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Small, well-armed fighters vs. powerful, devastating enemies - modified peptidecomplexes from human saliva in the fight against pathogenic microbes

2021/41/B/ST4/02654

Keywords:

antimicrobial peptides bioinorganicchemistry saliva peptidomimetics metal ions zinc copper antibiotic resistant bacteria fluorescence UV-Vis CD NMR EPR spectroscopy mass spectrometry ITC potentiometry microbiological studies

Descriptors:

  • ST4_009:
  • ST4_011:
  • ST4_020:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Małgorzata Wątły 

Number of co-investigators in the project: 5

Call: OPUS 21 - announced on 2021-03-15

Amount awarded: 1 927 240 PLN

Project start date (Y-m-d): 2022-02-03

Project end date (Y-m-d): 2026-10-02

Project duration:: 56 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Poly-Gly Region Regulates the Accessibility of Metal Binding Sites in Snake Venom Peptides
    Authors:
    Joanna Wa̧tły*, Aleksandra Hecel, Robert Wieczorek, Magdalena Rowińska-Żyrek, and Henryk Kozłowski
    Academic press:
    Inorganic Chemistry (rok: 2022, tom: 61, 36, strony: 14247–14251), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.2c02584 - link to the publication
  2. CH vs. HC—Promiscuous Metal Sponges in Antimicrobial Peptides and Metallophores
    Authors:
    Garstka Kinga, Dzyhovskyi Valentyn, Wątły Joanna, Stokowa-Sołtys Kamila, Świątek-Kozłowska Jolanta, Kozłowski Henryk, Barceló-Oliver Miquel, Bellotti Denise, Rowińska-Żyrek Magdalena
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 3985/1-3985/14), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28103985 - link to the publication
  3. Zn(II) Induces Fibril Formation and Antifungal Activity in Shepherin I, An Antimicrobial Peptide from Capsella bursa-pastoris
    Authors:
    Wątły Joanna, Szarszoń Klaudia, Mikołajczyk Aleksandra, Grelich-Mucha Manuela, Matera-Witkiewicz Agnieszka, Olesiak-Bańska Joanna, Rowińska-Żyrek Magdalena
    Academic press:
    Inorganic Chemistry (rok: 2023, tom: 62, strony: 19786-19794), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/acs.inorgchem.3c03409 - link to the publication
  4. CH vs. HC—Promiscuous Metal Sponges in Antimicrobial Peptides and Metallophores
    Authors:
    Garstka Kinga, Dzyhovskyi Valentyn, Wątły Joanna, Stokowa-Sołtys Kamila, Świątek-Kozłowska Jolanta, Kozłowski Henryk, Barceló-Oliver Miquel, Bellotti Denise, Rowińska-Żyrek Magdalena
    Academic press:
    Molecules (rok: 2023, tom: 28, strony: 3985/1-3985/14), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/molecules28103985 - link to the publication
  5. Oddziaływanie przeciwdrobnoustrojowych peptydów z jonami metali - Relacja między chemią koordynacyjną, strukturą, termodynamiką a sposobem działania = The interaction of antimicrobial peptides with metal ions - The realationship between coordination chemistry, structure, termodynamics and mode of action
    Authors:
    Dudek Dorota, Garstka Kinga, Miller Adriana, Dzień Emilia, Wątły Joanna, Hecel Aleksandra, Kozłowski Henryk, Rowińska-Żyrek Magdalena
    Academic press:
    Wiadomości Chemiczne (rok: 2022, tom: 76, strony: 365-391), Wydawca: Wiadomości Chemiczne
    Status:
    Published
    DOI:
    10.53584/wiadchem.2022.5.7 - link to the publication

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