Cooperative and collective phenomena in cell membrane adhesion

2021/40/Q/NZ1/00017

Keywords

Descriptors

  • NZ1_003: Biofizyka
  • ST4_004: Chemia teoretyczna i obliczeniowa
  • ST3_016: Fizyka układów biologicznych

Panel

NZ1 – Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution

Instytut Fizyki PAN

Voivodeship: mazowieckie

Other projects carried out by the institution »

Principal investigator (from the host institution)

dr hab. Bartosz Jan Różycki

Number of co-investigators in the project: 2

Call

SHENG 2 – announced on 2020-12-15

Amount awarded
395 280 PLN
Project start date
2022-03-01
Project end date
2026-08-31
Project duration
54 months (the same as in the proposal)
Project status
Pending project

Project description

Download the project description in a pdf file

Note — project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

Publication in academic press/journals (7)

  1. Mechanical forces impair antigen discrimination by reducing differences in T-cell receptor/peptide–MHC off-rates

    Authors:
    Johannes Pettmann, Lama Awada, Bartosz Różycki, Anna Huhn, Sara Faour, Mikhail Kutuzov, Laurent Limozin, Thomas R. Weikl, P. Anton van der Merwe, Philippe Robert, Omer Dushek
    Academic press:
    EMBO Journal (year: 2023, volume: 42, pages: e111841), Publisher: EMBO Press
    Status:
    Published
    DOI:
    10.15252/embj.2022111841 – link to the publication
  2. Interplay of receptor-ligand binding and lipid domain formation during cell adhesion

    Authors:
    Long Li, Jinglei Hu, Bartosz Różycki, Jing Ji, Fan Song
    Academic press:
    Frontiers in Molecular Biosciences (year: 2022, volume: 9, pages: 1019477), Publisher: Frontiers Media
    Status:
    Published
    DOI:
    10.3389/fmolb.2022.1019477 – link to the publication
  3. Control of cell membrane receptor condensation by adhesion to supported bilayers with nanoscale topography

    Authors:
    Long Li, Ruihan Hou, Xinghua Shi, Jing Ji, Bartosz Różycki, Jinglei Hu, Fan Song
    Academic press:
    Communications Physics (year: 2024, volume: 7, pages: 174), Publisher: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s42005-024-01670-1 – link to the publication
  4. Binding of soluble ligands to membrane receptors: a molecular dynamics simulation study

    Authors:
    Ruihan Hou, Jie Gao, Jingchun Chen, Rong Wang, Bartosz Różycki, Jinglei Hu
    Academic press:
    Journal of Physical Chemistry B (year: 2025, volume: 129, pages: 7475-7482), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jpcb.5c01197 – link to the publication
  5. Membrane-mediated cooperative interactions of CD47 and SIRPα

    Authors:
    Long Li, Chen Gui, Jinglei Hu, Bartosz Różycki
    Academic press:
    Membranes (year: 2023, volume: 13, pages: 871), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/membranes13110871 – link to the publication
  6. Multiscale simulations of membrane adhesion mediated by CD47-SIRPα complexes

    Authors:
    Ruihan Hou, Shuanglong Ren, Rong Wang, Bartosz Różycki, Jinglei Hu
    Academic press:
    Journal of Chemical Theory and Computation (year: 2025, volume: 21, pages: 2030-2042), Publisher: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acs.jctc.4c01337 – link to the publication
  7. Interplay between membrane adhesion and distribution of lipid rafts

    Authors:
    Iyad Bin Hussain Thalakodan, Bartosz Różycki
    Academic press:
    Surfaces (year: 2025, volume: 8, pages: 62), Publisher: MDPI
    Status:
    Published
    DOI:
    10.3390/surfaces8030062 – link to the publication

Book publications / chapters in book publications (2)

  1. Molecular Dynamics Simulations of Immune Receptors and Ligands

    Authors:
    Prithvi R. Pandey, Bartosz Różycki, Thomas R. Weikl
    Book:
    The Immune Synapse (year: 2023, volume: 2654, pages: 51-59), Publisher: Springer
    Status:
    Published
    DOI:
    10.1007/978-1-0716-3135-5_4 – link to the publication
  2. Lattice-based mesoscale simulations and mean-field theory of cell membrane adhesion

    Authors:
    Long Li, Jie Gao, Łukasz Milewski, Jinglei Hu, Bartosz Różycki
    Book:
    Methods in Enzymology (year: 2024, volume: 701, pages: 425-455), Publisher: Academic Press
    Status:
    Published
    DOI:
    10.1016/bs.mie.2024.03.005 – link to the publication

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Graphic design and implementation: Jakub Piotrowski