Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Structure and Function of Protein Corona at the Nanoparticles Interface

2021/41/B/ST5/02233

Keywords:

protein corona drug delivery system multifunctional nanocarriers

Descriptors:

  • ST5_010:
  • ST5_003:
  • ST5_013:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Katalizy i Fizykochemii Powierzchni im. Jerzego Habera PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Barbara Dorota Jachimska 

Number of co-investigators in the project: 9

Call: OPUS 21 - announced on 2021-03-15

Amount awarded: 2 713 900 PLN

Project start date (Y-m-d): 2022-01-11

Project end date (Y-m-d): 2027-01-10

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  • Book publications / chapters in book publications (1)
  1. Theoretical and Experimental Analyses of the Interfacial Mechanism of Dendrimer-Doxorubicin Complex Formation
    Authors:
    Jachimska B., Goncerz M., Wolski P., Meldrum C., Lustyk Ł., Panczyk T
    Academic press:
    Molecular Pharmaceutics (rok: 2024, tom: 21, strony: 5892-5904), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.molpharmaceut.4c00941 - link to the publication
  2. Effect of Ionization Degree of Poly(amidoamine) Dendrimer and 5-Fluorouracil on the Efficiency of Complex Formation—A Theoretical and Experimental Approach
    Authors:
    M. Szota.; Wolski, P.; Carucci, C.; Marincola, F.C.; Gurgul, J.; Panczyk, T.; Salis, A.; Jachimska, B
    Academic press:
    International Journal of Molecular Sciences (rok: 2023, tom: 24, strony: 819), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms24010819 - link to the publication
  3. Mechanistic Insights into Protein Corona Formation: The Surface Charge of Mesoporous Silica Nanoparticles Determines the Orientation and the Conformation of Adsorbed BSA Protein
    Authors:
    Alessandra Ballicu, Gaia Maria Meloni, Matteo Farci, Davide Tocco, Marco Piludu, Drew F. Parsons, Cristina Carucci, Barbara Jachimska, and Andrea Salis
    Academic press:
    Langmuir (rok: 2026, tom: -, strony: -), Wydawca: ACS
    Status:
    Published
    DOI:
    10.1021/acs.langmuir.5c06171 - link to the publication
  4. BSA as a platform for designing biologically active nanocarriers– experimental and computational studies
    Authors:
    O. Adamczyk, M. Szota, K. Rakowski, M. Prochownik, D. Doveiko, Y. Chen, B. Jachimska
    Academic press:
    Int. J. Mol. Sci. (rok: 2024, tom: 1, strony: 37), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25010037 - link to the publication
  5. Lipids associated with autophagy: mechanisms and therapeutic targets
    Authors:
    Michał Jarocki, Kacper Turek, Jolanta Saczko, Mounir Tarek & Julita Kulbacka
    Academic press:
    Cell Death Discovery (rok: 2024, tom: 10, strony: 460), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/s41420-024-02224-8 - link to the publication
  6. Dendrimer Platforms for Targeted Doxorubicin Delivery—Physicochemical Properties in Context of Biological Responses
    Authors:
    Szota M., Szwedowicz U., Rembiałowska N., Janicka-Klos A., Doveiko D., Chen Y., Kulbacka J., Jachimska B
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25(13), strony: 7201), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25137201 - link to the publication
  7. Protein-Functionalized Nanoparticles: Emerging Strategies in Drug Delivery
    Authors:
    A. Wietrzyk; A. Hutny; L. Jonderko; K. Biliski; M. Makieła; J. Kalinin; B. Jachimska, J. Kulbacka
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2025, tom: 189, strony: 118337), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2025.118337 - link to the publication
  8. Changes in Secondary Structure and Properties of Bovine Serum Albumin as a Result of Interactions with Gold Surface,
    Authors:
    P. Tworek, K. Rakowski, M. Szota, M. Lekka, B. Jachimska
    Academic press:
    ChemPhysChem (rok: 2023, tom: 2, strony: 46037), Wydawca: Willey
    Status:
    Published
    DOI:
    10.1002/cphc.202300505 - link to the publication
  9. Role of the Surface in Conformational Changes in Lysozymes: Effect of a Gold Surface and a Lipid Membrane
    Authors:
    A. Kaminska; L. Lustyk, J. Gurgul, B. Jachimska
    Academic press:
    International Journal of Molecular Sciences (rok: 2025, tom: 26, strony: 11303), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms262311303 - link to the publication
  10. Effect of alkaline conditions on the formation of an effective G4.0 PAMAM complex with doxorubicin
    Authors:
    M. Szota, B. Jachimska
    Academic press:
    Pharmaceutics (rok: 2023, tom: 15, strony: 875), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15030875 - link to the publication
  1. Probing bio interfaces with biophysical methods: aspects of applying the QCMD method
    Authors:
    T. Kobiela, K. Wojciechowski, and B. Jachimska
    Book:
    Reference Collection in Chemistry, Molecular Sciences and Chemical Engineering (rok: 2023, tom: -, strony: -), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/B978-0-323-85669-0.00076-3 - link to the publication

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