The role of glycosyltransferase dimerization in Shiga toxins binding to glycosph

The role of glycosyltransferase dimerization in Shiga toxins binding to glycosphingolipid- and glycoprotein-derived receptors.

2021/41/N/NZ6/00949

Keywords

Descriptors

NZ6_008: Inne zagadnienia pokrewne

Panel

NZ6 – Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda Polskiej Akademii Nauk

Voivodeship: dolnośląskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr Krzysztof Stefan Mikołajczyk

Number of co-investigators in the project: 2

Call

PRELUDIUM 20 – announced on 2021-03-15

Amount awarded: 209 718 PLN
Project start date: 2022-01-20
Project end date: 2025-01-19
Project duration: 36 months (the same as in the proposal)
Project status: Project settled

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (3)

B4GALT5-deficient CHO-Lec2 cells expressing human α1,4-galactosyltransferase: a glycoengineered cell model for studying Shiga toxin receptors

Authors:
Krzysztof Mikołajczyk

Academic press:
Biochemical and Biophysical Research Communications (year: 2025, volume: 754, pages: 151556), Publisher: Elsevier

Status:
Published

DOI:
10.1016/j.bbrc.2025.151556 – link to the publication
Delving into human α1,4-galactosyltransferase acceptor specificity: The role of enzyme dimerization.

Authors:
Krzysztof Mikołajczyk, Karol Wróblewski, Sebastian Kmiecik

Academic press:
Biochemical and Biophysical Research Communications (year: 2024, volume: 736, pages: 150486), Publisher: Elsevier

Status:
Published

DOI:
10.1016/j.bbrc.2024.150486 – link to the publication
Gb3 trisaccharide-bearing exosomes as a novel neutralizer for Shiga toxin type 1

Authors:
Krzysztof Mikołajczyk

Academic press:
Biochemical and Biophysical Research Communications (year: 2024, volume: 739, pages: 150975), Publisher: Elsevier

Status:
Published

DOI:
10.1016/j.bbrc.2024.150975 – link to the publication

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