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Information of the project and the call

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A peptidomimetic strategy to improve the antimicrobial properties of calcitermin

2020/37/N/ST4/03165

Keywords:

copper zinc calcitermin peptidomimetics antimicrobial peptides metal coordination

Descriptors:

  • ST4_009:
  • ST4_005:
  • ST4_011:

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Denise Bellotti 

Number of co-investigators in the project: 2

Call: PRELUDIUM 19 - announced on 2020-03-16

Amount awarded: 192 000 PLN

Project start date (Y-m-d): 2021-02-03

Project end date (Y-m-d): 2024-02-02

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Project description

Download the project description in a pdf file

Note - project descriptions were prepared by the authors of the applications themselves and placed in the system in an unchanged form.

Information in the final report

  • Publication in academic press/journals (10)
  • Articles in post-conference publications (22)
  • Book publications / chapters in book publications (1)
  1. Calcitermin-Loaded Smart Gels Activity against Candida albicans: A Preliminary In Vitro Study
    Authors:
    Denise Bellotti, Maria D'Accolti, Walter Pula, Nicolas Huang, Fanny Simeliere, Elisabetta Caselli, Elisabetta Esposito, Maurizio Remelli
    Academic press:
    Gels (rok: 2023, tom: 9, strony: 165), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  2. Zn2+ and Cu2+ binding to the extramembrane loop of Zrt2, a zinc transporter from Candida albicans
    Authors:
    Denise Bellotti,* Adriana Miller, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 121), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12010121 - link to the publication
  3. Metal coordination governs the antimicrobial efficacy of calcitermin derivatives
    Authors:
    Silvia Leveraro, Kinga Garstka, Paulina Śliwka, Tomasz Janek, Magdalena Rowińska-Żyrek, Maurizio Remelli, Denise Bellotti
    Academic press:
    Dalton transactions (rok: 2024, ), Wydawca: Royal Society of Chemistry
    Status:
    Submitted
  4. Impact of C- and N-terminal protection on the stability, metal chelation and antimicrobial properties of calcitermin
    Authors:
    Maria D'Accolti, Denise Bellotti, Emilia Dzień, Carlotta Leonetti, Silvia Leveraro, Valentina Albanese, Erika Marzola, Remo Guerrini, Elisabetta Caselli, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Academic press:
    Scientific reports (rok: 2023, tom: 13, strony: 18228), Wydawca: Nature Portfolio
    Status:
    Published
    DOI:
    10.1038/s41598-023-45437-0 - link to the publication
  5. Lights and Shadows on the Therapeutic Use of Antimicrobial Peptides
    Authors:
    Denise Bellotti, Maurizio Remelli
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 4584), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  6. Calcitermin-Loaded Smart Gels Activity against Candida albicans: A Preliminary In Vitro Study
    Authors:
    Denise Bellotti, Maria D'Accolti, Walter Pula, Nicolas Huang, Fanny Simeliere, Elisabetta Caselli, Elisabetta Esposito, Maurizio Remelli
    Academic press:
    Gels (rok: 2023, tom: 9, strony: 165), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  7. Investigation of metal interactions with YrpE protein of Bacillus subtilis by a polyhistidine peptide model
    Authors:
    Denise Bellotti, Silvia Leveraro, Aleksandra Hecel, Maurizio Remelli
    Academic press:
    Analytical Biochemistry (rok: 2023, tom: 680, strony: 115315), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ab.2023.115315 - link to the publication
  8. Zn2+ and Cu2+ binding to the extramembrane loop of Zrt2, a zinc transporter from Candida albicans
    Authors:
    Denise Bellotti,* Adriana Miller, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 121), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12010121 - link to the publication
  9. Zn2+ and Cu2+ binding to the extramembrane loop of Zrt2, a zinc transporter from Candida albicans
    Authors:
    Denise Bellotti,* Adriana Miller, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Academic press:
