Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

A tissue engineering platform for precision cancer medicine and chemosensitivity testing in head and neck squamous cell carcinoma

2020/37/B/NZ4/03920

Keywords:

head and neck cancer oral cancer head and neck squamous cell carcinoma HNSCC personalized medicine precision medicine in vitro testing chemosensitivity testing tissue engineering 3D models microtissues vascularization extracellular matrix ECM tumour environment

Descriptors:

  • NZ4_004:

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Medyczny w Lublinie

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Matthias Nees 

Number of co-investigators in the project: 4

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 1 698 720 PLN

Project start date (Y-m-d): 2021-03-02

Project end date (Y-m-d): 2025-11-01

Project duration:: 56 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (5)
  1. Shooting at Moving and Hidden Targets-Tumour Cell Plasticity and the Notch Signalling Pathway in Head and Neck Squamous Cell Carcinomas
    Authors:
    Joanna Kałafut, Arkadiusz Czerwonka, Alinda Anameriç, Alicja Przybyszewska-Podstawka, Julia O Misiorek, Adolfo Rivero-Müller, Matthias Nees
    Academic press:
    Cancwrs (rok: 2021, tom: 13 (24), strony: 57), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers13246219 - link to the publication
  2. Modulation of Notch Signaling by Small-Molecular Compounds and Its Potential in Anticancer Studies
    Authors:
    Arkadiusz Czerwonka, Joanna Kałafut, Matthias Nees
    Academic press:
    Cancers (rok: 2023, tom: 15 (8), strony: 4563f), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.1038/s41598-023-39472-0 - link to the publication
  3. Evaluation of the anticancer activity of RIN-1, a Notch signaling modulator, in head and neck squamous cell carcinoma
    Authors:
    Arkadiusz Czerwonka, Joanna Kałafut, Shaoxia Wang, Alinda Anameric, Alicja Przybyszewska-Podstawka, Jesse Mattsson, Mahtab Karbasian, Doriane Le Manach, Mervi Toriseva, Matthias Nees
    Academic press:
    Scientific Reports (rok: 2023, tom: 13 (1), strony: 13700f), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-023-39472-0 - link to the publication
  4. The Notch inhibitor, FLI-06, increases the chemosensitivity of head and neck Squamous cell carcinoma cells to taxanes-based treatment
    Authors:
    Arkadiusz Czerwonka, Joanna Kałafut, Shaoxia Wang, Alinda Anameric, Alicja Przybyszewska-Podstawka, Mervi Toriseva , Matthias Nees
    Academic press:
    Biomedicine & Pharmacotherapy (rok: 2024, tom: 177, strony: 116822), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biopha.2024.116822 - link to the publication
  5. Optimization of a Three-Dimensional Culturing Method for Assessing the Impact of Cisplatin on Notch Signaling in Head and Neck Squamous Cell Carcinoma (HNSCC)
    Authors:
    Alinda Anameriç, Arkadiusz Czerwonka, Matthias Nees
    Academic press:
    Cancers (rok: 2023, tom: 15 (22), strony: 5320f), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/cancers15225320 - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy