Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Making use of siderophore transport systems to deliver peptide nucleic acids to bacterial cells

2020/37/B/NZ1/02904

Keywords:

oligonucleotides peptide nucleic acids (PNA) bacterial uptake systems iron transport siderophores TonB-dependent outer-membrane receptors Gram-negative bacteria symulacje dynamiki molekularnej

Descriptors:

  • NZ1_002:
  • NZ2_007:
  • NZ1_001:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Joanna Dominika Trylska 

Number of co-investigators in the project: 5

Call: OPUS 19 - announced on 2020-03-16

Amount awarded: 2 220 720 PLN

Project start date (Y-m-d): 2021-02-01

Project end date (Y-m-d): 2026-01-31

Project duration:: 60 months (the same as in the proposal)

Project status: Pending project

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Structural dynamics influences the antibacterial activity of a cell-penetrating peptide (KFF)3K
    Authors:
    Julia Macyszyn, Piotr Chyży, Michał Burmistrz, Małgorzata Lobka, Joanna Miszkiewicz, Monika Wojciechowska, Joanna Trylska
    Academic press:
    Scientific Reports , Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41598-023-38745-y - link to the publication
  2. Peptide nucleic acid conjugates and their antimicrobial applications—a mini‐review
    Authors:
    Uladzislava Tsylents, Izabela Siekierska, Joanna Trylska
    Academic press:
    European Biophysics Journal (), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1007/s00249-023-01673-w - link to the publication
  3. Conjugates of Aminoglycosides with Stapled Peptides as a Way to Target Antibiotic-Resistant Bacteria
    Authors:
    Julia Macyszyn, Michał Burmistrz, Adam Mieczkowski, Monika Wojciechowska, Joanna Trylska
    Academic press:
    ACS Omega (), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/acsomega.3c02071 - link to the publication
  4. Iron uptake pathway of Escherichia coli as an entry route for peptide nucleic acids conjugated with a siderophore mimic
    Authors:
    Uladzislava Tsylents, Michał Burmistrz, Monika Wojciechowska, Jan Stępień, Piotr Maj, Joanna Trylska
    Academic press:
    Frontiers in Microbiology , Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fmicb.2024.1331021 - link to the publication

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