    Biomolecules (rok: 2022, tom: 12, strony: 121), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/biom12010121 - link to the publication
  10. Lights and Shadows on the Therapeutic Use of Antimicrobial Peptides
    Authors:
    Denise Bellotti, Maurizio Remelli
    Academic press:
    Molecules (rok: 2022, tom: 27, strony: 4584), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ - link to the publication
  1. From biological systems to metal binding tools: the case of polyhistidine peptides
    Authors:
    Denise BELLOTTI, Silvia Leveraro, Aleksandra Hecel, Maurizio Remelli
    Conference:
    Book of Abstract of the 4th European NECTAR Conference and Final Action Meeting (rok: 2024, tom: 4th European NECTAR Conference and Final Action Meeting, strony: P03), Wydawca: Demetrio Milea, Sofia Gama
    Data:
    konferencja 26-27 February 2024
    Status:
    Published
    DOI:
    - - link to the publication
  2. Understanding the mechanism of ZinT-mediated metal acquisition: a thermodynamic study
    Authors:
    Denise Bellotti,* Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Acta of the International Symposia on Thermodynamics of Metal Complexes XXXI Edition (rok: 2021, tom: ISMEC 2021, strony: 176-177), Wydawca: Demetrio Milea, Sofia Gama
    Data:
    konferencja 16-18 June 2021
    Status:
    Published
  3. Calcitermin and its derivatives: novel insights into the antimicrobial activity of metal-binding peptides
    Authors:
    Denise Bellotti, Maria D'Accolti, Elisabetta Caselli, Maurizio Remelli, Magdalena Rowińska-Żyrek
    Conference:
    Book of Abstract of the 10th International Meeting on Antimicrobial Peptides (rok: 2023, tom: 10th International Meeting on Antimicrobial Peptides, strony: 10), Wydawca: University of Trieste
    Data:
    konferencja 06-08 September 2023
    Status:
    Published
    DOI:
    - - link to the publication
  4. The effect of Ala-to-Ser substitution on calcitermin derivatives
    Authors:
    Silvia Leveraro, Denise Bellotti, Magdalena Rowińska-Żyrek, Remo Guerrini, Maurizio Remelli
    Conference:
    Acta of the International Symposia on Metal Complexes (rok: 2023, tom: International Symposia on Metal Complexes 2023, strony: 132-133), Wydawca: ISMEC GROUP
    Data:
    konferencja 11-14 June 2023
    Status:
    Published
    DOI:
    - - link to the publication
  5. The impact of metal coordination on calcitermin antimicrobial properties
    Authors:
    Denise Bellotti,* Silvia Leveraro, Emilia Dzień, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Atti del XXIX Congresso della Divisione di Chimica Analitica della Società Chimica Italiana (rok: 2022, tom: XXIX Conference of the Analytical Chemistry Division of the Italian Chemical Society, strony: 145), Wydawca: Società Chimica Italiana
    Data:
    konferencja 11-15 September 2022
    Status:
    Published
    DOI:
    - - link to the publication
  6. Understanding the effect of amino- and carboxyl-terminal protection on the stability and metal chelation properties of the antimicrobial peptide calcitermin
    Authors:
    Denise Bellotti,* Emilia Dzień, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    International Conference on Metal-Binding Peptides: Methodologies and Applications, I Edition (rok: 2022, tom: 1st International Conference on Metal-Binding Peptides: Methodologies and Applications, strony: 144), Wydawca: Peter Faller, Laetitia Canabady-Rochelle
    Data:
    konferencja 5-8 July 2022
    Status:
    Published
    DOI:
    - - link to the publication
  7. Understanding the effect of amino- and carboxyl-terminal protection on the stability and metal chelation properties of the antimicrobial peptide calcitermin
    Authors:
    Denise Bellotti,* Emilia Dzień, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    International Conference on Metal-Binding Peptides: Methodologies and Applications, I Edition (rok: 2022, tom: 1st International Conference on Metal-Binding Peptides: Methodologies and Applications, strony: 144), Wydawca: Peter Faller, Laetitia Canabady-Rochelle
    Data:
    konferencja 5-8 July 2022
    Status:
