Projects funded by the NCN
The role of glycosyltransferase dimerization in Shiga toxins binding to glycosphingolipid- and glycoprotein-derived receptors.
2021/41/N/NZ6/00949
Keywords:
glycosyltransferase A4GALT B4GALT Shiga toxins
Descriptors:
- NZ6_008:
Panel:
NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution :
Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk
woj. dolnośląskie
Principal investigator (from the host institution):
dr Krzysztof Stefan Mikołajczyk
Number of co-investigators in the project: 2
Call: PRELUDIUM 20 - announced on 2021-03-15
Amount awarded: 209 718 PLN
Project start date (Y-m-d): 2022-01-20
Project end date (Y-m-d): 2025-01-19
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (3)
- Delving into human α1,4-galactosyltransferase acceptor specificity: The role of enzyme dimerization.Authors:Krzysztof Mikołajczyk, Karol Wróblewski, Sebastian KmiecikAcademic press:Biochemical and Biophysical Research Communications (rok: 2024, tom: 736, strony: 150486), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.bbrc.2024.150486 - link to the publication
- Gb3 trisaccharide-bearing exosomes as a novel neutralizer for Shiga toxin type 1Authors:Krzysztof MikołajczykAcademic press:Biochemical and Biophysical Research Communications (rok: 2024, tom: 739, strony: 150975), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.bbrc.2024.150975 - link to the publication
- B4GALT5-deficient CHO-Lec2 cells expressing human α1,4-galactosyltransferase: a glycoengineered cell model for studying Shiga toxin receptorsAuthors:Krzysztof MikołajczykAcademic press:Biochemical and Biophysical Research Communications (rok: 2025, tom: 754, strony: 151556), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.bbrc.2025.151556 - link to the publication