Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The interactome of Upf1 (Nam7) ubiquitin ligase - deciphering thesubstrates and novel biological functions

2021/41/N/NZ2/00551

Keywords:

ubiquitination ubiquitin ligase Upf1 (Nam7) yeast Saccharomyces cerevisiae protein-protein interactions proteomics luciferase NanoLuc NanoBiT

Descriptors:

  • NZ2_003:
  • NZ2_009:
  • NZ3_001:

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Wrocławski, Wydział Nauk Biologicznych

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Natalia Joanna Łazarewicz 

Number of co-investigators in the project: 2

Call: PRELUDIUM 20 - announced on 2021-03-15

Amount awarded: 139 000 PLN

Project start date (Y-m-d): 2022-01-13

Project end date (Y-m-d): 2025-01-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (3)
  1. Accurate and sensitive interactome profiling using a quantitative protein-fragment complementation assay
    Authors:
    Natalia Lazarewicz, Gaelle Le Dez, Romina Cerjani, Lunelys Runeshaw, Matthias Meurer, Michael Knop, Robert Wysocki, Gwenael Rabut
    Academic press:
    Cell Reports: Methods (rok: 2024, tom: 4, strony: 46034), Wydawca: Elsevier Inc.
    Status:
    Published
    DOI:
    10.1016/j.crmeth.2024.100880 - link to the publication
  2. Multilevel Regulation of Membrane Proteins in Response to Metal and Metalloid Stress: A Lesson from Yeast
    Authors:
    Kacper Zbieralski , Jacek Staszewski , Julia Konczak , Natalia Lazarewicz , Malgorzata Nowicka-Kazmierczak , Donata Wawrzycka, Ewa Maciaszczyk-Dziubinska
    Academic press:
    International Journal of Molecular Sciences (rok: 2024, tom: 25, strony: 46052), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/ijms25084450 - link to the publication
  3. UPF1—From mRNA Degradation to Human Disorders
    Authors:
    Jacek Staszewski, Natalia Łazarewicz, Julia Kończak, Iwona Migdał, Ewa Maciaszczyk-Dziubinska
    Academic press:
    Cells (rok: 2023, tom: 12, strony: 46047), Wydawca: Mdpi
    Status:
    Published
    DOI:
    10.3390/cells12030419 - link to the publication