Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Making use of siderophore transport systems to deliver peptide nucleic acids to bacterial cells

2020/37/B/NZ1/02904

Keywords:

oligonucleotides peptide nucleic acids (PNA) bacterial uptake systems iron transport siderophores TonB-dependent outer-membrane receptors Gram-negative bacteria symulacje dynamiki molekularnej

Descriptors:

  • NZ1_002:
  • NZ2_007:
  • NZ1_001:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Joanna Dominika Trylska 

Number of co-investigators in the project: 5

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 2 220 720 PLN

Project start date (Y-m-d): 2021-02-01

Project end date (Y-m-d): 2026-01-31

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

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Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (6)
  • Articles in post-conference publications (1)
  1. Highly phosphorescent N^C^N platinum(II)-peptide nucleic acid conjugates: synthesis, photophysical studies and hybridization behaviour
    Authors:
    Rosa Maria Dell'Acqua, Francesco Fagnani, Monika Wojciechowska, Daniele Marinotto, Graziano Colombo, Isabella Dalle-Donne, Joanna Trylska, Silvia Cauteruccio, Alessia Colombo
    Academic press:
    Dalton Transactions (rok: 2025, tom: 54, strony: 3314-3322), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/D4DT03366C - link to the publication
  2. Structural dynamics influences the antibacterial activity of a cell-penetrating peptide (KFF)3K
    Authors:
    Julia Macyszyn, Piotr Chyży, Michał Burmistrz, Małgorzata Lobka, Joanna Miszkiewicz, Monika Wojciechowska, Joanna Trylska
    Academic press:
    Scientific Reports (rok: 2023, tom: 13, strony: 14826), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-38745-y - link to the publication
  3. Peptide nucleic acid conjugates and their antimicrobial applications—a mini‐review
    Authors:
    Uladzislava Tsylents, Izabela Siekierska, Joanna Trylska
    Academic press:
    European Biophysics Journal (rok: 2023, tom: 52, strony: 533–544), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00249-023-01673-w - link to the publication
  4. Iron uptake pathway of Escherichia coli as an entry route for peptide nucleic acids conjugated with a siderophore mimic
    Authors:
    Uladzislava Tsylents, Michał Burmistrz, Monika Wojciechowska, Jan Stępień, Piotr Maj, Joanna Trylska
    Academic press:
    Frontiers in Microbiology (rok: 2024, tom: 15, strony: 1331021), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2024.1331021 - link to the publication
  5. Design, synthesis and evaluation of lysine- and leucine-rich hydrocarbon-stapled peptides as antibacterial agents
    Authors:
    Małgorzata Lobka, Izabela Siekierska, Piotr Chyży, Michał Burmistrz, Julia Macyszyn, Renata Grzela, Monika Wojciechowska, Joanna Trylska
    Academic press:
    European Journal of Medicinal Chemistry (rok: 2025, tom: 290, strony: 117445), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejmech.2025.117445 - link to the publication
  6. Conjugates of Aminoglycosides with Stapled Peptides as a Way to Target Antibiotic-Resistant Bacteria
    Authors:
    Julia Macyszyn, Michał Burmistrz, Adam Mieczkowski, Monika Wojciechowska, Joanna Trylska
    Academic press:
    ACS Omega (rok: 2023, tom: 8, strony: 19047−19056), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsomega.3c02071 - link to the publication
  1. The ornithine-based siderophore as a potential carrier of peptide nucleic acid into Escherichia coli cells
    Authors:
    Uladzislava Tsylents, Michał Burmistrz, Piotr Maj, Monika Wojciechowska, Joanna Trylska
    Conference:
    Proceedings of the 37th European and the 14th International Peptide Symposium (rok: 2024, tom: 37th European and the 14th International Peptide Symposium, Florence, Italy, 25-31 August 2024, strony: P1260), Wydawca: European Peptide Society
    Data:
    konferencja 25-29.08.2024
    Status:
    Published
    DOI:
    10.17952/37EPS.2024.P1260 - link to the publication

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