    Published
    DOI:
    - - link to the publication
  8. The importance of being positive! Ala-to-Arg substitution in the antimicrobial peptide calcitermin
    Authors:
    Silvia Leveraro, Denise Bellotti, Magdalena Rowińska-Žyrek, Remo Guerrini, Maurizio Remelli
    Conference:
    XXII Giornata della Chimica dell'Emilia-Romagna, Chimica e Salute (rok: 2023, tom: XXII Giornata della Chimica dell'Emilia-Romagna, Chimica e Salute, strony: 41), Wydawca: Italian Chemical Society
    Data:
    konferencja 45278
    Status:
    Published
    DOI:
    - - link to the publication
  9. Understanding the thermodynamics and coordination chemistry of metal-binding proteins: the common thread to elucidate metal acquisition processes at host/pathogen interface
    Authors:
    Denise Bellotti,* Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    BOOK OF ABSTRACTS XXVII congresso della SCI 2021, La chimica guida lo sviluppo sostenibile (rok: 2021, tom: XXVII Congresso della SCI, strony: 321), Wydawca: Società Chimica Italiana
    Data:
    konferencja 14-23 September 2021
    Status:
    Published
  10. Unravelling the antimicrobial properties of calcitermin and its peptide derivatives
    Authors:
    Denise Bellotti,* Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Proceedings of the Merck Young Chemists' Symposium XX Edition (rok: 2021, tom: MYCS 2021, strony: 115), Wydawca: G. Annunziato, M. Atzori, C. Bonfio, S. Cinti, B. Coppola, M. Da Pian, C. Imparato, V. Lazazzara, E. Lenci, A. Malara, D. Morselli, E. Paone, F. Ponte, S. Rebeccani, L. Rivoira, M. Schlich
    Data:
    konferencja 22-24 November 2021
    Status:
    Published
  11. Understanding the thermodynamics and coordination chemistry of metal-binding proteins: the common thread to elucidate metal acquisition processes at host/pathogen interface
    Authors:
    Denise Bellotti,* Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    BOOK OF ABSTRACTS XXVII congresso della SCI 2021, La chimica guida lo sviluppo sostenibile (rok: 2021, tom: XXVII Congresso della SCI, strony: 321), Wydawca: Società Chimica Italiana
    Data:
    konferencja 14-23 September 2021
    Status:
    Published
  12. Understanding the thermodynamics and coordination chemistry of metal-binding proteins: the common thread to elucidate metal acquisition processes at host/pathogen interface
    Authors:
    Denise Bellotti,* Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    BOOK OF ABSTRACTS XXVII congresso della SCI 2021, La chimica guida lo sviluppo sostenibile (rok: 2021, tom: XXVII Congresso della SCI, strony: 321), Wydawca: Società Chimica Italiana
    Data:
    konferencja 14-23 September 2021
    Status:
    Published
  13. Unravelling the antimicrobial properties of calcitermin and its peptide derivatives
    Authors:
    Denise Bellotti,* Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Proceedings of the Merck Young Chemists' Symposium XX Edition (rok: 2021, tom: MYCS 2021, strony: 115), Wydawca: G. Annunziato, M. Atzori, C. Bonfio, S. Cinti, B. Coppola, M. Da Pian, C. Imparato, V. Lazazzara, E. Lenci, A. Malara, D. Morselli, E. Paone, F. Ponte, S. Rebeccani, L. Rivoira, M. Schlich
    Data:
    konferencja 22-24 November 2021
    Status:
    Published
  14. Does the Ala-to-Ser substitution affect the metal-binding and biological properties of the antimicrobial peptide calcitermin?
    Authors:
    Silvia Leveraro, Denise Bellotti, Magdalena Rowińska-Žyrek, Maurizio Remelli, Remo Guerrini
    Conference:
    Proceedings of the Merck Young Chemist's Symposium 2023 (rok: 2023, tom: Merck Young Chemist's Symposium 2023, strony: 100), Wydawca: Italian Chemical Society
    Data:
    konferencja 13-15 November 2023
    Status:
    Published
    DOI:
    - - link to the publication
  15. Be positive! More than a state of mind behind the thermodynamic study of metal complexes with novel calcitermin peptide derivatives
    Authors:
    Denise Bellotti, Silvia Leveraro, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Atti del XXX Congresso della Divisione di Chimica Analitica della Società Chimica Italiana (rok: 2023, tom: XXX Congresso della Divisione di Chimica Analitica della Società Chimica Italiana, strony: 228), Wydawca: Italian Chemical Society
