Metabolic reprogramming in age-dependent endothelial dysfunction and vascular st

Metabolic reprogramming in age-dependent endothelial dysfunction and vascular stiffness; novel mechanism of inflamm-ageing"

2021/42/A/NZ4/00273

Keywords

Descriptors

NZ5_003: Patogeneza chorób człowieka
NZ4_011: Metabolizm
NZ7_014: Farmacja, farmakoterapia, farmakologia

Panel

NZ4 – Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution

Uniwersytet Jagielloński, Jagiellońskie Centrum Rozwoju Leków (JCET)

Voivodeship: małopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Stefan Karol Chłopicki

Number of co-investigators in the project: 8

Call

MAESTRO 13 – announced on 2021-06-15

Amount awarded: 4 922 360 PLN
Project start date: 2022-03-24
Project end date: 2027-03-23
Project duration: 60 months (the same as in the proposal)
Project status: Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (9)

Epigenetic clock in the aorta and age‑related endothelial dysfunction in mice

Authors:
Ewelina Pośpiech, Anna Bar, Aleksandra Pisarek‑Pacek, Agnieszka Karaś, Wojciech Branicki, Stefan Chlopicki

Academic press:
GeroScience (year: 2024, volume: 46, pages: 3993–4002), Publisher: Springer

Status:
Published

DOI:
10.1007/s11357-024-01086-3 – link to the publication
Accelerated ageing and coronary microvascular dysfunction in chronic heart failure in Tgαq*44 mice

Authors:
Piotr Berkowicz · Justyna Totoń‑Żurańska · Grzegorz Kwiatkowski · Agnieszka Jasztal · Tamás Csípő · Kamil Kus · Urszula Tyrankiewicz · Anna Orzyłowska · Paweł Wołkow · Attila Tóth · Stefan Chlopicki

Academic press:
GeroScience (year: 2023, volume: 45, pages: 1619–1648), Publisher: Springer

Status:
Published

DOI:
10.1007/s11357-022-00716-y – link to the publication
Vascular ATGL‑dependent lipolysis and the activation of cPLA2– PGI2 pathway protect against postprandial endothelial dysfunction

Authors:
M. Sternak, M. Stojak, T. Banasik, A. Kij, A. Bar, M. Z. Pacia, K. Wojnar‑Lason, N. Chorazy, T. Mohaissen, B. Marczyk, I. Czyzynska‑Cichon, Z. Berkimbayeva, A. Mika, S. Chlopicki

Academic press:
Cellular and Molecular Life Sciences (year: 2024, volume: 81, pages: nie dotyczy), Publisher: Springer

Status:
Published

DOI:
10.1007/s00018-024-05167-6 – link to the publication
Chymase-independent vascular Ang-(1–12)/Ang II pathway and TXA2 generation are involved in endothelial dysfunction in the murine model of heart failure

Authors:
Tasnim Mohaissen, Agnieszka Kij, Anna Bar, Brygida Marczyk, Kamila Wojnar-Lason, Elzbieta Buczek, Agnieszka Karas, Ana B. Garcia-Redondo, Ana M. Briones, Stefan Chlopicki

Academic press:
European Journal of Pharmacology (year: 2024, volume: 966, pages: nie dotyczy), Publisher: Elsevier B.V.

Status:
Published

DOI:
10.1016/j.ejphar.2023.176296 – link to the publication
Chronic heart failure induces early defenestration of liver sinusoidal endothelial cells (LSECs) in mice

Authors:
Kamila Wojnar-Lason, Urszula Tyrankiewicz, Agnieszka Kij, Anna Kurpinska, Patrycja Kaczara, Grzegorz Kwiatkowski, Natalia Wilkosz, Magdalena Giergiel, Marta Stojak, Marek Grosicki, Tasnim Mohaissen, Agnieszka Jasztal, Zuzanna Kurylowicz, Marek Szymonski, Izabela Czyzynska-Cichon, Stefan Chlopicki

Academic press:
Acta Psysiologica (year: 2024, volume: nie dotyczy, pages: nie dotyczy), Publisher: Wiley

Status:
Published

DOI:
10.1007/s11357-024-01086-3 – link to the publication
Vascular protein disulfide isomerase A1 mediates endothelial dysfunction induced by angiotensin II in mice

Authors:
Agnieszka Kij, Anna Bar, Izabela Czyzynska-Cichon, Kamil Przyborowski, Bartosz Proniewski, Lukasz Mateuszuk, Zuzanna Kurylowicz, Agnieszka Jasztal, Elzbieta Buczek, Anna Kurpinska, Joanna Suraj-Prazmowska, Brygida Marczyk, Karolina Matyjaszczyk-Gwarda, Andreas Daiber, Matthias Oelze, Maria Walczak, Stefan Chlopicki

Academic press:
Acta Psysiologica (year: 2024, volume: nie dotyczy, pages: nie dotyczy), Publisher: Wiley

Status:
Published

DOI:
10.1111/apha.14116 – link to the publication
Functional deterioration of vascular mitochondrial and glycolytic capacity in the aortic rings of aged mice

Authors:
Agnieszka Karaś, Anna Bar, Kanchana Pandian, Agnieszka Jasztal, Zuzanna Kuryłowicz, Barbara Kutryb‑Zając, Elżbieta Buczek, Stefano Rocchetti, Tasnim Mohaissen, Agata Jędrzejewska, Amy C. Harms, Patrycja Kaczara, Stefan Chłopicki

Academic press:
GeroScience (year: 2024, volume: 46, pages: 3831–3844), Publisher: Springer

Status:
Published

DOI:
10.1007/s11357-024-01091-6 – link to the publication
Upregulation of ALOX12-12-HETE pathway impairs AMPK-dependent modulation of vascular metabolism in ApoE/LDLR - / - mice

Authors:
Mariola Olkowicz, Agnieszka Karas , Piotr Berkowicz, Patrycja Kaczara , Agnieszka Jasztal, Zuzanna Kurylowicz, Filip Fedak, Hernando Rosales-Solano, Kanchan Sinha Roy, Agnieszka Kij, Elzbieta Buczek, Janusz Pawliszyn, Stefan Chlopicki

Academic press:
Pharmacological Research (year: 2024, volume: 210, pages: nie), Publisher: Elsevier B.V.

Status:
Published

DOI:
10.1016/j.phrs.2024.107478 – link to the publication
Liver sinusoidal endothelial cells rely on oxidative phosphorylation but avoid processing long‑chain fatty acids in their mitochondria

Authors:
Patrycja Kaczara, Izabela Czyzynska‑Cichon, Edyta Kus, Anna Kurpinska, Mariola Olkowicz, Kamila Wojnar‑Lason, Marta Z. Pacia, Olena Lytvynenko, Myriam Baes and Stefan Chlopicki

Academic press:
Cellular & Molecular Biology Letters (year: 2024, volume: 67, pages: nie dotyczy), Publisher: Springer

Status:
Published

DOI:
10.1186/s11658-024-00584-8 – link to the publication

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