Deciphering how viral epitranscriptome shapes host immune response.

2021/42/E/NZ1/00314

Keywords

Descriptors

NZ1_001: Biologia molekularna
NZ6_001: Odporność swoista i nieswoista
NZ1_002: Biochemia

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Uniwersytet Warszawski, Wydział Biologii

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Paweł Jan Sikorski

Number of co-investigators in the project: 6

Call

SONATA BIS 11 – announced on 2021-06-15

Amount awarded: 3 996 720 PLN
Project start date: 2022-04-25
Project end date: 2027-09-24
Project duration: 65 months (the same as in the proposal)
Project status: Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (3)

2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion

Authors:
Karolina Drazkowska, Rafal Tomecki, Marcin Warminski, Natalia Baran, Dominik Cysewski, Anaïs Depaix, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity, Pawel J Sikorski

Academic press:
Nucleic Acids Research (year: 2022, volume: 50(16), pages: 9051–9071), Publisher: Oxford University Press

Status:
Published

DOI:
10.1093/nar/gkac722 – link to the publication
Effective recognition of double-stranded RNA does not require activation of cellular inflammation

Authors:
Karolina Drazkowska, Julia Cieslicka, Michal Kitowicz, Anna Pastucha, Lukasz Markiewicz, Wiktoria Szymanek, Krzysztof Goryca, Tomasz Kowalczyk, Dominik Cysewski, Andreas R. Bausch, Pawel J. Sikorski

Academic press:
Science Advances (year: 2025, volume: 11, pages: 46041), Publisher: American Association for the Advancement of Science

Status:
Published

DOI:
10.1126/sciadv.ads6498 – link to the publication
Expanding the Available RNA Labeling Toolbox With CutA Nucleotidyltransferase for Efficient Transcript Labeling with Purine and Pyrimidine Nucleotide Analogs

Authors:
Rafal Tomecki, Karolina Drazkowska, Rafal Madaj, Adam Mamot, Stanislaw Dunin-Horkawicz, Pawel J. Sikorski

Academic press:
ChemBioChem (year: 2024, volume: 25, pages: e202400202 (1 - 9)), Publisher: John Wiley & Sons, Inc

Status:
Published

DOI:
10.1002/cbic.202400202 – link to the publication

« New search

Projects search