Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Early and late consequences of stem cell compartment damage due to SARS-CoV-2 infection

2021/41/B/NZ6/01590

Keywords:

Nlrp3 inflammasome SARS-CoV-2 ACE2 TLR4 hematopoietic stem cells endothelial progenitors cells

Descriptors:

  • NZ6_001:
  • NZ6_002:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Warszawski Uniwersytet Medyczny

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Magdalena Józefa Kucia 

Number of co-investigators in the project: 5

Call: OPUS 21 - announced on 2021-03-15

Amount awarded: 2 381 440 PLN

Project start date (Y-m-d): 2022-01-21

Project end date (Y-m-d): 2026-01-20

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Proteomic Analysis of Murine Bone Marrow Very Small Embryonic-like Stem Cells at Steady-State Conditions and after In Vivo Stimulation by Nicotinamide and Follicle-Stimulating Factor Reflects their Germ-Lineage Origin and Multi Germ Layer Differentiation Potential
    Authors:
    Chumak V, Sielatycka K, Ciechanowicz A, Bujko K, Ratajczak MZ, Kucia M.
    Academic press:
    Stem Cell Reviews and Reports (rok: 2022, tom: 1, strony: 120-132), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-022-10445-6 - link to the publication
  2. Human CD34+ very small embryonic-like stem cells can give rise to endothelial colony-forming cells with a multistep differentiation strategy using UM171 and nicotinamide acid.
    Authors:
    Domingues A, Rossi E, Bujko K, Detriche G, Richez U, Blandinieres A, Kucia M, Ratajczak J, Smadja DM, Ratajczak MZ.
    Academic press:
    Leukemia (rok: 2022, tom: 5, strony: 1440-1443), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41375-022-01517-0 - link to the publication
  3. Angiotensin 1-7 Stimulates Proliferation of Lung Bronchoalveolar Progenitors-Implications for SARS-CoV-2 Infection
    Authors:
    Ciechanowicz AK, Lay WX, Prado Paulino J, Suchocki E, Leszczak S, Leszczak C, Kucia M.
    Academic press:
    Cells (rok: 2022, tom: 13, strony: 45672), Wydawca: mdpi
    Status:
    Published
    DOI:
    10.3390/cells11132102 - link to the publication