Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Reversible modulation of G-quadruplex functions using photoresponsive ligands - in vitro and cellular studies

2021/43/D/ST4/00997

Keywords:

molecular switches photoisomerization DNA binders G-quadruplex supramolecular chemistry photoswitching DNA regulation spectroscopy

Descriptors:

  • ST4_009:
  • ST4_012:
  • ST4_002:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Politechnika Wrocławska

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marta Maria Dudek 

Number of co-investigators in the project: 4

Call: SONATA 17 - announced on 2021-09-15

Amount awarded: 1 052 128 PLN

Project start date (Y-m-d): 2022-07-01

Project end date (Y-m-d): 2027-05-31

Project duration:: 59 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. A Rationally Designed Azobenzene Photoswitch for DNA G-Quadruplex Regulation in Live Cells
    Authors:
    Marta Dudek, Lucía López-Pacios, Nasim Sabouri, Juan J. Nogueira, Lara Martinez-Fernandez, Marco Deiana
    Academic press:
    Angewandte Chemie International Edition (rok: 2024, tom: 64, strony: e202413000), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/anie.202413000 - link to the publication
  2. Light-Activated Molecules Targeting G-Quadruplex Nucleic Acids
    Authors:
    Marta Dudek, Clément Cabanetos, Marco Deiana
    Academic press:
    Chemistry- A European Journal (rok: 2025, tom: 31, strony: e202501545), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/chem.202501545 - link to the publication
  3. Tunable G-quadruplex ligands: azobenzene derivatives for light-controlled DNA modulation
    Authors:
    Aleksandra A. Matusiak, Mateusz P. Drąg, Marco Deiana, Mikołaj Janicki, Marta M. Dudek
    Academic press:
    Chemistry- A European Journal (rok: 2025, tom: 31, strony: e202404365), Wydawca: Wiley-VCH
    Status:
    Published
    DOI:
    10.1002/chem.202404365 - link to the publication
  4. Harnessing Light for G‑Quadruplex Modulation: Dual Isomeric Effects of an Ortho-Fluoroazobenzene Derivative
    Authors:
    Marta Dudek, Lucía López-Pacios, Nasim Sabouri, Juan J. Nogueira, Lara Martinez-Fernandez, Marco Deiana
    Academic press:
    The Journal of Physical Chemistry Letters (rok: 2024, tom: 15, strony: 9757−9765), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpclett.4c02285 - link to the publication

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