Projects funded by the NCN

Information on the principal investigator and host institution

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Assessment of the ability of application of folic acid and/or transferrin as alinkers between conjugates of quantum dots with unsymmetricalbisacridines to enhance their selectivity and cytotoxicity against lung andprostate cancer cells.

2020/37/N/NZ7/01979

Keywords:

antitumor unsymmetrical bisacridines (UAs) quantum dots (QDs) nanoconjugates QD-TM-UAs cytotoxicity cellular response cellular uptake drug delivery.

Descriptors:

  • NZ7_014:
  • NZ3_001:
  • NZ7_015:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Politechnika Gdańska

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Joanna Pilch 

Number of co-investigators in the project: 2

Call: PRELUDIUM 19 - announced on 2020-03-16

Amount awarded: 139 998 PLN

Project start date (Y-m-d): 2021-01-14

Project end date (Y-m-d): 2023-01-13

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (4)
  1. Foliate-Targeting Quantum Dots–β–Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
    Authors:
    Joanna Pilch, Patrycja Kowalik, Agata Kowalczyk, Piotr Bujak, Artur Kasprzak, Ewa Paluszkiewicz, Ewa Augustin, Anna M. Nowicka
    Academic press:
    International Journal of Molecular Sciences
    Status:
    Submitted
  2. Foliate-Targeting Quantum Dots–β–Cyclodextrin Nanocarrier for Efficient Delivery of Unsymmetrical Bisacridines to Lung and Prostate Cancer Cells
    Authors:
    Joanna Pilch, Patrycja Kowalik, Agata Kowalczyk, Piotr Bujak, Artur Kasprzak, Ewa Paluszkiewicz, Ewa Augustin, Anna M. Nowicka
    Academic press:
    International Journal of Molecular Sciences (rok: 2022, tom: 23, strony: 1261), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms23031261 - link to the publication
  3. pH-Responsive Drug Delivery Nanoplatforms as Smart Carriers of Unsymmetrical Bisacridines for Targeted Cancer Therapy
    Authors:
    Pilch J., Potęga A., Kowalczyk A., Kasprzak A., Kowalik P., Bujak P., Paluszkiewicz E., Augustin E., Nowicka A.M.
    Academic press:
    Pharmaceutics (rok: 2023, tom: 15, strony: 45677), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/pharmaceutics15010201 - link to the publication
  4. Nanocząstki w chemioterapii: charakterystyka, strategie projektowania, mechanizm wnikania oraz degradacja wewnątrzkomórkowa
    Authors:
    Joanna Pilch
    Academic press:
    Postępy biochemii (rok: 2022, tom: 68, strony: 196-208), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    10.18388/pb.2021_441. - link to the publication

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