Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Structural and functional studies of engineered and chimeric plant-type asparaginases as novel antileukemics

2020/38/E/NZ1/00035

Keywords:

asparaginaza białaczka inżynieria białek białek fuzyjne (chimery) zależność struktura-funkcja

Descriptors:

  • NZ1_001:
  • NZ1_005:
  • NZ1_004:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Joanna Izabela Loch 

Number of co-investigators in the project: 6

Call: SONATA BIS 10 - announced on 2020-07-29

Amount awarded: 1 998 776 PLN

Project start date (Y-m-d): 2021-04-01

Project end date (Y-m-d): 2026-03-31

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (8)
  1. Towards a dependable data set of structures for L-asparaginase research
    Authors:
    Alexandr Wlodawer, Zbigniew Dauter, Jacek Lubkowski, Joanna Loch, Dariusz Brzezinski, Mirosław Gilski, Mariusz Jaskolski
    Academic press:
    Acta Crystallographica Section D (rok: 2024, tom: D80, strony: 506-527), Wydawca: International Union of Crystallography (co-published with Wiley)
    Status:
    Published
    DOI:
    10.1107/S2059798324005461 - link to the publication
  2. Probing the enzymatic activity and maturation process of the EcAIII Ntn-amidohydrolase using local random mutagenesis
    Authors:
    Joanna Loch, Anna Ściuk, Marta Kilichowska, Izabela Pieróg, Weronika Łukaszczyk, Katarzyna Zimowska, Mariusz Jaskolski
    Academic press:
    Acta Biochimica Polonica (rok: 2024, tom: 17, strony: 12299), Wydawca: Frontiers Media S.A./Polish Biochemical Society
    Status:
    Published
    DOI:
    10.3389/abp.2024.12299 - link to the publication
  3. Structural and biophysical aspects of L-asparaginases: a growing family with amazing diversity
    Authors:
    Joanna Loch, Mariusz Jaskólski
    Academic press:
    IUCrJ (rok: 2021, tom: 8, strony: 514-531), Wydawca: International Union of Crystallography (IUCr)
    Status:
    Published
    DOI:
    10.1107/S2052252521006011 - link to the publication
  4. Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes
    Authors:
    Anna Ściuk, Kinga Wątor, Izabela Staroń, Paulina Worsztynowicz, Kinga Pokrywka, Joanna Sliwiak, Marta Kilichowska, Kamila Pietruszewska, Zofia Mazurek, Anna Skalniak, Krzysztof Lewandowski, Mariusz Jaskolski, Joanna Loch, Marcin Surmiak
    Academic press:
    Molecules (rok: 2024, tom: 29, strony: 2272), Wydawca: MDPI AG Switzerland
    Status:
    Published
    DOI:
    10.3390/molecules29102272 - link to the publication
  5. Structural and biophysical studies of new L-asparaginase variants: lessons from random mutagenesis of the prototypic Escherichia coli Ntn-amidohydrolase
    Authors:
    Joanna I. Loch, Agnieszka Klonecka, Kinga Kądziołka, Piotr Bonarek, Jakub Barciszewski, Barbara Imiolczyk, Krzysztof Brzezinski, Mirosław Gilski, Mariusz Jaskolski
    Academic press:
    Acta Crystallographica D Structural Biology (rok: 2022, tom: 78, strony: 911–926), Wydawca: International Union of Crystallography
    Status:
    Published
    DOI:
    10.1107/S2059798322005691 - link to the publication
  6. Massive annotation of bacterial L-asparaginases reveals their puzzling distribution and frequent gene transfer events
    Authors:
    Andrzej Zielezinski, Joanna Loch, Wojciech Karlowski, Mariusz Jaskolski
    Academic press:
    Scientific Reports (rok: 2022, tom: 12, strony: 15797), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-022-19689-1 - link to the publication
  7. The effects of nature-inspired amino acid substitutions on structural and biochemical properties of the E. coli L-asparaginase EcAIII
    Authors:
    Maciej Janicki , Anna Ściuk, Andrzej Zielezinski, Milosz Ruszkowski, Agnieszka Ludwików, Wojciech M. Karłowski, Mariusz Jaskólski, Joanna Loch
    Academic press:
    Protein Science (rok: 2023, tom: 32, strony: e4647), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/pro.4647 - link to the publication
  8. The effects of nature-inspired amino acid substitutions on structural and biochemical properties of the E. coli L-asparaginase EcAIII
    Authors:
    Maciej Janicki , Anna Ściuk, Andrzej Zielezinski, Milosz Ruszkowski, Agnieszka Ludwików, Wojciech M. Karłowski, Mariusz Jaskólski, Joanna Loch
    Academic press:
    Protein Science (), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/pro.4647 - link to the publication

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