Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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The effect of JDP/Hsp70 chaperones on the conformation and stability of foldedprotein substrate

2021/41/B/NZ1/00449

Keywords:

molecular chaperones Hsp70 J-domain proteins JDP HscA HscB IscU ironsulfur cluster biogenesis hydrogen deuterium exchange mass spectrometry

Descriptors:

  • NZ1_001:
  • NZ1_002:
  • NZ1_004:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Gdański, Międzyuczelniany Wydział Biotechnologii Uniwersytetu Gdańskiego i Gdańskiego Uniwersytetu Medycznego

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jarosław Aleksander Marszałek 

Number of co-investigators in the project: 4

Call: OPUS 21 - announced on 2021-03-15

Amount awarded: 1 791 570 PLN

Project start date (Y-m-d): 2022-01-13

Project end date (Y-m-d): 2026-01-12

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Chaperone function in Fe–S protein biogenesis: Three possible scenarios.
    Authors:
    Jaroslaw Marszalek, Elizabeth A. Craig, Marcin Pitek, Rafal Dutkiewicz
    Academic press:
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research (rok: 2024, tom: Volume 1871, Issue 5, strony: 12), Wydawca: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
    Status:
    Published
    DOI:
    10.1016/j.bbamcr.2024.119717 - link to the publication
  2. Interaction of client—the scaffold on which FeS clusters are build—with J-domain protein Hsc20 and its evolving Hsp70 partners
    Authors:
    Jaroslaw Marszalek and Elizabeth A. Craig
    Academic press:
    Frontiers in Molecular Biosciencs (rok: 2022, tom: inne, strony: 12), Wydawca: Frontiers in Molecular Biosciencs
    Status:
    Published
    DOI:
    10.3389/fmolb.2022.1034453 - link to the publication
  3. Analysis of Reconstituted Tripartite Complex Supports Avidity-based Recruitment of Hsp70 by Substrate Bound J-domain Protein
    Authors:
    Marcin Jelen, Igor Grochowina, Aneta Grabinska-Rogala, Szymon J. Ciesielski, Katarzyna Dabrowska, Bartlomiej Tomiczek, Lukasz Nierzwicki, Wojciech Delewski, Brenda Schilke, Jacek Czub, Michal Dadlez, Rafal Dutkiewicz, Elizabeth A. Craig and Jaroslaw Marszalek
    Academic press:
    Journal of Molecular Biology (rok: 2023, tom: inne, strony: 15), Wydawca: Journal of Molecular Biology
    Status:
    Published
    DOI:
    10.1016/j.jmb.2023.168283 - link to the publication
  4. NAC and Zuotin / Hsp70 chaperone systems coexist at the ribosome tunnel exit in vivo
    Authors:
    Thomas Ziegelhoffer , Amit K. Verma, Wojciech Delewski, Brenda A. Schilke, Paige M. Hill, Marcin Pitek, Jaroslaw Marszalek and Elizabeth A. Craig
    Academic press:
    Nucleic Acids Research (rok: 2024, tom: Volume 52, Issue 6, strony: 3346–3357), Wydawca: Nucleic Acids Research
    Status:
    Published
    DOI:
    10.1093/nar/gkae005 - link to the publication

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