Living on the edge: evolutionary adaptation of substrate-recruiting subunits of the cullin-RING ubiquitin ligase complexes to avoid premature degradation
2021/41/N/NZ1/03473
Keywords
Descriptors
- NZ1_001: Biologia molekularna
- NZ3_001: Biologia komórki
- NZ2_007: Bioinformatyka
Panel
NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology
Host institution
Międzynarodowy Instytut Biologii Molekularnej i Komórkowej
Voivodeship: mazowieckie
Principal investigator (from the host institution)
Number of co-investigators in the project: 2
Call
PRELUDIUM 20 – announced on 2021-03-15
- Amount awarded
- 190 770 PLN
- Project start date
- 2022-02-01
- Project end date
- 2025-01-31
- Project duration
- 36 months (the same as in the proposal)
- Project status
- Project settled
Project description
Download the project description in a pdf file
Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
Publication in academic press/journals (4)
-
In silico analysis of the profilaggrin sequence indicates alterations in the stability, degradation route, and intracellular protein fate in filaggrin null mutation carriers
- Authors:
- Argho Aninda Paul, Natalia A. Szulc, Adrian Kobiela, Sara J. Brown, Wojciech Pokrzywa, Danuta Gutowska-Owsiak
- Academic press:
- Frontiers in Molecular Biosciences (year: 2023, volume: 10, pages: 46045), Publisher: Frontiers
- Status:
- Published
- DOI:
- 10.3389/fmolb.2023.1105678 – link to the publication
-
DEGRONOPEDIA: a web server for proteome-wide inspection of degrons
- Authors:
- Natalia A Szulc, Filip Stefaniak, Małgorzata Piechota, Anna Soszyńska, Gabriela Piórkowska, Andrea Cappannini, Janusz M Bujnicki, Chiara Maniaci, Wojciech Pokrzywa
- Academic press:
- Nucleic Acids Research (year: 2024, volume: 52, pages: W221–W232), Publisher: Oxford Academic
- Status:
- Published
- DOI:
- 10.1093/nar/gkae238 – link to the publication
-
Lysine deserts and cullin-RING ligase receptors: Navigating untrodden paths in proteostasis
- Authors:
- Natalia A. Szulc, Małgorzata Piechota, Lilla Biriczová, Pankaj Thapa, Wojciech Pokrzywa
- Academic press:
- iScience (year: 2023, volume: 26, pages: 46046), Publisher: Cell Press
- Status:
- Published
- DOI:
- 10.1016/j.isci.2023.108344 – link to the publication
-
A novel de novo FEM1C variant is linked to neurodevelopmental disorder with absent speech, pyramidal signs and limb ataxia
- Authors:
- Abhishek Anil Dubey, Magdalena Krygier, Natalia A Szulc, Karolina Rutkowska, Joanna Kosińska, Agnieszka Pollak, Małgorzata Rydzanicz, Tomasz Kmieć, Maria Mazurkiewicz-Bełdzińska, Wojciech Pokrzywa, Rafał Płoski
- Academic press:
- Human Molecular Genetics (year: 2022, volume: 32, pages: 1152–1161), Publisher: Oxford University Press
- Status:
- Published
- DOI:
- 10.1093/hmg/ddac276 – link to the publication