Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Role of DPPIV family proteases in transposon silencing and genome maintenance

2021/42/E/NZ1/00336

Keywords:

C. elegans Proteases small noncoding RNAs transposons,

Descriptors:

  • NZ1_001:
  • NZ2_003:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Centrum Zaawansowanych Technologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Rajani Kanth Gudipatti 

Number of co-investigators in the project: 4

Call: SONATA BIS 11 - announced on 2021-06-15

Amount awarded: 3 470 453 PLN

Project start date (Y-m-d): 2022-08-01

Project end date (Y-m-d): 2027-07-31

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. IGF2BPs directly regulate the noncanonical translation of toxic proteins from mutant FMR1 mRNA containing expanded CGG repeats
    Authors:
    Anna Baud, Damini Saha, Tomasz Skrzypczak, Izabela Broniarek, Daria Niewiadomska, Wojciech J Szlachcic, Malgorzata Borowiak, Rajani Kanth Gudipati, Krzysztof Sobczak
    Academic press:
    Nature communications (rok: 2024, tom: 17(1), strony: 569), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41467-025-67261-y - link to the publication
  2. Deep quantification of substrate turnover defines protease subsite cooperativity
    Authors:
    Rajani Kanth Gudipati , Dimos Gaidatzis , Jan Seebacher , Sandra Muehlhaeusser , Georg Kempf , Simone Cavadini, Daniel Hess, Charlotte Soneson, Helge Großhans
    Academic press:
    molecular systems biology (rok: 2024, tom: 20, strony: 1303 - 1328), Wydawca: Embo press
    Status:
    Published
    DOI:
    10.1038/s44320-024-00071-4 - link to the publication
  3. Dipeptidyl peptidase DPF-3 is a gatekeeper of microRNA Argonaute compensation in animals
    Authors:
    Louis-Mathieu Harvey, Pierre-Marc Frédérick, Rajani Kanth Gudipati, Pascale Michaud, François Houle, Daniel Young, Catherine Desbiens, Shanna Ladouceur, Antoine Dufour, Helge Großhans & Martin J. Simard
    Academic press:
    Nature communications (rok: 2024, tom: 16(1), strony: 2738), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41467-025-58141-6 - link to the publication

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