Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Metabolic reprogramming in age-dependent endothelial dysfunction and vascular stiffness; novel mechanism of inflamm-ageing"

2021/42/A/NZ4/00273

Keywords:

endothelium endothelial dysfunction microcirculation artery stiffness metabolic reprogramming vascular inflammation ageing

Descriptors:

  • NZ5_003:
  • NZ4_011:
  • NZ7_014:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Stefan Karol Chłopicki 

Number of co-investigators in the project: 8

Call: MAESTRO 13 - announced on 2021-06-15

Amount awarded: 4 922 360 PLN

Project start date (Y-m-d): 2022-03-24

Project end date (Y-m-d): 2026-03-23

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (9)
  1. Functional deterioration of vascular mitochondrial and glycolytic capacity in the aortic rings of aged mice
    Authors:
    Agnieszka Karaś, Anna Bar, Kanchana Pandian, Agnieszka Jasztal, Zuzanna Kuryłowicz, Barbara Kutryb‑Zając, Elżbieta Buczek, Stefano Rocchetti, Tasnim Mohaissen, Agata Jędrzejewska, Amy C. Harms, Patrycja Kaczara, Stefan Chłopicki
    Academic press:
    GeroScience (rok: 2024, tom: 46, strony: 3831–3844), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11357-024-01091-6 - link to the publication
  2. Vascular ATGL‑dependent lipolysis and the activation of cPLA2– PGI2 pathway protect against postprandial endothelial dysfunction
    Authors:
    M. Sternak, M. Stojak, T. Banasik, A. Kij, A. Bar, M. Z. Pacia, K. Wojnar‑Lason, N. Chorazy, T. Mohaissen, B. Marczyk, I. Czyzynska‑Cichon, Z. Berkimbayeva, A. Mika, S. Chlopicki
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2024, tom: 81, strony: nie dotyczy), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-024-05167-6 - link to the publication
  3. Chymase-independent vascular Ang-(1–12)/Ang II pathway and TXA2 generation are involved in endothelial dysfunction in the murine model of heart failure
    Authors:
    Tasnim Mohaissen, Agnieszka Kij, Anna Bar, Brygida Marczyk, Kamila Wojnar-Lason, Elzbieta Buczek, Agnieszka Karas, Ana B. Garcia-Redondo, Ana M. Briones, Stefan Chlopicki
    Academic press:
    European Journal of Pharmacology (rok: 2024, tom: 966, strony: nie dotyczy), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2023.176296 - link to the publication
  4. Chronic heart failure induces early defenestration of liver sinusoidal endothelial cells (LSECs) in mice
    Authors:
    Kamila Wojnar-Lason, Urszula Tyrankiewicz, Agnieszka Kij, Anna Kurpinska, Patrycja Kaczara, Grzegorz Kwiatkowski, Natalia Wilkosz, Magdalena Giergiel, Marta Stojak, Marek Grosicki, Tasnim Mohaissen, Agnieszka Jasztal, Zuzanna Kurylowicz, Marek Szymonski, Izabela Czyzynska-Cichon, Stefan Chlopicki
    Academic press:
    Acta Psysiologica (rok: 2024, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1007/s11357-024-01086-3 - link to the publication
  5. Upregulation of ALOX12-12-HETE pathway impairs AMPK-dependent modulation of vascular metabolism in ApoE/LDLR - / - mice
    Authors:
    Mariola Olkowicz, Agnieszka Karas , Piotr Berkowicz, Patrycja Kaczara , Agnieszka Jasztal, Zuzanna Kurylowicz, Filip Fedak, Hernando Rosales-Solano, Kanchan Sinha Roy, Agnieszka Kij, Elzbieta Buczek, Janusz Pawliszyn, Stefan Chlopicki
    Academic press:
    Pharmacological Research (rok: 2024, tom: 210, strony: nie), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.phrs.2024.107478 - link to the publication
  6. Liver sinusoidal endothelial cells rely on oxidative phosphorylation but avoid processing long‑chain fatty acids in their mitochondria
    Authors:
    Patrycja Kaczara, Izabela Czyzynska‑Cichon, Edyta Kus, Anna Kurpinska, Mariola Olkowicz, Kamila Wojnar‑Lason, Marta Z. Pacia, Olena Lytvynenko, Myriam Baes and Stefan Chlopicki
    Academic press:
    Cellular & Molecular Biology Letters (rok: 2024, tom: 67, strony: nie dotyczy), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1186/s11658-024-00584-8 - link to the publication
  7. Vascular protein disulfide isomerase A1 mediates endothelial dysfunction induced by angiotensin II in mice
    Authors:
    Agnieszka Kij, Anna Bar, Izabela Czyzynska-Cichon, Kamil Przyborowski, Bartosz Proniewski, Lukasz Mateuszuk, Zuzanna Kurylowicz, Agnieszka Jasztal, Elzbieta Buczek, Anna Kurpinska, Joanna Suraj-Prazmowska, Brygida Marczyk, Karolina Matyjaszczyk-Gwarda, Andreas Daiber, Matthias Oelze, Maria Walczak, Stefan Chlopicki
    Academic press:
    Acta Psysiologica (rok: 2024, tom: nie dotyczy, strony: nie dotyczy), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/apha.14116 - link to the publication
  8. Accelerated ageing and coronary microvascular dysfunction in chronic heart failure in Tgαq*44 mice
    Authors:
    Piotr Berkowicz · Justyna Totoń‑Żurańska · Grzegorz Kwiatkowski · Agnieszka Jasztal · Tamás Csípő · Kamil Kus · Urszula Tyrankiewicz · Anna Orzyłowska · Paweł Wołkow · Attila Tóth · Stefan Chlopicki
    Academic press:
    GeroScience (rok: 2023, tom: 45, strony: 1619–1648), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11357-022-00716-y - link to the publication
  9. Epigenetic clock in the aorta and age‑related endothelial dysfunction in mice
    Authors:
    Ewelina Pośpiech, Anna Bar, Aleksandra Pisarek‑Pacek, Agnieszka Karaś, Wojciech Branicki, Stefan Chlopicki
    Academic press:
    GeroScience (rok: 2024, tom: 46, strony: 3993–4002), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11357-024-01086-3 - link to the publication

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