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Role of Nox2-ROS-Nlrp3 inflammasome axis in homing and engraftment of hematopoietic stem/progenitor cells

2021/41/B/NZ3/01589

Keywords

Descriptors

  • NZ3_001: Biologia komórki
  • NZ3_008: Komórki macierzyste
  • NZ3_007: Przekaźnictwo sygnału

Panel

NZ3 – Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution

Warszawski Uniwersytet Medyczny

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Mariusz Zdzisław Ratajczak

Number of co-investigators in the project: 5

Call

OPUS 21 – announced on 2021-03-15

Amount awarded
2 405 840 PLN
Project start date
2022-01-21
Project end date
2026-05-20
Project duration
52 months (the same as in the proposal)
Project status
Project completed

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (17)

  1. Hematopoiesis Revolves Around the Primordial Evolutional Rhythm of Purinergic Signaling and Innate Immunity - A Journey to the Developmental Roots

    Authors:
    Ratajczak, M. Z., Bujko, K., Brzezniakiewicz-Janus, K., Ratajczak, J., & Kucia, M.
    Academic press:
    Stem cell reviews and reports (year: 2024, volume: 20, pages: 827-838), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10692-9 – link to the publication

  2. Intracellular Complement (Complosome) is Expressed in Several Types of Human Adult Bone Marrow-Derived Stem Cells

    Authors:
    Bujko, K., Brzenziakiewicz-Janus, K., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (year: 2024, volume: 20, pages: 437-439), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-023-10650-x – link to the publication

  3. Defect in Migration of HSPCs in Nox-2 Deficient Mice Explained by Impaired Activation of Nlrp3 Inflammasome and Impaired Formation of Membrane Lipid Rafts

    Authors:
    Brzezniakiewicz-Janus, K., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (year: 2024, volume: 21(1), pages: 45-58), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10775-7 – link to the publication

  4. Murine and Human-Purified very Small Embryonic-like Stem Cells (VSELs) Express Purinergic Receptors and Migrate to Extracellular ATP Gradient.

    Authors:
    Bujko, K., Brzezniakiewicz-Janus, K., Jarczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (year: 2024, volume: 20 (5), pages: 1357-1366), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10716-4 – link to the publication

  5. Hematopoiesis Revolves Around the Primordial Evolutional Rhythm of Purinergic Signaling and Innate Immunity - A Journey to the Developmental Roots

    Authors:
    Ratajczak MZ, Bujko K, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M
    Academic press:
    Stem cell reviews and reports (year: 2023, volume: 1, pages: 46034), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-024-10692-9 – link to the publication

  6. NADPH oxidase isoform NOX-2 deficiency affects mitochondrial oxygen consumption and metabolic flexibility

    Authors:
    Thetchinamoorthy, K., Wierzbicka, D., Waraksa-Zasada, E., Kazek, M., Konopko, A., Ratajczak, M. Z., & Kucia, M.
    Academic press:
    Redox biology (year: 2025, volume: 88, pages: 103948), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.redox.2025.103948 – link to the publication

  7. Pineal Gland Hormone Melatonin Inhibits Migration of Hematopoietic Stem/Progenitor Cells (HSPCs) by Downregulating Nlrp3 Inflammasome and Upregulating Heme Oxygenase-1 (HO-1) Activity

    Authors:
    Abdelbaset-Ismail, A., Brzezniakiewicz-Janus, K., Thapa, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (year: 2024, volume: 20, pages: 237-246), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-023-10638-7 – link to the publication

  8. Intracellular Complement (Complosome) is Expressed in Several Types of Human Adult Bone Marrow-Derived Stem Cells

    Authors:
    Bujko K, Brzenziakiewicz-Janus K, Kucia M, Ratajczak MZ
    Academic press:
    Stem cell reviews and reports (year: 2024, volume: 20, pages: 437-439), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-023-10650-x – link to the publication

  9. The Different Responsiveness of C3- and C5-deficient Murine BM Cells to Oxidative Stress Explains Why C3 Deficiency, in Contrast to C5 Deficiency, Correlates with Better Pharmacological Mobilization and Engraftment of Hematopoietic Cells

