Projects funded by the NCN
A controlled post-polymerization modification method and its application for construction of macromolecular membrane-lytic agents
2020/39/B/ST4/00183
Keywords:
post-polymerization modification ionenes antibacterial polymers saccharide-polymer conjugates controlled polymer modification
Descriptors:
- ST4_010:
- ST4_009:
- NZ6_004:
Panel:
ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development
Host institution :
Politechnika Warszawska
woj. mazowieckie
Principal investigator (from the host institution):
dr hab. Dominik Jerzy Jańczewski
Number of co-investigators in the project: 8
Call: OPUS 20 - announced on 2020-09-15
Amount awarded: 2 096 220 PLN
Project start date (Y-m-d): 2021-09-15
Project end date (Y-m-d): 2025-09-14
Project duration:: 48 months (the same as in the proposal)
Project status: Project completed
Project description
Download the project description in a pdf file
Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.
Information in the final report
- Publication in academic press/journals (2)
- Polytrimethylenimines: Highly Potent Antibacterial Agents with Activity and Toxicity Modulated by the Polymer Molecular WeightAuthors:Julita Pachla, Rafał J. Kopiasz, Gabriela Marek, Waldemar Tomaszewski, Agnieszka Głogowska, Karolina Drężek, Sebastian Kowalczyk, Rafał Podgórski, Beata Butruk-Raszeja, Tomasz Ciach, Jolanta Mierzejewska, Andrzej Plichta, Ewa Augustynowicz-Kopeć, Dominik JańczewskiAcademic press:Biomacromolecules (rok: 2023, tom: 24, strony: 2237–2249), Wydawca: ACSStatus:PublishedDOI:10.1021/acs.biomac.3c00139 - link to the publication
- Membrane lytic activity of antibacterial ionenes, critical role of phosphatidylcholine (PC) and cardiolipin (CL)Authors:Dominika Kozon-Markiewicz, Rafał J. Kopiasz, Martyna Głusiec, Agnieszka Łukasiak, Piotr Bednarczyk, Dominik JańczewskiAcademic press:Colloids and Surfaces B: Biointerfaces (rok: 2023, tom: 229, strony: 113480), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.colsurfb.2023.113480 - link to the publication