Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Tryptophan Metabolites and their Metal Complexes as new drugs for Colorectal Cancer Treatment and Human Gut Microbiota Regulation

2020/39/B/ST4/03060

Keywords:

Tryptophan metabolism Chemical speciation Solution chemistry Metal complexes Human gut microbiota

Descriptors:

  • ST4_011:
  • ST4_009:
  • ST4_017:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet w Białymstoku, Wydział Chemii

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Beata Izabella Godlewska-Żyłkiewicz 

Number of co-investigators in the project: 6

Call: OPUS 20 - announced on 2020-09-15

Amount awarded: 1 838 780 PLN

Project start date (Y-m-d): 2021-10-01

Project end date (Y-m-d): 2025-09-30

Project duration:: 48 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. The accurate assessment of the chemical speciation of complex systems through multi-technique approaches
    Authors:
    Anna Baryłka, Beata Godlewska-Żyłkiewicz, Demetrio Milea, Sofia Gama
    Academic press:
    Pure and Applied Chemistry (rok: 2024, tom: 96, strony: 597-623), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.1515/pac-2024-0206 - link to the publication
  2. Ga complexes of 8-hydroxyquinoline-2-carboxylic acid: Chemical speciation and biological activity
    Authors:
    Izabela Ryza, Claudia Granata, Nadia Ribeiro, Edyta Nalewajko-Sieliwoniuk, Andreas Kießling, Marta Hryniewicka, Winfried Plass, Beata Godlewska-Żyłkiewicz, Sandra Cabo Verde, Demetrio Milea, Sofia Gama
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2024, tom: 260, strony: 112670), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2024.112670 - link to the publication
  3. Acid-base properties of hydroxyquinolines in aqueous solution: effect of hydroxyl group position on thermodynamic protonation parameters
    Authors:
    Anna Baryłka, Giuseppina D.G. Santonoceta, Giuseppe Gattuso, Beata Godlewska-Żyłkiewicz, Carmelo Sgarlata, Demetrio Milea, Sofia Gama
    Academic press:
    Journal of Molecular Liquids (rok: 2025, tom: 417, strony: 126671), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molliq.2024.126671 - link to the publication
  4. Protonation equilibria of the tryptophan metabolite 8-hydroxyquinoline- 2-carboxylic acid (8-HQA) and its precursors: A potentiometric and calorimetric comparative study
    Authors:
    Anna Baryłka, Aneta Bagińska-Krakówka, Lidia Zuccarello, Francesca Mancuso, Giuseppe Gattuso, Gabriele Lando, Carmelo Sgarlata, Concetta De Stefano, Beata Godlewska-Żyłkiewicz, Demetrio Milea, Sofia Gama
    Academic press:
    Thermochimica Acta (rok: 2023, tom: 730, strony: 179615), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.sab.2020.105922 - link to the publication
  5. Protonation equilibria of the tryptophan metabolite 8-hydroxyquinoline- 2-carboxylic acid (8-HQA) and its precursors: A potentiometric and calorimetric comparative study
    Authors:
    Anna Baryłka, Aneta Bagińska-Krakówka, Lidia Zuccarello, Francesca Mancuso, Giuseppe Gattuso, Gabriele Lando, Carmelo Sgarlata, Concetta De Stefano, Beata Godlewska-Żyłkiewicz, Demetrio Milea, Sofia Gama
    Academic press:
    Thermochimica Acta (rok: 2023, tom: 730, strony: 179615), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.sab.2020.105922 - link to the publication

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