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The role of heat shock protein 90 in atopic dermatitis

2020/39/B/NZ6/00357

Keywords:

Atopic dermatitis heat shock proteins Hsp90

Descriptors:

  • NZ6_001:

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Gdański, Wydział Biologii

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Stefan Zbigniew Tukaj 

Number of co-investigators in the project: 2

Call: OPUS 20 - announced on 2020-09-15

Amount awarded: 1 022 800 PLN

Project start date (Y-m-d): 2021-06-11

Project end date (Y-m-d): 2025-06-10

Project duration:: 48 months (the same as in the proposal)

Project status: Project completed

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (1)
  1. Altered Gene Expression of IL-35 and IL-36α in the Skin of Patients with Atopic Dermatitis
    Authors:
    Weronika Zysk, Krzysztof Sitko, Stefan Tukaj, Anna Zaryczańska, Magdalena Trzeciak
    Academic press:
    Int J Mol Sci (rok: 2023, tom: 25(1), strony: 404), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms25010404 - link to the publication
  2. Dual role of autoantibodies to heat shock proteins in autoimmune diseases
    Authors:
    Stefan Tukaj
    Academic press:
    Frontiers in Immunology (rok: 2024, tom: 15, strony: 1421528), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2024.1421528 - link to the publication
  3. Case Report: Circulating Anti-SARS-CoV-2 Antibodies Do Not Cross-React With Pemphigus or Pemphigoid Autoantigens
    Authors:
    Michael Kasperkiewicz, Marta Bednarek, Stefan Tukaj
    Academic press:
    Frontiers in Medicine (rok: 2021, tom: 8, strony: 807711), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmed.2021.807711 - link to the publication
  4. Detection of autoantibodies to heat shock protein 70 in the saliva and urine of normal individuals
    Authors:
    Krzysztof Sitko, Jagoda Mantej, Marta Bednarek, Stefan Tukaj
    Academic press:
    Frontiers in Immunology (rok: 2024, tom: 15, strony: 1454018), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2024.1454018 - link to the publication
  5. Heat Shock Protein 90 (Hsp90) and Hsp70 as Potential Therapeutic Targets in Autoimmune Skin Diseases
    Authors:
    Stefan Tukaj, Krzysztof Sitko
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 1153), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12081153 - link to the publication
  6. Targeting heat shock proteins 90 and 70: A promising remedy for both autoimmune bullous diseases and COVID-19
    Authors:
    Michael Kasperkiewicz, Stefan Tukaj
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 1080786), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.1080786 - link to the publication
  7. Circulating heat shock protein 90 (Hsp90) in atopic dermatitis and bullous pemphigoid: is there a link?
    Authors:
    Stefan Tukaj
    Academic press:
    Cell Stress and Chaperones (rok: 2022, tom: 27, strony: 601–602), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12192-022-01298-6 - link to the publication
  8. Differences in the detection of circulating Hsp90 alpha between patients with atopic dermatitis and dermatitis herpetiformis
    Authors:
    Krzysztof Sitko, Sarolta Kárpáti, Grzegorz Węgrzyn, Grzegorz Mincewicz, Magdalena Trzeciak, Michael Kasperkiewicz, Stefan Tukaj
    Academic press:
    Frontiers in Medicine (rok: 2024, tom: 10, strony: 1327144), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmed.2023.1327144 - link to the publication
  9. Heat shock protein 90 (Hsp90) inhibitor STA-9090 (Ganetespib) ameliorates inflammation in a mouse model of atopic dermatitis
    Authors:
    Krzysztof Sitko, Michał Starke, Stefan Tukaj
    Academic press:
    Cell Stress Chaperones (rok: 2023, tom: 28(6), strony: 935–942), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12192-023-01387-0 - link to the publication
  10. Pathological Relevance of Anti-Hsp70 IgG Autoantibodies in Epidermolysis Bullosa Acquisita
    Authors:
    Stefan Tukaj, Jagoda Mantej, Krzysztof Sitko, Detlef Zillikens, Ralf J. Ludwig, Katja Bieber, Michael Kasperkiewicz
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 877958), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.877958 - link to the publication
  11. Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis
    Authors:
    Krzysztof Sitko, Marta Bednarek, Jagoda Mantej, Magdalena Trzeciak, Stefan Tukaj
    Academic press:
    Cell Stress and Chaperones (rok: 2021, tom: 26, strony: 1001–1007), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12192-021-01238-w - link to the publication
  12. Heat shock protein 90 (Hsp90) inhibitor STA-9090 (Ganetespib) ameliorates inflammation in a mouse model of atopic dermatitis
    Authors:
    Krzysztof Sitko, Michał Starke, Stefan Tukaj
    Academic press:
    Cell Stress Chaperones (rok: 2023, tom: 28(6), strony: 935–942), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12192-023-01387-0 - link to the publication
  13. Targeting heat shock proteins 90 and 70: A promising remedy for both autoimmune bullous diseases and COVID-19
    Authors:
    Michael Kasperkiewicz, Stefan Tukaj
    Academic press:
    Frontiers in Immunology (rok: 2022, tom: 13, strony: 1080786), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fimmu.2022.1080786 - link to the publication
  14. Circulating heat shock protein 90 (Hsp90) and autoantibodies to Hsp90 are increased in patients with atopic dermatitis
    Authors:
    Krzysztof Sitko, Marta Bednarek, Jagoda Mantej, Magdalena Trzeciak, Stefan Tukaj
    Academic press:
    Cell Stress and Chaperones (rok: 2021, tom: 26, strony: 1001–1007), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12192-021-01238-w - link to the publication
  1. Topically applied Hsp90 inhibitor 17-AAG ameliorates skin inflammation in a mouse model of atopic dermatitis
    Authors:
    Krzysztof Sitko, Michal Starke, Stefan Tukaj
    Conference:
    Innate Immunity and Inflammation/Journal of Investigative Dermatology (rok: 2024, tom: 53rd ESDR Annual Meeting 2024, strony: S278), Wydawca: Elsevier
    Data:
    konferencja 4 to 7 September 2024
    Status:
    Published
    DOI:
    10.298 - link to the publication

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