Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Deciphering how viral epitranscriptome shapes host immune response.

2021/42/E/NZ1/00314

Keywords:

viral RNA double-stranded RNA RNA stability RNA immunogenicity RNA interference translational regulation ribosome composition RNA splicing cap structure 2'-O methylation N6-methyladenosine 5-methylcytosine pseudouridine A-to-I editing

Descriptors:

  • NZ1_001:
  • NZ6_001:
  • NZ1_002:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Paweł Jan Sikorski 

Number of co-investigators in the project: 6

Call: SONATA BIS 11 - announced on 2021-06-15

Amount awarded: 3 996 720 PLN

Project start date (Y-m-d): 2022-04-25

Project end date (Y-m-d): 2027-04-24

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (2)
  1. Expanding the Available RNA Labeling Toolbox With CutA Nucleotidyltransferase for Efficient Transcript Labeling with Purine and Pyrimidine Nucleotide Analogs
    Authors:
    Rafal Tomecki, Karolina Drazkowska, Rafal Madaj, Adam Mamot, Stanislaw Dunin-Horkawicz, Pawel J. Sikorski
    Academic press:
    ChemBioChem (rok: 2024, tom: 25, strony: e202400202 (1 - 9)), Wydawca: John Wiley & Sons, Inc
    Status:
    Published
    DOI:
    10.1002/cbic.202400202 - link to the publication
  2. 2′-O-Methylation of the second transcribed nucleotide within the mRNA 5′ cap impacts the protein production level in a cell-specific manner and contributes to RNA immune evasion
    Authors:
    Karolina Drazkowska, Rafal Tomecki, Marcin Warminski, Natalia Baran, Dominik Cysewski, Anaïs Depaix, Renata Kasprzyk, Joanna Kowalska, Jacek Jemielity, Pawel J Sikorski
    Academic press:
    Nucleic Acids Research (rok: 2022, tom: 50(16), strony: 9051–9071), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkac722 - link to the publication

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