    Data:
    konferencja 17-21 September 2023
    Status:
    Published
    DOI:
    - - link to the publication
  16. A glance at the metal binding ability of fungal ZIP transporters: Zn(II) and Cu(II) interaction with the Zrt2 protein
    Authors:
    Denise Bellotti, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Acta of the International Symposia on Metal Complexes (rok: 2023, tom: nternational Symposia on Metal Complexes 2023, strony: 81), Wydawca: ISMEC GROUP
    Data:
    konferencja 11-14 June 2023
    Status:
    Published
    DOI:
    - - link to the publication
  17. Calcitermin and its peptide derivatives as promising antimicrobial agents with metal chelating ability
    Authors:
    Denise Bellotti,* Emilia Dzień, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Acta of the International Symposia on Thermodynamics of Metal Complexes XXXII Edition (rok: 2022, tom: ISMEC 2022, strony: 71-72), Wydawca: Demetrio Milea, Enrique García-España Monsonís, M. Paz Clares García
    Data:
    konferencja 5-8 June 2022
    Status:
    Published
    DOI:
    - - link to the publication
  18. The impact of metal coordination on calcitermin antimicrobial properties
    Authors:
    Denise Bellotti,* Silvia Leveraro, Emilia Dzień, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Atti del XXIX Congresso della Divisione di Chimica Analitica della Società Chimica Italiana (rok: 2022, tom: XXIX Conference of the Analytical Chemistry Division of the Italian Chemical Society, strony: 145), Wydawca: Società Chimica Italiana
    Data:
    konferencja 11-15 September 2022
    Status:
    Published
    DOI:
    - - link to the publication
  19. Calcitermin and its peptide derivatives as promising antimicrobial agents with metal chelating ability
    Authors:
    Denise Bellotti,* Emilia Dzień, Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Acta of the International Symposia on Thermodynamics of Metal Complexes XXXII Edition (rok: 2022, tom: ISMEC 2022, strony: 71-72), Wydawca: Demetrio Milea, Enrique García-España Monsonís, M. Paz Clares García
    Data:
    konferencja 5-8 June 2022
    Status:
    Published
    DOI:
    - - link to the publication
  20. Unravelling the antimicrobial properties of calcitermin and its peptide derivatives
    Authors:
    Denise Bellotti,* Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Proceedings of the Merck Young Chemists' Symposium XX Edition (rok: 2021, tom: MYCS 2021, strony: 115), Wydawca: G. Annunziato, M. Atzori, C. Bonfio, S. Cinti, B. Coppola, M. Da Pian, C. Imparato, V. Lazazzara, E. Lenci, A. Malara, D. Morselli, E. Paone, F. Ponte, S. Rebeccani, L. Rivoira, M. Schlich
    Data:
    konferencja 22-24 November 2021
    Status:
    Published
  21. Understanding the mechanism of ZinT-mediated metal acquisition: a thermodynamic study
    Authors:
    Denise Bellotti,* Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Acta of the International Symposia on Thermodynamics of Metal Complexes XXXI Edition (rok: 2021, tom: ISMEC 2021, strony: 176-177), Wydawca: Demetrio Milea, Sofia Gama
    Data:
    konferencja 16-18 June 2021
    Status:
    Published
  22. Understanding the mechanism of ZinT-mediated metal acquisition: a thermodynamic study
    Authors:
    Denise Bellotti,* Magdalena Rowińska-Żyrek, Maurizio Remelli
    Conference:
    Acta of the International Symposia on Thermodynamics of Metal Complexes XXXI Edition (rok: 2021, tom: ISMEC 2021, strony: 176-177), Wydawca: Demetrio Milea, Sofia Gama
    Data:
    konferencja 16-18 June 2021
    Status:
    Published
  1. Chapter Thirteen - Metal–protein solution interactions investigated using model systems: Thermodynamic and spectroscopic methods.
    Authors:
    Denise Bellotti, Silvia Leveraro, Maurizio Remelli
    Book:
    Methods in Enzymology (rok: 2023, tom: 687, strony: 279-341), Wydawca: Academic Press
    Status:
    Published
    DOI:
    10.1016/bs.mie.2023.05.004 - link to the publication

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