutz-Bueno, Ana Diaz, Shrestha Roy Goswami, Maarten T. P. Beerepoot, Mohammad Mehboob Alam, Lei Wang, Niclas Solin, Iwona Szymanska, Raffaele Mezzenga
    Academic press:
    Small Science (rok: 2024, tom: 4, strony: 2400054), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/smsc.202400054 - link to the publication
  3. Collective methodological emission assay of Thioflavin T for qualitative α-synuclein fibril structures discrimination
    Authors:
    Grzegorz Szwachta, Darius Sulskis, Aleksandra Konopka, Ewelina Jalonicka, Karol Struniawski, Kamile Mikalauskaite, Andrius Sakalauskas, Ryszard Kozera, Vytautas Smirnovas, Vitali Stsiapura, Mantas Ziaunys, Piotr Hanczyc
    Academic press:
    International Journal of Biological Macromolecules (rok: 2026, tom: 335, strony: 148994), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ijbiomac.2025.148994 - link to the publication
  4. Influence of Starch-Granule Diameter on Lasing Thresholds of the Molecular Rotor Thioflavin T in a Dual-Cavity Fabry–Perot/Whispering Gallery Mode
    Authors:
    Katarzyna Szajko, Konstantin Rusakov, Piotr Hanczyc
    Academic press:
    ACS Omega (rok: 2025, tom: 10, strony: 38852–38858), Wydawca: Americal Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsomega.5c04338 - link to the publication
  5. Photoluminescence Enhancement and Dual-State Emission in Thioflavin T Aggregates Embedded in Nanoporous Anodic Alumina Photonic Crystals Using Micellar Solubilization
    Authors:
    Grzegorz Szwachta, Barbara Pałys, Piotr Hanczyc
    Academic press:
    The Journal of Physical Chemistry C (rok: 2025, tom: 129, strony: 14551–14558), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcc.5c02612 - link to the publication
  6. Role of Alkali Cations in DNA–Thioflavin T Interaction
    Authors:
    P. Hanczyc
    Academic press:
    The Journal of Physical Chemistry B (rok: 2024, tom: 128, strony: 7520–7529), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.4c02417 - link to the publication
  7. Cavity Lasing Characteristics of Thioflavin T and Thioflavin X in Different Solvents and Their Interaction with DNA for the Controlled Reduction of a Light Amplification Threshold in Solid-State Biofilms
    Authors:
    K. Rusakov, S. Demianiuk, E. Jalonicka, and P. Hanczyc
    Academic press:
    ACS Applied Optical Materials (rok: 2023, tom: 12, strony: 1922–1929), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsaom.3c00264 - link to the publication
  8. Cavity Lasing of Thioflavin T in the Condensed Phase for Discrimination between Surface Interaction and β-Sheet Groove Binding in Alzheimer-Linked Peptides
    Authors:
    P. Hanczyc
    Academic press:
    The Journal of Physical Chemistry Letters (rok: 2024, tom: 15, strony: 9543–9547), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpclett.4c01709 - link to the publication
  9. Thioflavin T─a Reporter of Microviscosity in Protein Aggregation Process: The Study Case of α-Synuclein
    Authors:
    Konstantin Rusakov, Aadil El-Turabi, Lasse Reimer, Poul Henning Jensen, Piotr Hanczyc
    Academic press:
    The Journal of Physical Chemistry Letters (rok: 2024, tom: 15, strony: 6685–6690), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpclett.4c00699 - link to the publication

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