    Authors:
    Konopko, A., Łukomska, A., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (year: 2024, volume: 21(1), pages: 59-67), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-024-10792-6 – link to the publication

  10. UDP-Glucose-P2Y14 Receptor Signaling Enhances the Responsiveness of Hematopoietic Stem/Progenitor Cells to Chemoattractants by Facilitating Membrane Lipid Raft Formation and Nlrp3 Inflammasome Activation

    Authors:
    Adamiak, M., Thetchinamoorthy, K., Wierzbicka, D., Kazek, M., Waraksa-Zasada, E., Lukomska, A., Brzezniakiewicz-Janus, K., Ratajczak, J., Kucia, M., & Z Ratajczak, M.
    Academic press:
    Stem cell reviews and reports (year: 2026, volume: 26, pages: s12015), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-026-11104-w – link to the publication

  11. Very small embryonic-like stem cells (VSELs) on the way for potential applications in regenerative medicine

    Authors:
    Thetchinamoorthy, K., Jarczak, J., Kieszek, P., Wierzbicka, D., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Frontiers in bioengineering and biotechnology (year: 2025, volume: 13, pages: 1564964), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fbioe.2025.1564964 – link to the publication

  12. Complosome Regulates Hematopoiesis at the Mitochondria Leve

    Authors:
    Konopko, A., Łukomska, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (year: 2025, volume: 10,1007, pages: s12015-025), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-10856-1 – link to the publication

  13. The Nox2-ROS-Nlrp3 Inflammasome Signaling Stimulates in the Hematopoietic Stem/Progenitor Cells Lipogenesis to Facilitate Membrane Lipid Raft Formation

    Authors:
    Abdelbaset-Ismail A, Ciechanowicz AK, Bujko K, Ratajczak J, Kucia M, Ratajczak MZ.
    Academic press:
    Stem Cell Reviews and Reports (year: 2022, volume: 19, pages: 92-103), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-022-10481-2 – link to the publication

  14. The NLRP3 Inflammasome Transmits Sterile Inflammation Signals to Sustain Proper Mitochondrial Electron Transport Chain Function and Influences Cellular Metabolism

    Authors:
    Konopko, A., Kazek, M., Waraksa-Zasada, E., Łukomska, A., Ratajczak, J., Kucia, M., & Ratajczak, M. Z.
    Academic press:
    Stem cell reviews and reports (year: 2025, volume: 21, pages: 2157-2169), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-10948-y – link to the publication

  15. Optimizing single cell RNA sequencing of stem cells. A streamlined workflow for enhanced sensitivity and reproducibility in hematopoietic studies. The use of human umbilical cord blood-derived hematopoietic stem and progenitor cells

    Authors:
    Jarczak, J., Kieszek, P., Ratajczak, M. Z., & Kucia, M.
    Academic press:
    Frontiers in cell and developmental biology (year: 2025, volume: 13, pages: 1590889), Publisher: Frontiers
    Status:
    Published
    DOI:
    10.3389/fcell.2025.1590889 – link to the publication

  16. Complosome Activation after Myocardial Infarction in a Murine Model of Permanent LAD Ligation

    Authors:
    Ratajczak, J., Abdel-Latif, A., Schneider, G., Luther, T., Chaudhary, R., Shabani, P., Lopez, R., Alzamrooni, A., Singh, A. P., Jama, H., Kakar, S. S., Kucia, M., & Ratajczak, M.
    Academic press:
    Stem cell reviews and reports (year: 2026, volume: 22, pages: 1023-1029), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s12015-025-11044-x – link to the publication

  17. Extracellular Adenosine (eAdo) - A2B Receptor Axis Inhibits in Nlrp3 Inflammasome-dependent Manner Trafficking of Hematopoietic Stem/progenitor Cells.

    Authors:
    Thapa A, Abdelbaset-Ismail A, Chumak V, Adamiak M, Brzezniakiewicz-Janus K, Ratajczak J, Kucia M, Ratajczak MZ.
    Academic press:
    Stem Cell Reviews and Reports (year: 2022, volume: 18, pages: 2893-2911), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-022-10417-w – link to the publication

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Graphic design and implementation: Jakub Piotrowski